公开(公告)号：EP2852687A4

公开(公告)日：2016-10-05

申请号：EP13793337

申请日：2013-05-21

申请人： SCRIPPS RESEARCH INST

发明人： HEAD STEVEN ROBERT ,  ORDOUKHANIAN PHILLIP T ,  LOMON DANIEL R

IPC分类号： C12Q1/68 ,  C12P19/34 ,  G06F19/18

CPC分类号： B01J19/0046 ,  B01J2219/0059 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12Q1/6874 ,  C40B40/06 ,  C12Q2525/161 ,  C12Q2525/191 ,  C12Q2531/125 ,  C12Q2535/122 ,  C12Q2563/143

摘要： The present disclosure provides methods, compositions, and kits for methods that can improve techniques nucleic acid analysis, and can allow for more reliable and accurate targeted, multiplexed, high throughput sequencing. The methods, compositions, and kits can be used for sequencing target loci of nucleic acid. The methods, compositions, and kits disclosed herein can be used for assisted de novo targeted sequencing. The methods, compositions, and kits disclosed herein can also be used for library labeling for de novo sequencing and phasing.

公开(公告)号：EP2958889A4

公开(公告)日：2016-07-27

申请号：EP14754704

申请日：2014-02-25

申请人： SCRIPPS RESEARCH INST ,  UNIV TEXAS

发明人： BEUTLER BRUCE ,  BOGER DALE L

IPC分类号： C07C237/20 ,  A61K31/166 ,  A61K39/39 ,  A61K45/06 ,  A61P37/00

CPC分类号： A61K39/39 ,  A61K31/166 ,  A61K45/06 ,  C07C237/20 ,  C07C237/36 ,  C07C237/44 ,  A61K2300/00

公开(公告)号：EP2776458A4

公开(公告)日：2015-05-06

申请号：EP12848547

申请日：2012-11-07

申请人： SCRIPPS RESEARCH INST ,  MOSNIER LAURENT O ,  GRIFFIN JOHN H

发明人： MOSNIER LAURENT O ,  GRIFFIN JOHN H

IPC分类号： C07K14/47 ,  A61K38/00 ,  A61K38/17 ,  C07K14/705 ,  C12N5/10 ,  C12N15/12 ,  C12N15/85

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K38/177

摘要： The present invention provides novel PAR 1 derived cytoprotective oligopeptides or polypeptides which typically contain at least the first 4 N-terminal residues that are substantially identical to the corresponding N-terminal residues of Met1-Arg46 deleted human PAR 1 sequence. These cytoprotective oligopeptides or polypeptides are capable of activating PAR 1 and promoting PAR 1 cytoprotective signaling activities. The invention also provides engineered cells or transgenic non-human animals which harbor in their genome an altered PAR 1 gene that is resistant to cleavage at Arg41 and/or Arg46 residues. Additionally provided in the invention are methods of screening candidate compounds to identity additional cytoprotective compounds or cytoprotective proteases. The invention further provides therapeutic use or methods of employing a PAR 1 derived cytoprotective oligopeptide or polypeptide to treat conditions associated with tissue injuries or undesired apoptosis.

公开(公告)号：EP2694964A4

公开(公告)日：2014-10-29

申请号：EP12768275

申请日：2012-04-06

申请人： SCRIPPS RESEARCH INST

发明人： LASMEZAS CORINNE ,  WEISSMANN CHARLES

IPC分类号： G01N33/50 ,  G01N33/542 ,  G01N33/543

CPC分类号： G01N33/5023 ,  A61K31/14 ,  A61K31/35 ,  A61K31/351 ,  A61K31/436 ,  A61K31/454 ,  A61K31/4745 ,  G01N33/5041 ,  G01N33/5058 ,  G01N33/542 ,  G01N33/543 ,  G01N2500/04 ,  G01N2500/10

摘要： A method of screening for compounds that module expression of specific macromolecules, the “target”. The method is particularly useful in that it does not require separation of target-bound and excess ligand and therefore enables, but is not limited to, High Throughput Screening for compounds that increase or decrease the levels or amounts of a target present in a biological sample. The method can also be used for high-throughput diagnosis of a condition leading to an increase or decrease of a cellular macromolecule.

公开(公告)号：EP2616093A4

公开(公告)日：2014-02-26

申请号：EP11825668

申请日：2011-08-31

申请人： SCRIPPS RESEARCH INST

发明人： ROMESBERG FLOYD E ,  SMITH PETER A ,  ROBERTS TUCKER C

IPC分类号： A61K38/04 ,  A61K38/12

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  A61K38/14 ,  A61K45/06 ,  C07K9/001

摘要： Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.

公开(公告)号：EP2553086A4

公开(公告)日：2013-10-02

申请号：EP11763396

申请日：2011-03-30

申请人： SCRIPPS RESEARCH INST

发明人： ZHU SAIYONG ,  DING SHENG

IPC分类号： C12N5/071

CPC分类号： C12N5/0696 ,  C12N2501/065 ,  C12N2501/15 ,  C12N2501/41 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/727 ,  C12N2501/73 ,  C12N2506/03 ,  C12N2506/094 ,  C12N2506/28

摘要： The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3'-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.

摘要翻译： 本发明提供用于使用3'-磷酸肌醇依赖性激酶-1（PDK1）激活剂或促进糖酵解代谢的化合物从非多潜能哺乳动物细胞产生诱导多能干细胞的方法，组合物和试剂盒，以及 其他小分子。

公开(公告)号：EP2515914A4

公开(公告)日：2013-09-11

申请号：EP10840202

申请日：2010-12-23

申请人： SCRIPPS RESEARCH INST

发明人： BARBAS III CARLOS F ,  BAN HITOSHI ,  GAVRILYUK JULIA

IPC分类号： C07D403/14 ,  A61K31/675 ,  A61P35/00 ,  C07D249/12 ,  C07D417/10

CPC分类号： A61K47/48723 ,  A61K31/4196 ,  A61K31/439 ,  A61K31/47 ,  A61K47/6891 ,  C07D249/00 ,  C07D249/12 ,  C07D403/14 ,  C07D417/10

公开(公告)号：EP2291080A4

公开(公告)日：2013-09-11

申请号：EP09762826

申请日：2009-05-14

申请人： SCRIPPS RESEARCH INST

发明人： ROBERTS EDWARD ,  ROSEN HUGH ,  BROWN STEVEN ,  GUERRERO MIGUEL A ,  PENG XUEMEI ,  PODDUTOORI RAMULU

IPC分类号： C07D271/06 ,  A01N43/82 ,  A61K31/41 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

公开(公告)号：EP2446023A4

公开(公告)日：2013-08-28

申请号：EP10797604

申请日：2010-06-23

申请人： SCRIPPS RESEARCH INST

发明人： BALDWIN KRISTIN

IPC分类号： C12N5/074 ,  C12N5/10 ,  C12N15/12 ,  C12N15/86

CPC分类号： C12N5/0696 ,  A01K67/0271 ,  A01K2227/105 ,  C12N2501/065 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2510/00

摘要： The present invention provides methods and compositions for generating and using induced pluripotent stem cells.

公开(公告)号：EP2237797A4

公开(公告)日：2012-11-07

申请号：EP08870383

申请日：2008-12-24

申请人： SCRIPPS RESEARCH INST

发明人： BARBAS III CARLOS F

IPC分类号： A61K39/395

CPC分类号： C07K14/00 ,  C07K7/08 ,  C07K16/2848 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2319/035 ,  C07K2319/70 ,  C07K2319/74 ,  C12N9/0002 ,  G01N33/6845

摘要： Antibodies containing one or more modular recognition domains (MRDs) used to target the antibodies to specific sites are described. The use of the antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described.