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    METHOD FOR PRODUCING ALKYLDIMETHYLBENZYLAMMONIUM CHLORIDES
    96.
    发明公开
    METHOD FOR PRODUCING ALKYLDIMETHYLBENZYLAMMONIUM CHLORIDES 有权
    VERFAHREN ZUR HERSTELLUNG VON ALKYLDIMETHYLBENZYLAMMONIUMCHLORIDEN

    公开(公告)号：EP1505058A1

    公开(公告)日：2005-02-09

    申请号：EP03725930.6

    申请日：2003-04-21

    申请人： Nedd Marketing SA

    发明人： ZOTOV, Vyacheslav Ivanovich ,  MANKOVICH, Leonid

    IPC分类号： C07C211/63 ,  C07C209/12

    CPC分类号： C07C209/12 ,  C07C211/63

    摘要： The invention is meant for chemical industry and is applicable in production of household sanitizers and detergents. A mixture of commercial tertiary amines or a mixture of straight-run tertiary amines is rectified and fed into the reactor for synthesis of a quaternary ammonium compound by a reaction of said mixture with benzyl chloride under stirring and at an elevated temperature. The mass ratio of the tertiary amines-benzyl chloride mixture is between 1.57 and 1.81. It is preferred that the use is made of benzyl chloride refined by distillation at the atmospheric pressure and a temperature of 177-178° C. The derived quaternary ammonium compound consists essentially of dimethyl dodecyl benzyl ammonium chloride and tetradecyl dimethylbenzyl ammonium chloride, the mass ratio of which is controllable. The product can be obtained in the form of gel. Where water or an organic solvent is added to the reaction mixture, a dissolved product is obtained. The product is free from alkyl radicals with the number of carbon atoms over 14, is low-toxic, and its purity is at least 95 mass %. The proposed invention renders it possible to use inexpensive and procurable raw materials, to lower energy intensity and process time, 1 claim, 1 fig., 3 tabl., 5 emb.

    摘要翻译： 本发明适用于化学工业，适用于家用消毒剂和洗涤剂的生产。 将商品叔胺或直馏叔胺的混合物进行精馏，并在搅拌和升高的温度下，通过所述混合物与苄基氯的反应，将其加入到用于合成季铵化合物的反应器中。 叔胺 - 苄基氯混合物的质量比为1.57-1.81。 优选使用通过在大气压和177-178℃的温度下蒸馏精制的苄基氯。衍生的季铵化合物基本上由二甲基十二烷基苄基氯化铵和十四烷基二甲基苄基氯化铵组成，质量比 其中可控制。 该产品可以以凝胶的形式获得。 当向反应混合物中加入水或有机溶剂时，得到溶解产物。 该产物不含碳原子数超过14的烷基，为低毒，纯度至少为95质量％。 所提出的发明使得可以使用廉价和可原始的原材料来降低能量强度和处理时间，1权利要求1图3，第5页。

    USE OF HYALURONIC ACID AS AN IMMUNOSUPPRESSANT
    97.
    发明授权
    USE OF HYALURONIC ACID AS AN IMMUNOSUPPRESSANT 失效
    使用透明质酸ALS IMMUNSUPPESSOR的

    公开(公告)号：EP0852501B1

    公开(公告)日：2004-12-01

    申请号：EP96932347.6

    申请日：1996-09-27

    申请人： SANGSTAT MEDICAL CORPORATION

    发明人： LUSSOW, Alexander, R. ,  BUELOW, Roland

    IPC分类号： A61K31/715 ,  A61P37/08

    CPC分类号： A61K31/728

    摘要： A pharmaceutical formulation of hyaluronic acid is administered to a patient suffering from undesirable T cell activity. The hyaluronic acid inhibits T cell activity at doses that are well-tolerated by the recipient. Conditions suitable for treatment include graft vs. host disease, graft rejection and certain autoimmune diseases having a T cell component.

    Serum protein profiling for the diagnosis of epithelial cancers
    99.
    发明公开
    Serum protein profiling for the diagnosis of epithelial cancers 审中-公开
    血清蛋白分析fürdie诊断von Epithelkrebs

    公开(公告)号：EP1477803A1

    公开(公告)日：2004-11-17

    申请号：EP03090153.2

    申请日：2003-05-23

    申请人： Europroteome AG

    发明人： Ebert, Matthias ,  Wiemar, Jan ,  Meuer, Jörn

    IPC分类号： G01N33/48 ,  G01N33/50

    CPC分类号： G01N33/57488 ,  G01N30/8655 ,  G01N33/48 ,  G01N33/50 ,  G01N2030/8813 ,  G01N2030/8831

    摘要： The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion, subjects having an epithelial cancer or a metastasised epithelial cancer or subjects having an acute and chronic inflammation of the epithelium. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium.

    摘要翻译： 本发明提供生物分子和这些生物分子用于上皮癌的鉴别诊断或上皮的急性和慢性炎症的用途。 特别地，本发明提供了用于检测测试样品内的生物分子的方法以及包含对于健康受试者，具有癌前病变的受试者，具有上皮癌或转移性上皮癌的受试者或具有转移上皮癌的受试者的生物分子的质量分布的数据库 急性和慢性炎症的上皮细胞。 此外，本发明提供了使用气相离子光谱法表征所述生物分子的方法。 此外，本发明提供鉴定所述生物分子的方法，只要它们是蛋白质或多肽即可。 本发明还提供了用于上皮癌鉴别诊断或上皮的急性和慢性炎症的试剂盒。

    Poly-silicon layer of a thin film transistor and display device having the same
    100.
    发明公开
    Poly-silicon layer of a thin film transistor and display device having the same 有权
    Polysilizium-Schicht einesDünnfilmtransistorsand eine solche aufweisende Anzeigevorrichtung

    公开(公告)号：EP1317002A3

    公开(公告)日：2004-09-29

    申请号：EP02090384.5

    申请日：2002-11-20

    申请人： Samsung SDI Co. Ltd.

    发明人： Lee, Ki-Yong

    IPC分类号： H01L29/786

    CPC分类号： H01L29/78696 ,  H01L27/1285 ,  H01L27/1296 ,  H01L29/04 ,  H01L29/78675

    摘要： A poly-silicon layer of a thin film transistor (TFT) having an active channel region, wherein a probability P that a maximum number of a primary grain boundary exists on the active channel region is not 0.5, the probability obtained by the following equation:P = D - (N max - 1) · GsGs    , where D = L·cosθ +W·sinθ, L is a channel length of the active channel region, W is a width of the active channel region, Nmax is the maximum number of the primary boundary existing on the active channel region, Gs is a grain size, and θ is a tilt angle of the primary grain boundary and the display device having thereof.

    摘要翻译： 具有有源沟道区的薄膜晶体管（TFT）的多晶硅层，其中在有源沟道区上存在最大数量的一次晶界的概率P不是0.5，通过以下等式获得的概率： P = D - （N max-1）。 Gs DIVIDED Gs ，其中D = L.cos＆thetas; + W.sin＆thetas; L是有源沟道区的沟道长度，W是有源沟道区的宽度，Nmax是存在于有源沟道区上的主边界的最大数，Gs是晶粒尺寸， ＆θ驱动; 是一次晶界的倾斜角和具有该晶粒的显示装置。