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公开(公告)号：EP2870160B1
公开(公告)日：2016-09-28
申请号：EP13739324.5
申请日：2013-07-02
发明人： BJORNSON, Kyla , CANALES, Eda , COTTELL, Jeromy, J. , KARKI, Kapil, Kumar , KATANA, Ashley, Anne , KATO, Darryl , KOBAYASHI, Tetsuya , LINK, John, O. , MARTINEZ, Ruben , PHILLIPS, Barton, W. , PYUN, Hyung-jung , SANGI, Michael , SCHRIER, Adam, James , SIEGEL, Dustin , TAYLOR, James, G. , TRAN, Chinh, Viet , TREJO MARTIN, Teresa, Alejandra , VIVIAN, Randall, W. , YANG, Zheng-Yu , ZABLOCKI, Jeff , ZIPFEL, Sheila
IPC分类号： C07D491/18 , A61P31/14 , A61K31/4995 , C07K5/08 , A61K31/506 , A61K31/519 , A61K38/21 , A61K31/4985 , A61K31/4745
CPC分类号： A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
摘要： Compounds of Formula (IV), as well as pharmaceutically acceptable salts thereof, are disclosed: The compounds are useful in the treatment of Hepatitis C infections.
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92.发明公开PYRROLO [1,2,F][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS 审中-公开PYRROLO [1,2，F] [1,2,4] TRIZZINES可用于治疗呼吸道合胞病毒感染
公开(公告)号：EP3068405A1
公开(公告)日：2016-09-21
申请号：EP14806123.7
申请日：2014-11-06
IPC分类号： A61K31/706 , A61K31/16 , C07D487/04
CPC分类号： C07D487/04 , C07D405/04 , C07D405/14 , C07F9/6561 , C07H7/06
摘要： Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.
摘要翻译： 本文提供了用于治疗肺病毒病毒感染（包括呼吸道合胞体病毒感染）的制剂，方法和取代的四氢呋喃基 - 吡咯并[1,2-f] [1,2,4]三嗪-4-胺化合物 作为合成四氢呋喃基 - 吡咯并[1,2-f] [1,2,4]三嗪-4-胺化合物的方法和中间体。
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公开(公告)号：EP2487165B1
公开(公告)日：2016-09-14
申请号：EP12167594.6
申请日：2007-07-06
IPC分类号： C07D277/28 , C07D417/14 , A61K31/427 , A61P31/12
CPC分类号： A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
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公开(公告)号：EP2487162B1
公开(公告)日：2016-08-17
申请号：EP12167590.4
申请日：2008-02-22
发明人： Desai, Manoj, C. , Hong, Allen, Y. , Hui, Hon, C. , Liu, Hongtao , Vivian, Radall, W. , Xu, Lianhong
IPC分类号： C07D277/28 , C07D417/14 , A61K31/427 , A61P31/12
CPC分类号： C07D277/28 , C07D417/14
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公开(公告)号：EP2487166B1
公开(公告)日：2016-07-27
申请号：EP12167596.1
申请日：2008-02-22
发明人： Desai, Manoj, C. , Hong, Allen, Y. , Hui, Hon, C. , Liu, Hongtao , Vivian, Radall, W. , Xu, Lianhong
IPC分类号： C07D277/28 , C07D417/14 , A61K31/427 , A61P31/12
CPC分类号： C07D277/28 , C07D417/14
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公开(公告)号：EP3034499A1
公开(公告)日：2016-06-22
申请号：EP14004260.7
申请日：2014-12-17
发明人： Gege, Christian , Kinzel, Olaf , Kremoser, Claus
IPC分类号： C07D401/14 , C07D413/14 , A61K31/454 , A61P1/00 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00
CPC分类号： C07D471/08 , C07D261/08 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of formula (1) which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
摘要翻译： 本发明涉及结合NR1H4受体（FXR）并作为FXR激动剂的式（1）化合物。 本发明还涉及该化合物在制备用于通过所述化合物与所述核受体结合并通过所述化合物的合成方法治疗疾病和/或病症的药物中的用途。
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公开(公告)号：EP3027190A1
公开(公告)日：2016-06-08
申请号：EP14750949.1
申请日：2014-07-31
IPC分类号： A61K31/506 , A61P9/06
CPC分类号： C07D413/06 , A61K31/506 , A61K31/553
摘要： Described herein is a method of treating long QT syndrome by administration of an effective amount of a potent and selective late sodium ion channel blocker.
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公开(公告)号：EP2726466B1
公开(公告)日：2016-05-25
申请号：EP12735402.5
申请日：2012-06-29
发明人： CORKEY, Britton Kenneth , ELZEIN, Elfatih , JIANG, Robert H. , KALLA, Rao V. , KOLTUN, Dmitry , LI, Xiaofen , MARTINEZ, Ruben , PARKHILL, Eric Q. , PERRY, Thao , ZABLOCKI, Jeff , VENKATARAMANI, Chandrasekar , GRAUPE, Michael , GUERRERO, Juan
IPC分类号： C07D243/24 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/5513 , A61K31/553 , A61K31/554
CPC分类号： C07D413/06 , A61K31/5513 , A61K31/553 , C07B59/002 , C07B2200/05 , C07D243/14 , C07D243/24 , C07D267/08 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04
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99.发明公开
公开(公告)号：EP3006032A1
公开(公告)日：2016-04-13
申请号：EP15184628.4
申请日：2009-05-01
发明人： KOZIARA, Joanna M. , MENNING, Mark M. , OLIYAI, Reza , STRICKLEY, Robert G. , YU, Richard , KEARNEY, Brian P. , MATHIAS, Anita A.
CPC分类号： A61K9/2086 , A61K9/1611 , A61K9/2009 , A61K9/2054 , A61K9/2077 , A61K9/4866 , A61K31/00 , A61K31/5377 , A61K2300/00
摘要： The invention provides a composition or a tablet comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and a plurality of solid carrier particles, preferably silica particles, as well as a method for providing a mixture with said compound and particles. The compound of formula (I) inhibits the activity of cytochrome P-450.
摘要翻译： 本发明提供的组合物或片剂，其包含式（I）的化合物或其药学上可接受的盐和固体载体颗粒，优选二氧化硅颗粒的复数，以及用于提供与所述化合物和颗粒的混合物的方法。 式（I）的化合物抑制细胞色素P-450的活性。
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公开(公告)号：EP2987532A1
公开(公告)日：2016-02-24
申请号：EP15002478.4
申请日：2012-07-12
IPC分类号： A61P1/16 , A61P3/10 , A61P35/00 , A61K31/42 , C07D261/08 , C07D413/12 , C07D413/14
CPC分类号： A61K31/4439 , A61K31/42 , A61K31/422 , C07D261/08 , C07D413/12 , C07D413/14
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
摘要翻译： 本发明涉及结合NR1H4受体（FXR）并充当FXR激动剂的化合物。 本发明进一步涉及所述化合物在制备用于通过所述化合物结合所述核受体来治疗疾病和/或病症的药物中的用途以及用于合成所述化合物的方法。
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