公开(公告)号：EP1240901B1

公开(公告)日：2008-09-10

申请号：EP00987688.9

申请日：2000-12-21

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

发明人： NAKATOMI, Yasushi ,  TOMOKIYO, Kazuhiko ,  ARAKI, Tatsuya ,  TESHIMA, Kaori ,  WATANABE, Tomoko ,  NAKAGAKI, Tomohiro

IPC分类号： A61K38/37 ,  A61K38/36 ,  A61P7/04 ,  A61K38/48

CPC分类号： A61K38/4846

摘要： Medicinal compositions for preventing and treating hemorrhagic symptoms associating abnormal blood coagulation which contain as the main active ingredient a combination of activated blood coagulation factor VII (FVIIa) with blood coagulation factor X (FX). These compositions contain no component mainly causing side effects, are highly safe and efficacious, and make it possible to easily control hemostatis. Thus, these compositions are usable in controlling the hemostatis of, for example, patients suffering from blood coagulation failure due to, for example, abnormality (including defect) in blood coagulation factors, in particular, carrying a blood coagulation factor inhibitor (antibody).

公开(公告)号：EP1939283A1

公开(公告)日：2008-07-02

申请号：EP06810820.8

申请日：2006-09-29

申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

发明人： ONCHI, Tatsufumi, c/o JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTI C RESEARCH INSTITUTE, KIKUCHI RESEARCH CENTER, ,  NAKAHARA, Yo, c/o JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTI C RESEARCH INSTITUTE, KIKUCHI RESEARCH CENTER, ,  IMAMURA, Takayuki ,  NOUCHI, Toshinobu ,  NAKATAKE, Hiroshi

IPC分类号： C12N9/74 ,  C12N5/10 ,  C12N15/09

CPC分类号： C12N9/6429 ,  C12Y304/21005

摘要： The present invention provides for a process for preparing a recombinant human thrombin. A process for preparing a recombinant human thrombin which comprises: (1) obtaining a transfectant cell producing a human prothrombin by introducing an expression vector, wherein a gene fragment coding for a human prothrombin gene is incorporated, into an animal cell; (2) purifying a human prothrombin from the culture of the transfectant cell above by an anion exchanger; (3) converting the purified human prothrombin into a human thrombin by subjecting said human prothrombin to the action of ecarin; and (4) purifying the human thrombin from the solution after treatment with ecarin by an affinity method using benzamidine and a cation exchanger, and human thrombin obtained by said process, and a CHO cell that produces human prothrombin.

摘要翻译： 本发明提供了用于制备重组人凝血酶的方法。 一种制备重组人凝血酶的方法，包括：（1）获得转染细胞通过引入到表达载体中，用于worin人凝血酶原基因的基因片段编码产生人凝血酶原结合，导入动物细胞; （2）纯化从细胞转染子的培养人凝血酶原以上通过在阴离子交换剂; （3）将所述纯化的人凝血酶原成人凝血酶通过使所述人凝血酶原至蝰蛇毒的作用; 和（4）通过在亲和纯化的方法从与蝰蛇毒处理后的溶液中的人凝血酶使用苄脒和阳离子交换剂，以及由所述方法得到的人凝血酶，和CHO细胞没有产生人凝血酶原。

公开(公告)号：EP1852877A1

公开(公告)日：2007-11-07

申请号：EP06712398.4

申请日：2006-01-26

申请人： Sumitomo Electric Industries, Ltd. ,  International Superconductivity Technology Center, The Juridical Foundation

发明人： OHMATSU, Kazuya Osaka Works of Sumitomo El.Ind.Ltd ,  HAHAKURA, Shuji Osaka Works of Sumitomo El.Ind.Ltd

IPC分类号： H01B12/06 ,  H01B13/00 ,  H01F6/06

CPC分类号： H01L39/2448 ,  H01L39/143

摘要： A superconducting thin film material (1) is provided, including a first superconducting thin film (1a) having a surface subjected to smoothing and a second superconducting thin film (1b) formed on the surface of the first superconducting thin film (1a) subjected to the smoothing. Further, a superconducting wire (10) is provided, including a substrate (2), an intermediate layer (3) formed on the substrate (2), and a superconducting layer (4) formed on the intermediate layer (3), wherein the superconducting layer (4) is made of the superconducting thin film material (1) described above. Furthermore, a method of manufacturing the superconducting thin film material (1) and a method of manufacturing the superconducting wire (10) are provided.

摘要翻译： 的超导薄膜材料（1）被提供，其包括第一超导薄膜（1a）的具有经过平滑处理和第二超导薄膜的表面（图1b）所形成进行了第一超导薄膜（1a）的表面上 平滑。 此外，超导导线（10）被提供，包括基板（2）到中间层（3）形成在基板（2），和一个超导层（4）形成在中间层（3），worin的上 超导层（4）由上述的超导薄膜材料（1）的。 进一步，提供了制造超导薄膜材料（1）和制造所述超导导线（10）的方法的方法。

公开(公告)号：EP0781559B1

公开(公告)日：2007-02-07

申请号：EP96308676.4

申请日：1996-11-29

申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute ,  NOF CORPORATION

发明人： Miyahara, Tokuji ,  Takase, Kozo ,  Saito, Koichi ,  Kishimoto, Yoko ,  Tokuyama, Satoru

IPC分类号： A61K39/39 ,  A61K9/113

CPC分类号： A61K39/39 ,  A61K2039/55566 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/943

公开(公告)号：EP1683207A1

公开(公告)日：2006-07-26

申请号：EP05768737.8

申请日：2005-07-29

申请人： KABUSHIKI KAISHA TOSHIBA ,  International Superconductivity Technology Center, The Juridical Foundation

发明人： ARAKI, Takeshi Intellectual Property Division ,  NAKAO, Koichi Superconductivity Research Lab. ,  HIRABAYASHI, Izumi Superconductivity Research Lab.

IPC分类号： H01L39/24 ,  C23C18/12

CPC分类号： C23C18/1216 ,  C23C18/1254 ,  C23C18/1279 ,  C23C18/1283 ,  H01L39/2425 ,  Y10T428/265

摘要： The present invention relates to a method of preparing an oxide superconducting film, the method includes reacting a metal acetate containing metal M selected from the group consisting of lanthanum, neodymium and samarium with fluorocarboxylic acid having not less than three carbon atoms, reacting barium acetate with fluorocarboxylic acid having two carbon atoms, reacting copper acetate with fluorocarboxylic acid having not less than two carbon atoms, respectively, followed by refining reaction products, dissolving the reaction products in methanol such that a molar ratio of the metal M, barium and copper is 1 : 2 : 3 to prepare a coating solution, and coating a substrate with the coating solution to form a gel film, followed by calcining and firing the gel film to prepare an oxide superconducting film.

公开(公告)号：EP1674442A1

公开(公告)日：2006-06-28

申请号：EP04792145.7

申请日：2004-10-07

申请人： Juridical Foundation Osaka Industrial Promotion Organization

发明人： MANSEKI, Kazuhiro ,  HASEGAWA, Yasuchika ,  YANAGIDA, Shozo

IPC分类号： C07C49/92 ,  C07C69/88 ,  C08K5/00 ,  C08L101/00 ,  C07F5/00 ,  C09K11/06

CPC分类号： C07F5/003 ,  C07C69/88 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/182

摘要： The present invention provides a fluorescent substance excellent in thermal resistance, which can be uniformly dispersed into plastic materials, and has a high fluorescence intensity even after experienced heat history in plastic forming processes. More specifically, the present invention provides a fluorescent substance containing a rare earth complex having benzophenone or benzoyl substituted with an alkyl group, a cycloalkyl group, an acyl group or an alkoxy group having a carbon number of 1 to 20 as a skeletal structure, in which a plurality of rare earth ions are coordinated with one or more types of molecules having a photosensitizing function.

摘要翻译： 本发明提供一种耐热性优异的荧光物质，其可以均匀地分散在塑料材料中，并且即使在塑性成形过程中经历了热历史后也具有高荧光强度。 更具体地说，本发明提供一种荧光物质，其含有以烷基，环烷基，酰基或碳数为1至20的烷氧基取代的二苯甲酮或苯甲酰基作为骨架结构的稀土配合物， 其中多种稀土离子与一种或多种具有光敏功能的分子配位。

公开(公告)号：EP1661989A1

公开(公告)日：2006-05-31

申请号：EP04770968.8

申请日：2004-07-28

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

发明人： MATSUYAMA, Reiko, Chemo-Sero-Therapeutic Res.Inst. ,  MAEDA, Hiroaki, Chemo-Sero-Therapeutic Res.Inst.

IPC分类号： C12N15/00 ,  C12N5/00

CPC分类号： C07K14/75

摘要： When genes encoding three kinds of proteins constituting fibrinogen, an α chain (or variant of α chain), a β chain and a γ chain (or variant of γ chain) are incorporated into an animal cell, a constitutional ratio of respective genes is such that a γ chain (and/or variant of γ chain) gene is an equal amount to a 1000-fold amount relative to an α chain (and/or variant of α chain) gene and a β chain gene and, further, by using a baculovirus P35 gene, a recombinant fibrinogen highly producing cell is prepared.

摘要翻译： 当编码3种构成纤维蛋白原至±链（或±链的变体），一个²链和³链（或³链的变体）的蛋白质的基因被引入到动物细胞，检查respectivement基因的构成比 做了³链（和/或³链的变体）基因是等量〜1000倍相对于量在±链（和/或±链变体）基因和²链基因，并且进一步，通过使用 杆状病毒P35基因，高度生产细胞的重组纤维蛋白原制备。

公开(公告)号：EP1661911A1

公开(公告)日：2006-05-31

申请号：EP04772501.5

申请日：2004-08-31

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute ,  Kowa Company. Ltd.

发明人： NAKASHIMA, Toshihiro c/o JURIDICAL FOUNDATION THE ,  SASAKI, Takumi c/o JURIDICAL FOUNDATION THE ,  NISHIHARA, Tsukasa c/o JURIDICAL FOUNDATION THE ,  TAKEMOTO, Sumiyo c/o JURIDICAL FOUNDATION THE ,  SAKATA, Atsuko ,  OHKUCHI, Masao ,  KOSHI, Tomoyuki ,  EDANO, Toshiyuki

IPC分类号： C07K14/31 ,  A61K39/085 ,  A61P37/08 ,  C12N15/31

CPC分类号： C07K14/31 ,  A61K39/00

摘要： A modified Staphylococcal enterotoxin B (SEB) having resistance to a protease and a reduced toxicity and a vaccine comprising said modified SEB are provided. A modified SEB which has an amino acid sequence as set forth in SEQ ID NO: 1 wherein each of the lysine at 97-position and the lysine at 98-position are substituted with any other amino acid, or a derivative thereof and a vaccine comprising said modified SEB or a derivative thereof.

摘要翻译： 提供了具有对蛋白酶的抗性和毒性降低的改良的葡萄球菌肠毒素B（SEB）和包含所述修饰的SEB的疫苗。 具有如SEQ ID NO：1所示的氨基酸序列的修饰SEB，其中97位的赖氨酸和98位的赖氨酸被任何其它氨基酸或其衍生物取代，并且包含 所述经修饰的SEB或其衍生物。

公开(公告)号：EP1609860A1

公开(公告)日：2005-12-28

申请号：EP04723360.6

申请日：2004-03-25

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute ,  Kowa Co., Ltd.

发明人： NAKASHIMA, Toshihiro, Juridical Foundation ,  SASAKI, Takumi, Juridical Foundation ,  KIMACHI, Kazuhiko, Juridical Foundation ,  KUWATA, Shigeki, Juridical Foundation ,  NISHIHARA, Tsukasa, Juridical Foundation ,  SAKATA, Atsuko ,  OHKUCHI, Masao ,  KOSHI, Tomoyuki ,  EDANO, Toshiyuki

IPC分类号： C12N15/09 ,  C07K14/47 ,  A61K38/17 ,  A61P37/08

CPC分类号： A61K38/164 ,  C07K14/31 ,  C07K16/1271

摘要： A novel prophylactic/remedy for immunopathy is provided which is not neutralized by a neutralizing antibody to Staphylococcal enterotoxin B (SEB), known as one of superantigens, and may effectively act as a superantigen. A modified SEB having a reduced reactivity with a neutralizing antibody to SEB (anti-SEB antibody) and a prophylactic/remedy for immunopathy comprising as an active ingredient said modified SEB. The modified SEB of the present invention may be prepared with the evolutionary molecular engineering technique by introducing amino acid substitution in the amino acid sequence of SEB, especially at an epitope recognition site of the anti-SEB antibody in the amino acid sequence of SEB.

摘要翻译： 用于免疫疾病的新型的预防/治疗剂是所有未通过中和抗体来葡萄球菌肠毒素B（SEB），被称为超抗原的一种中提供，并且可以有效地充当超抗原。 具有的中和抗体，以SEB（抗SEB抗体）和用于免疫疾病包含作为活性成分的预防/治疗剂，降低的反应性的改性SEB所述改性SEB。 本发明的改性SEB可与由在SEB的氨基酸序列中引入氨基酸取代的进化分子工程技术来制备，爱特别是在对SEB的氨基酸序列中的抗SEB抗体的表位识别位点。

公开(公告)号：EP1602720A1

公开(公告)日：2005-12-07

申请号：EP04713206.3

申请日：2004-02-20

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

发明人： KOYANAGI, Satoshi, Chemo-sero-therap. res.inst. ,  SUGAWARA, Keishin, Chemo-sero-therap. res.inst. ,  MIYATSU, Yoshinobu, Chemo-sero-therap. res. inst. ,  MURAKAMI, Toshio, Chemo-sero-therap. research inst ,  MAEDA, Toshihiro, Chemo-sero-therapeut. res.inst. ,  MIZOKAMI, Hiroshi, Chemo-sero-therap. res.inst.

IPC分类号： C12N15/09 ,  C12P21/02

CPC分类号： C07K14/43531 ,  C12N15/70 ,  C12P21/02

摘要： A heterologous protein free from an inducer and a method for producing said protein are provided. A method for producing a heterologous protein which comprises the step of optionally culturing at low temperature recombinant E. coli cells expressing a heterologous protein under control of a promoter capable of inducing expression through temperature shift and then culturing at high temperature said recombinant E. coli cells in the absence of an inducer to thereby allow for expression of said heterologous protein, or the step of culturing at high temperature said recombinant E. coli cells to thereby simultaneously allow for both cell proliferation and expression of said heterologous protein, and the heterologous protein obtained by said method that is free from an inducer. Such heterologous protein may include a major mite allergen, a secretary macrophage toxin from Actinobacillus pleuropneumoniae and a surface protective antigen (SpaA) of Erysipelothrix rhusiopathiae.

摘要翻译： 提供了不含诱导物的异源蛋白质和生产所述蛋白质的方法。 一种产生异源蛋白质的方法，其包括在低温下表达异源蛋白质的重组大肠杆菌细胞在能够通过温度转移诱导表达，然后在高温下培养的启动子的控制下培养的步骤，所述重组大肠杆菌细胞 在不存在诱导物从而允许所述异源蛋白质的表达的情况下，或在高温下培养所述重组大肠杆菌细胞从而同时允许所述异源蛋白质的细胞增殖和表达的步骤，并且获得的异源蛋白质 通过所述方法不含诱导剂。 这种异源蛋白质可以包括主要的螨变应原，来自胸膜肺炎放线杆菌的秘密巨噬细胞毒素和Erysipelothrix rhusiopathiae的表面保护性抗原（SpaA）。