公开(公告)号：EP1904631A2

公开(公告)日：2008-04-02

申请号：EP06785367.1

申请日：2006-06-23

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： FAABERG, Kay, S. ,  HAN, Jun ,  LIU, Gongping ,  WANG, Yue

IPC分类号： C12N15/09

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N2770/10021 ,  C12N2770/10022 ,  C12N2770/10043

摘要： The present invention provides isolated infectious polynucleotides, such as infectious clones, having a nucleotide sequence with identity to PRRS viruses such as VR-2332, Lelystad, or others, and optionally further including a deletion in a region of ORFl that encodes the nsp2 polypeptide.

公开(公告)号：EP1877540A1

公开(公告)日：2008-01-16

申请号：EP05856697.7

申请日：2005-05-05

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： BLAZAR, Bruce ,  TOLAR, Jakub ,  VERFAILLIE, Catherine M.

IPC分类号： C12N5/06 ,  A61K39/00

CPC分类号： A61K35/28 ,  A61K2035/122 ,  C07K16/28 ,  C12N5/0607

摘要： The present invention relates to the use of a means for inhibiting NK cell function to increase persistence and/or engraftment of MHC-I negative cells, such as MAPCs.

公开(公告)号：EP1871385A1

公开(公告)日：2008-01-02

申请号：EP06720482.6

申请日：2006-02-08

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Department of Veterans Affairs ,  EMORY UNIVERSITY ,  Universidade de Lisboa

发明人： STEER, Clifford, J. ,  LOW, Walter, C. ,  OLSEN, Timothy, W. ,  BOATRIGHT, Jeffrey H. ,  NICKERSON, John M. ,  PARDUE, Machelle T. ,  RODRIGUES, Cecilia M. P.

IPC分类号： A61K31/575 ,  A61P25/28

CPC分类号： A61K31/575

摘要： The present invention provides methods for treating visual disorders. Exemplary visual disorders include macular degeneration, retinitis pigmentosa, glaucoma, and/or retinal degeneration.

公开(公告)号：EP1869062A1

公开(公告)日：2007-12-26

申请号：EP06740130.7

申请日：2006-03-29

申请人： The Regents of the University of Minnesota

发明人： KRASUTSKY, Pavel, A. ,  PUSHECHNIKOV, Alexei ,  SERGEEVA, Tatiana

IPC分类号： C07J63/00

CPC分类号： C07J63/008

摘要： The present invention provides a process of preparing betulin-28-aldehyde from betulin. The process includes contacting betulin with a compound of formula (I), e.g., TEMPO (2,2,6,6-tetramethylpiperidine 1-oxyl) for a period of time effective to provide betulin-28-aldehyde. The present invention also provides a process of preparing betulinic acid. The process includes contacting betulin with a composition that includes: sodium hypochlorite (NaOCl); sodium chlorite (NaClO2), potassium chlorite (KClO2), or a combination thereof; and a compound of formula (I), e.g., TEMPO (2,2,6,6-tetramethylpiperidine 1-oxyl); for a period of time effective to provide betulinic acid.

公开(公告)号：EP1137785B8

公开(公告)日：2007-11-21

申请号：EP99966013.7

申请日：1999-12-03

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： CLEARY, Paul, Patrick ,  STAFSLIEN, Deborah, K.

IPC分类号： C12N15/57 ,  C12N9/52 ,  A61K39/09

CPC分类号： C12N9/6424 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/522 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/6087 ,  C12N9/52 ,  C12Y304/21043 ,  Y10S424/823 ,  Y10S424/825 ,  Y10S424/828 ,  Y10S424/829 ,  Y10S424/831 ,  Y10S530/825

公开(公告)号：EP1828427A1

公开(公告)日：2007-09-05

申请号：EP05816231.4

申请日：2005-11-30

申请人： The Regents of the University of Minnesota ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： GLADFELTER, Wayne L. ,  SENOCQ, François ,  CAUSSAT, Brigitte ,  VAHLAS, Constantin

IPC分类号： C23C10/08 ,  B01J2/00 ,  B01B1/00

CPC分类号： C23C16/4481 ,  B01B1/005 ,  B01D3/346 ,  C23C10/06

摘要： The present invention relates to a device (30) for providing vapors of at least one solid precursor intended to supply a physico-chemical processing device (12), comprising an enclosure (32) capable of containing particles of the solid precursor and comprising an inlet (34) and an outlet (36) , the outlet being intended to be connected to the physico-chemical processing device; and means (42, 43, 44) for circulating a gas between the inlet and the outlet to put the particles of the solid precursor in the form of a fluidized bed, and to convey to the outlet vapors of the solid precursor.

公开(公告)号：EP1827460A1

公开(公告)日：2007-09-05

申请号：EP05853381.1

申请日：2005-12-08

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： WAGNER, Carston, R.

IPC分类号： A61K31/70 ,  A61K38/02 ,  C07H1/00

CPC分类号： C07H19/23 ,  C07F9/6561 ,  C07F9/65616 ,  C07H1/00 ,  C07H19/052 ,  C07H19/10 ,  C07H19/16 ,  C07H19/167 ,  C07H19/19 ,  C07H19/20 ,  C07H19/207 ,  C07K2/00 ,  C07K4/00

摘要： The invention provides a compound of formula (I), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.

公开(公告)号：EP1799362A2

公开(公告)日：2007-06-27

申请号：EP05784300.5

申请日：2005-08-11

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： HENDRICKSON, David, W. ,  KIESEL, Richard, F. ,  BLEIFUSS, Rodney, L.

IPC分类号： B07C5/00

CPC分类号： B07B1/10 ,  B07B13/05 ,  B07B15/00

摘要： Apparatus, methods and systems are used to separate fines from objects of a feed mixture being processed (e.g., iron bearing pellets, chips and dust). For example, at least a portion of an endless belt defining a channel is movable up an incline relative to horizontal (e.g., an incline that is at an angle relative to horizontal that is greater than an angle of repose associated with the objects, but less than an angle of repose associated with the fines being removed). Further, obstruction elements may be used on the endless belt to impede the flow of the fines down the incline.

公开(公告)号：EP1753439A2

公开(公告)日：2007-02-21

申请号：EP05772716.6

申请日：2005-05-17

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Low, Walter C. ,  Xiao, Jing ,  Nan, Zhenhong

发明人： LOW, Walter ,  XIAO, Jing ,  NAN, Zhenhong

IPC分类号： A61K35/14 ,  A61P25/00

CPC分类号： A61K35/51 ,  C12N5/0647 ,  C12N2501/11 ,  C12N2501/115

摘要： The invention relates generally to methods for isolation and culture of umbilical cord blood stem cells, cells isolated by the methods, and therapeutic uses for those cells.

公开(公告)号：EP1732949A2

公开(公告)日：2006-12-20

申请号：EP05777592.6

申请日：2005-04-07

申请人： Rinat Neuroscience Corp. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： SHELTON, David, L. ,  MANTYH, Patrick, William

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76

摘要： The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.