公开(公告)号：EP2493452B1

公开(公告)日：2013-07-17

申请号：EP10766066.4

申请日：2010-10-21

Applicant: BASF SE

Inventor： KOLTER, Karl ,  ANGEL, Maximilian ,  BREINER, Thomas

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/50 ,  C08F2/12 ,  C08F220/34 ,  C09D5/02 ,  C09D133/14 ,  C09J133/14 ,  C08F2/22 ,  C08F220/14

CPC classification number: A61K47/32 ,  A61K9/10 ,  A61K9/2846 ,  C08F220/14 ,  C08F220/34 ,  C08K3/014 ,  C08K3/24 ,  C08K3/26 ,  C08K5/005 ,  C08K5/13 ,  C08K5/17 ,  C08K5/175 ,  C08K2003/262

Abstract: A coating material, containing a mixture of i) a polymer obtained by radical polymerization from a) N,N-diethylaminoethyl methacrylate, and b) at least one radically polymerizable compound, selected from esters of α,&bgr;-ethylenically unsaturated mono- and dicarboxylic acids with C1-C18 alkanols, as component A, ii) one or more antioxidants as component B, iii) one or more plasticizers as component C, and iv) other excipients as components D, wherein the total amount of the mixture of components A-D is 100 wt. %.

公开(公告)号：EP2504033A1

公开(公告)日：2012-10-03

申请号：EP10776706.3

申请日：2010-11-12

Applicant: BASF SE

Inventor： DJURIC, Dejan ,  KOLTER, Karl ,  HERTING, Michael Gerrit

IPC: A61K47/10 ,  A61K47/34 ,  A61K31/00 ,  A61K9/00

CPC classification number: A61K9/006 ,  A61K47/10 ,  A61K47/34

Abstract: Film-like pharmaceutical dosage forms, comprising, as film formers, amphiphilic copolymers and one or more active substances.

公开(公告)号：EP2229151B1

公开(公告)日：2012-08-08

申请号：EP08858493.3

申请日：2008-12-10

Applicant: BASF SE

Inventor： KOLTER, Karl ,  ANGEL, Maximilian ,  MEYER-BÖHM, Kathrin

IPC: A61K9/20 ,  A61K9/14 ,  A61K47/24

CPC classification number: A61K9/2027 ,  A61K9/146 ,  A61K47/20 ,  A61K47/24

Abstract: The invention relates to polymeric, water-soluble salts of poorly water-soluble medicaments, comprising a polymer which is water-soluble at pH 2-13 of anionic character with a poorly-soluble medicament of cationic character.

公开(公告)号：EP2429492A2

公开(公告)日：2012-03-21

申请号：EP10718209.9

申请日：2010-05-11

Applicant: BASF SE

Inventor： KOLTER, Karl ,  DJURIC, Dejan ,  FISCHER, Stefan

IPC: A61K9/14 ,  A61K47/10 ,  A61K47/34 ,  A61K31/00

CPC classification number: A61K47/38 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/192 ,  A61K31/216 ,  A61K31/4164 ,  A61K31/4425 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/635 ,  A61K47/32 ,  A61K47/34 ,  C08F283/06

Abstract: The invention relates to dosage forms which contain preparations of poorly water-soluble substances in a polymer matrix of polyether copolymers, said polyether copolymers being obtained by the radically initiated polymerization of a mixture from 30 to 80% by weight of N-vinyl lactam, 10 to 50% by weight of vinyl acetate and 10 to 50% by weight of a polyether, and at least one poorly water-soluble polymer, the poorly water-soluble substance being present in the polymer matrix as an amorphous substance.

Abstract translation: 包括在聚醚共聚物的聚合物基质的略溶于水的活性物质的制剂的剂型，所述聚醚共聚物而获得通过的从30％至80％的混合物的自由基聚合（重量）N-乙烯基内酰胺的，为10〜50％的 重量的乙酸乙烯酯和10至50重量％的聚醚，和至少一种微溶于水的聚合物，其中的微水溶性的活性物质是存在于聚合物基体的无定形形式的。

公开(公告)号：EP2344138A2

公开(公告)日：2011-07-20

申请号：EP09783239.8

申请日：2009-09-21

Applicant: BASF SE

Inventor： MEYER-BÖHM, Kathrin ,  DOBRAWA, Rainer ,  MASCHKE, Angelika ,  KOLTER, Karl

IPC: A61K9/16 ,  A61K9/20

CPC classification number: A61K47/34 ,  A61K9/1641 ,  A61K9/2031 ,  A61K9/2095

Abstract: Use of water-soluble or water-dispersible copolymers obtained through radically-initiated polymerization of a mixture of i) 30 to 80 wt.-% of N-vinyl lactam, ii) 10 to 50 wt.-% of vinyl acetate and iii) 10 to 50 wt.-% of a polyether as a binder for the manufacture of dosing forms comprising solid active ingredients, said copolymers being conditioned in that the total of i), ii) and iii) is equal to 100 wt.-%.

公开(公告)号：EP1763340B1

公开(公告)日：2011-03-02

申请号：EP05770157.5

申请日：2005-06-22

Applicant: BASF SE

Inventor： KOLTER, Karl ,  ANGEL, Maximilian ,  HABICH, Andreas

IPC: A61K9/28

CPC classification number: A61K9/2853 ,  A61K9/284

Abstract: The invention relates to a rapidly dispersible, fine-grained, separation-resistant film coating agent for coating pharmaceutical dosage forms, consisting of a) 40 - 90 wt % of a polyvinyl alcohol-polyether graft copolymer (component A), b) 1 - 20 wt. % of a polyvinyl pyrrolidone or a vinyl pyrrolidone-vinyl acetate copolymer with a K-value of between 10 and 100 (component B), c) 10 - 60 wt. % of an organic or inorganic pigment with an average particle size that is less than 8 μm (component C), d) 0.5 - 15 wt. % of a surfactant with an HLB value that is greater than 10 (component D) and e) 0 - 30 wt % of additional conventional coating constituents (component E). In said agent, the particles of component C are embedded in a coherent polymer matrix and the quantity of components A to E totals 100 wt. %.

Abstract translation: 快速分散的，细颗粒膜的涂料组合物，其全部是粉末形式的，并且不容易产生偏析用于涂覆药物剂型，按重量计聚乙烯醇 - 聚醚接枝共聚物组成的）40-90％（A成分） b）1-20％（重量）的聚乙烯吡咯烷酮或具有从10至100（b成分）C）10-60％的K值乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物的重量平均具有有机或无机颜料 小于8的妈妈（组分C）D）（重量）具有（大于10（D成分的HLB）和e）0-30重量％的常用包衣成分进一步分量e的表面活性剂的0.5-15％的粒径 ），其中组分C的颗粒被嵌入在一个相干聚合物基质，其中组分A至E中的总量为100％（重量）。

公开(公告)号：EP1553830B1

公开(公告)日：2011-02-23

申请号：EP03748119.9

申请日：2003-10-06

Applicant: BASF SE

Inventor： DIETSCHE, Frank ,  BOUILLO, Nathalie ,  KOLTER, Karl ,  HAMERS, Christoph

IPC: A01N41/04 ,  C02F1/50 ,  A01P1/00

CPC classification number: A61L2/18 ,  A01N41/04 ,  C02F1/50 ,  Y10S422/905

Abstract: Disclosed is a method for destroying microorganisms in aqueous technical systems or products for water-based technical applications by adding 0.001 to 5 percent by weight of a water-soluble or water-dispersible polymer containing 30 to 100 molar percent of styrene sulfonic acid, 0 to 40 molar percent of an N-vinyllactam and/or N-vinylamine, and 0 to 30 molar percent of additional radically polymerizable monomers as a biocidal additive. Also disclosed is a method for protecting objects by applying an antimicrobially active aqueous composition comprising such an additive.

公开(公告)号：EP1851269B1

公开(公告)日：2010-06-09

申请号：EP06708084.6

申请日：2006-02-08

Applicant: BASF SE

Inventor： KOLTER, Karl ,  GARCIA CASTRO, Ivette ,  PINNEKER, Olga ,  WIDMAIER, Ralf ,  STRUBE, Karl-Hermann ,  FUSSNEGGER, Bernhard ,  KROLL, Manfred ,  HÖFER, Frank ,  ASCHERL, Hermann ,  SCHMIDT, Peter

IPC: C08K3/30 ,  C08K5/04 ,  C08L39/06

CPC classification number: C08K5/005 ,  C08F6/06 ,  C08K3/30 ,  C08K5/1535 ,  C08K2003/309 ,  C08K2201/014 ,  C08L39/06

Abstract: Disclosed is a method for stabilizing polyvinylpyrrolidones, which is characterized in that the polyvinylpyrrolidones are treated with sulfur dioxide, sulfurous acid, or alkali metal sulfites and then with radical absorber, and the treated solutions are transformed into the powdered polyvinylpyrrolidones by means of drying.

公开(公告)号：EP2176301A1

公开(公告)日：2010-04-21

申请号：EP08786773.5

申请日：2008-08-01

Applicant: BASF SE

Inventor： ANGEL, Maximilian ,  KOLTER, Karl ,  VOSS, Hartwig

IPC: C08F2/12 ,  C08F220/34 ,  C09D5/02 ,  C09D133/14 ,  C09J133/14 ,  A61K47/00 ,  A23L1/00

CPC classification number: C08K3/20 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/1635 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/5026 ,  A61K47/32 ,  C08F2/22 ,  C08F220/14 ,  C08F220/34 ,  C09D133/14 ,  C09J133/14

Abstract: The present invention relates to a process for the preparation of an aqueous polymer dispersion by free-radical emulsion polymerization of a monomer mixture which comprises N,N-diethylaminoethyl methacrylate, to the polymer dispersion obtainable by this process and to its use.

公开(公告)号：EP1696738B1

公开(公告)日：2008-05-14

申请号：EP04803656.0

申请日：2004-12-09

Applicant: BASF SE

Inventor： KRÄMER, Klaus ,  KOLTER, Karl ,  WOOLF, Herbert, Dennis

IPC: A23L1/00

CPC classification number: A21D6/00 ,  A21D13/20 ,  A21D15/08 ,  A23B4/10 ,  A23B5/06 ,  A23B7/16 ,  A23G3/343 ,  A23G2200/00 ,  A23L3/3454 ,  A23L19/03 ,  A23P20/00

Abstract: The invention relates to a method for treating the surface of food products by applying a polymer film, wherein a polyvinyl alcohol-polyether graft copolymer in the form of an aqueous dispersion is applied on the food product as the film-forming polymer.