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    Use of creatine or creatine analogs for the tratment of diseases of the nervous system
    98.
    发明公开
    Use of creatine or creatine analogs for the tratment of diseases of the nervous system 失效
    使用肌酸或肌酸类似物的神经系统疾病的治疗

    公开(公告)号：EP1719510A1

    公开(公告)日：2006-11-08

    申请号：EP06011215.8

    申请日：1995-11-07

    申请人： Avicena Group, Inc. ,  THE GENERAL HOSPITAL CORPORATION

    发明人： Kaddurah-Daouk, Rima ,  Daouk, Ghaleb ,  Beal, M., Flint

    IPC分类号： A61K31/195 ,  A61K31/66 ,  A61K31/675

    CPC分类号： A61K31/675 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/415 ,  A61K31/505 ,  A61K31/664

    摘要： The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer disease, Parkinson's disease, stroke, Huntington's disease, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The Creatine compounds which can be used in the present method include: (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.

    摘要翻译： 本发明涉及使用肌酸化合物，包括肌酸，磷酸肌酸或肌氨酸的类似物，：如环肌酸，用于治疗神经系统的疾病。肌酸化合物可被用作治疗有效试剂对抗多种神经系统疾病 ：例如糖尿病和毒性神经病，外周神经系统疾病，阿尔茨海默氏病，帕金森氏病，中风，亨廷顿病，运动神经元病，创伤性神经损伤，多发性硬化，脱髓鞘和髓鞘形成障碍病症，和线粒体疾病。 可以在本方法中使用的肌酸化合物包括：（1）肌酸，磷酸肌酸和合成的化合物能够作为底物类似物或用于肌酸激酶底物起作用的类似物; （2）肌酸激酶抑制剂双底物包含三磷酸腺苷（ATP）和肌酸的共价连接的结构类似物; （3）肌酸的类似物可以充当肌酸激酶作为可逆的或不可逆的酶抑制剂，和（4）N-phosphorocreatine类似物轴承，其模仿所述N磷酰基不可转移部分。

    USE OF CREATINE OR CREATINE ANALOGS FOR THE TREATMENT OF HUNTIGTON'S DISEASE, PARKINSON'S DISEASE AND AMYOTROPHIC LATERAL SCLEROSIS
    99.
    发明授权
    USE OF CREATINE OR CREATINE ANALOGS FOR THE TREATMENT OF HUNTIGTON'S DISEASE, PARKINSON'S DISEASE AND AMYOTROPHIC LATERAL SCLEROSIS 失效
    肌酸OR KREATINANOLOGEN的亨廷顿舞蹈病，帕金森氏病和肌萎缩性侧索硬化的治疗中

    公开(公告)号：EP0804183B1

    公开(公告)日：2006-07-05

    申请号：EP95939858.7

    申请日：1995-11-07

    申请人： Avicena Group, Inc. ,  THE GENERAL HOSPITAL CORPORATION

    发明人： KADDURAH-DAOUK, Rima ,  DAOUK, Ghaleb ,  BEAL, M., Flint

    IPC分类号： A61K31/195 ,  A61K31/66 ,  A61K31/675

    CPC分类号： A61K31/675 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/415 ,  A61K31/505 ,  A61K31/664

    摘要： The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer disease, Parkinson's disease, stroke, Huntington's disease, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The Creatine compounds which can be used in the present method include: (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase; and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.