-
1.发明公开MALONAMIDE AND MALONAMIC ESTER DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY, THEIR PREPARATION AND THEIR USE 有权具有抗血栓作用，生产和使用MALONAMID-和丙二酯衍生物
公开(公告)号：EP1339673A1
公开(公告)日：2003-09-03
申请号：EP01974267.5
申请日：2001-09-20
IPC分类号： C07C257/18 , C07C257/20 , A61K31/155 , A61P7/02
CPC分类号： A61K31/27 , A61K31/167 , A61K31/225 , C07C257/18 , C07C257/20
摘要： The present invention relates to compounds of formula (I), in which R1, R1, A and B have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
-
2.发明公开Neue Benzamidoxim-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung und deren Verwendung als Fungizide 审中-公开新的苯甲酰胺衍生物，中间体和它们的制备方法和它们作为杀菌剂的应用
公开(公告)号：EP0941988A3
公开(公告)日：2000-09-20
申请号：EP99104435.5
申请日：1999-03-05
发明人： Eicken, Karl, Dr. , Rheinheimer, Joachim, Dr. , Rose, Ingo, Dr. , Rack, Michael, Dr. , Ammermann, Eberhard, Dr. , Lorenz, Gisela, Dr. , Strathmann, Siegfried, Dr.
IPC分类号： C07C259/18 , C07C257/20 , A01N35/10
CPC分类号： C07C259/18 , A01N37/52 , C07C2601/02
摘要： Benzamidoxim-Derivate der Formel I in der die Substituenten die folgende Bedeutung haben: R 1 Fluor R 2 Phenyl-C 1 -C 6 -Alkyl, welches am Phenylring einen oder mehrere Substituenten ausgewählt aus der Gruppe bestehend aus Halogen, C 1 -C 4 -Alkyl, C 1 -C 4 -Halogenalkyl, C 1 -C 4 -Alkoxy oder C 1 -C 4 -Halogenalkoxy tragen kann, oder Thienyl-C 1 -C 4 -Alkyl, welches ggf. einen oder mehrere Substituenten ausgewählt aus der Gruppe bestehend aus Halogen, C 1 -C 4 -Alkyl, C 1 -C 4 -Halogenalkyl, C 1 -C 4 -Alkoxy oder C 1 -C 4 -Halogenalkoxy tragen kann, oder Pyrazol-C 1 -C 4 -Alkyl, welches ggf. einen oder mehrere Substituenten ausgewählt aus der Gruppe bestehend aus Halogen, C 1 -C 4 -Alkyl, C 1 -C 4 -Halogenalkyl, C 1 -C 4 -Alkoxy oder C 1 -C 4 -Halogenalkoxy tragen kann.
-
3.发明授权
公开(公告)号：EP3407717B1
公开(公告)日：2021-07-28
申请号：EP17744694.5
申请日：2017-01-18
发明人： BARTON, Thomas , GAO, Xin , HUNTER, Jim , LEPLAE, Paul, R. , LAWLER, Lori, K. , LO, William, C. , PETKUS, Jeff , BORUWA, Joshodeep , TANGIRALA, Raghuram , WATSON, Gerald, B. , HERBERT, John
IPC分类号： C07C255/46 , C07C257/20 , C07C259/14 , C07D213/75 , C07D331/04 , C07C327/48 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/78 , A01N29/12 , A01N31/04 , A01N33/04 , A01N35/04 , A01N37/10 , A01N37/20 , A01N37/26 , A01N43/20 , A01N43/36
-
公开(公告)号：EP2057117A2
公开(公告)日：2009-05-13
申请号：EP07837058.2
申请日：2007-08-20
发明人： CHEN, Shoujun , KOYA, Keizo , DEMKO, Zachary , SUN, Lijun
IPC分类号： C07C327/56 , A61K31/16 , A61P35/00 , C07C307/04 , C07C311/49 , C07C337/06 , C07C243/28 , C07C255/42 , C07C257/20 , C07C261/04 , C07D207/34 , C07D271/10 , C07D307/38 , C07F9/02
CPC分类号： C07C327/56 , A61K31/16 , A61K31/166 , A61K31/18 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/4245 , A61K31/664 , C07C243/28 , C07C243/34 , C07C255/66 , C07C257/22 , C07C261/04 , C07C281/06 , C07C307/04 , C07C311/49 , C07C311/51 , C07C311/55 , C07C337/06 , C07C2601/02 , C07D207/34 , C07D207/36 , C07D233/74 , C07D263/48 , C07D271/10 , C07D271/113 , C07D307/66 , C07F9/228 , C07F9/4423 , C07F9/4496 , C07F9/46
摘要： Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variabables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要翻译： （I），（III），（IV），（VII），（X），（XI），（XII），（XIII）和（XIV）的化合物，其中可变化物如权利要求中所定义。 以及使用本发明化合物治疗患有增殖性疾病如癌症的受试者的方法，以及治疗对Hsp70诱导和/或自然杀伤诱导有反应的疾病的方法。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物。
-
公开(公告)号：EP0922715B8
公开(公告)日：2008-05-21
申请号：EP98123058.4
申请日：1998-12-09
IPC分类号： C08F20/52 , C08F220/52 , C07C231/10 , C07C233/90 , C07C257/20
CPC分类号： G01N30/482 , B01J20/26 , B01J2220/54 , C07C231/08 , C07C231/10 , C07C233/18 , C08F20/52 , C08F220/52 , G01N30/54 , C07C233/90
-
6.发明授权
公开(公告)号：EP0929516B1
公开(公告)日：2002-09-18
申请号：EP97942007.2
申请日：1997-09-09
发明人： SCHROMM, Kurt , ANDERSKEWITZ, Ralf , RENTH, Ernst-Otto , BIRKE, Franz , JENNEWEIN, Hans, Michael , MEADE, Christopher, John, Montague
IPC分类号： C07C257/18 , C07C257/20 , C07C271/64 , A61K31/155
CPC分类号： C07D295/088 , C07C257/18 , C07C271/64
-
公开(公告)号：EP1203764A1
公开(公告)日：2002-05-08
申请号：EP02003690.1
申请日：1997-09-09
发明人： Schromm, Kurt , Anderskewitz, Ralf , Renth, Ernst-Otto , Birke, Franz , Jennewein, Hans Michael , Meade, Christopher, John, Montague
IPC分类号： C07C257/18 , C07C257/20 , C07C271/64 , A61K31/155 , A61P11/00
CPC分类号： C07D295/088 , C07C257/18 , C07C271/64
摘要： Benzamidinderivate der allergemeinen Formel (1)
worin
A -OC 2 -C 4 -Alkylen-O- oder -C 1 -C 3 -Alkylen-O-;
R 1 C 1 -C 6 -Alkyl, verzweigt oder unverzweigt, C 3 -C 6 -Alkenyl, verzweigt oder unverzweigt, vorzugsweise Allyl oder F, CI, Br, I;
R 2 Wasserstoff, C 1 -C 6 -Alkyl, verzweigt oder unverzweigt, C 3 -C 6 -Alkenyl, verzweigt oder unverzweigt, vorzugsweise Allyl oder F, CI, Br, I; mit LTB 4 -antagonistischer Wirkung.摘要翻译： 式（I）的苄脒衍生物及其盐是新的：A = O（2-4C亚烷基）O或（1-3C亚烷基）O; R1 = 1-6C烷基或卤素; R2 = H，1-6C烷基或卤素; R3，R4 = H，1-6C烷基，1-6C烷氧基，OH，CF3; 或R3 + R4 =稠合苯环的一部分（其可以被OH，1-4C烷基或1-4C烷氧基取代）; R5 = H，芳基，优选Ph，OPh，CR7R8，COPh或CH（OH）（其中Ph环可以被OH或1-4C烷氧基取代）或C（O）NR9R10; R6 = H，1-6C烷氧基羰基或1-6C酰基; 和R7-R10 = H或1-8C烷基。
-
8.发明授权
公开(公告)号：EP0779884B1
公开(公告)日：2000-05-03
申请号：EP95931216.6
申请日：1995-08-28
申请人： BAYER AG
发明人： KUHNT, Dietmar , HEINEMANN, Ulrich , GAYER, Herbert , GERDES, Peter , STETTER, Jörg , TIEMANN, Ralf , STENZEL, Klaus , DUTZMANN, Stefan
IPC分类号： C07C257/06 , C07C259/06 , C07C257/14 , C07C257/20 , C07D249/08 , C07D333/24 , A01N37/52 , A01N43/653 , A01N43/40 , A01N43/10
CPC分类号： C07D249/08 , A01N37/50 , A01N37/52 , A01N43/10 , A01N43/653 , A01N47/40 , C07C255/64 , C07C257/06 , C07C257/14 , C07C257/20 , C07D249/14
-
9.发明授权MALONAMIDE AND MALONAMIC ESTER DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY, THEIR PREPARATION AND THEIR USE 有权具有抗血栓作用，生产和使用MALONAMID-和丙二酯衍生物
公开(公告)号：EP1339673B1
公开(公告)日：2009-11-11
申请号：EP01974267.5
申请日：2001-09-20
IPC分类号： C07C257/18 , C07C257/20 , A61K31/155 , A61P7/02
CPC分类号： A61K31/27 , A61K31/167 , A61K31/225 , C07C257/18 , C07C257/20
摘要： The present invention relates to compounds of formula (I), in which R1, R1, A and B have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
-
公开(公告)号：EP0922715B1
公开(公告)日：2008-04-02
申请号：EP98123058.4
申请日：1998-12-09
IPC分类号： C08F20/52 , C08F220/52 , C07C231/10 , C07C233/90 , C07C257/20
CPC分类号： G01N30/482 , B01J20/26 , B01J2220/54 , C07C231/08 , C07C231/10 , C07C233/18 , C08F20/52 , C08F220/52 , G01N30/54 , C07C233/90
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.014 秒)
