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177 条记录 (耗时 0.018 秒)

    ENZYME REPLACEMENT THERAPY WITH 17-BETA-HYDROXYSTEROID DEHYDROGENASE-TYPE 2
    91.
    发明公开
    ENZYME REPLACEMENT THERAPY WITH 17-BETA-HYDROXYSTEROID DEHYDROGENASE-TYPE 2 审中-公开
    芝麻酱17-β-羟基脱氢酶脱氢酶2

    公开(公告)号：EP1616182A2

    公开(公告)日：2006-01-18

    申请号：EP04757538.6

    申请日：2004-03-17

    申请人： ETHICON, INC.

    发明人： GENSINI, Michel

    IPC分类号： G01N33/53

    CPC分类号： A61K51/1234 ,  A61K9/1271 ,  A61K38/191 ,  A61K38/2006 ,  A61K38/443 ,  A61K38/4886 ,  A61K47/6911 ,  A61K47/6913 ,  A61K48/005

    摘要： Compositions and methods for regulating the intra-conversion of estradiol/estrone or testosterone/androstenedione are provided herein. The compositions include a liposome carrier component; and a moiety externally attached thereto, which is targeted for a site in the body associated with aberrant production of estradiol or testosterone, or leaky blood vessels thereat. The inventive compositions also include an isolated or recombinant HSD-Type 2 polypeptide or nucleic acid form that is encapsulated by the liposome carrier component. The compositions are of use in overcoming the deficient expression of 17-β-hydroxysteroid dehydrogenase-Type 2 in endometriotic tissues. An HSD-Type 2 polypeptide or nucleic acid form can be delivered to a target cell, enzyme, or cytokine at the endometriotic implant site, or to leaky blood vessels within the implant. A label capable of external detection can be further included in the composition.

    Novel methods and medicament for treating infections diseases involving microbial biofilms
    95.
    发明公开
    Novel methods and medicament for treating infections diseases involving microbial biofilms 审中-公开
    这是基于微生物生物膜用于治疗感染的新方法和药物

    公开(公告)号：EP1068871A1

    公开(公告)日：2001-01-17

    申请号：EP99870145.2

    申请日：1999-07-07

    申请人： Perraudin, Jean-Paul

    发明人： Perraudin, Jean-Paul

    IPC分类号： A61K38/44 ,  A61K38/40 ,  A61K38/47 ,  A61K39/395 ,  A61K38/18

    CPC分类号： A61K38/443 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1891 ,  A61K38/40 ,  A61K38/44 ,  A61K38/47 ,  A61K39/395 ,  C12Y101/03004 ,  C12Y111/01007 ,  C12Y302/01017 ,  A61K2300/00

    摘要： The present invention provides the novel use of peroxidases, lactoferrin, lysozymes and immunoglobulins (used alone and/or combined) for the control of microbial biofilms after the action of growth factors (used alone and/or combined) on the epithelial and fibroblast cells to remove micro-organism biofilms adherent on cell surfaces. The present invention also relates to the use of peroxidases, lactoferrin, lysozymes and immunoglobulins (used alone and/or combined) in combination with growth factors (used alone and/or combined) for the preparation of medicaments for the prophylaxis or therapy of infectious diseases caused by microorganisms present in biofilms adherent on cell surfaces.

    摘要翻译： 本发明提供的新用途的过氧化物酶，乳铁蛋白，溶菌酶和免疫球蛋白的生长因子上的上皮细胞和成纤维细胞的作用（单独使用和/或组合）到后（单独使用和/或组合），用于微生物生物膜的控制 在细胞表面除去微生物生物膜粘附。 因此，本发明涉及使用过氧化物酶，乳铁蛋白，溶菌酶和免疫球蛋白在用生长因子组合（单独使用和/或组合）（单独使用和/或组合）用于制备药物的感染性疾病的预防或治疗 通过存在于贴壁细胞表面上的生物膜的微生物引起的。

    METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF SEXUALLY TRANSMITTED DISEASES
    97.
    发明公开
    METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF SEXUALLY TRANSMITTED DISEASES 失效
    方法和组合物的预防和治疗性疾病的

    公开(公告)号：EP0693934A1

    公开(公告)日：1996-01-31

    申请号：EP94914718.0

    申请日：1994-03-21

    申请人： EXOXEMIS, INC.

    发明人： ALLEN, Robert C.

    IPC分类号： A61K38 ,  A61P31

    CPC分类号： A61K38/443 ,  A61K2300/00

    摘要： Methods and compositions for the prophylaxis and/or treatment of sexually transmitted diseases (STDs) are disclosed, in which amounts of a haloperoxidase, such as myeloperoxidase or eosinophil peroxidase, and a semen substrate-specific oxidase are administered to a human or animal subject in the environment of sexually transmitted fluids. In the presence of semen, the semen substrate-specific oxidase catalyzes the production of hydrogen peroxide, which in turn is utilized by the haloperoxidase to selectively inhibit pathogenic microbes present in the sexually transmitted fluids. At high concentration levels, the compositions additionally exhibit spermicidal properties.

    HONEY-CANNABINOID THERAPEUTIC COMPOSITION
    100.
    发明公开
    HONEY-CANNABINOID THERAPEUTIC COMPOSITION 审中-公开

    公开(公告)号：EP3368033A1

    公开(公告)日：2018-09-05

    申请号：EP16859179.0

    申请日：2016-10-27

    申请人： Canabuzz-Med

    发明人： EYAL, Aharon M.

    IPC分类号： A61K31/352 ,  A23L21/00 ,  A23L21/25 ,  A61K31/00 ,  A61K31/35

    CPC分类号： A61K35/644 ,  A23L21/00 ,  A23L21/25 ,  A61K9/0014 ,  A61K9/0056 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61K38/443 ,  A61K45/06 ,  A61K2236/00 ,  A61K2300/00 ,  C12Y101/03004

    摘要： Honey-cannabinoid therapeutic compositions and methods. A therapeutic composition providing therapeutic effects to at least some patients is described including honey; at least one cannabinoid; and optionally, at least two non-cannabinoid cannabis compounds, hydrogen peroxide, at least one food-approved antioxidant, glucose oxidase, and/or catalase, and water; where the composition is homogeneous; has oxidative power low enough to keep tetrahydrocannabinol oxidation at a rate of less than 20% per month; contains hydrogen peroxide at a concentration low enough to keep tetrahydrocannabinol oxidation at a rate of less than 20% per month; contains at least one food-approved antioxidant at a concentration low enough to keep THC oxidation at a rate of less than 20% per month; contains glucose oxidase at a concentration low enough to keep tetrahydrocannabinol oxidation at a rate of less than 20% per month; and/or contains catalase at a concentration high enough to keep tetrahydrocannabinol oxidation at a rate of less than 20% per month.