公开(公告)号：EP2202510B1

公开(公告)日：2018-05-30

申请号：EP09180505.1

申请日：2001-08-29

申请人： Ethrog Biotechnology Ltd.

发明人： Cabilly, Shmuel ,  Margalit, Ilana ,  Yogev, Uri

IPC分类号： G01N27/26 ,  G01N27/447

CPC分类号： G01N27/44713 ,  G01N27/44743 ,  G01N27/44782

摘要： The present invention includes apparatus (10) for simultaneous loading of multiple samples for molecular separation, including a separation area (11) with walls (12, 14, 16) wherein at least one of the walls has apertures (38) having loading sites, a gel (18) located within the separation area, and a plurality of wells (36) within the gel. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells. The present invention further includes apparatus for electrophoresis separation having a substantival closed electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in a stagger format.

公开(公告)号：EP3032251B1

公开(公告)日：2018-05-23

申请号：EP15191406.6

申请日：2008-04-04

申请人： Ande Corporation

发明人： Tan, Eugene ,  Kan, Cheuk Wai ,  Lam, Heung Chuan

IPC分类号： G01N27/447 ,  C12Q1/68 ,  B01L3/00 ,  G01N21/64 ,  B01L7/00

CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/1894 ,  B01L2400/0421 ,  C12Q1/686 ,  C12Q1/6869 ,  G01N21/6402 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6486 ,  G01N27/44726 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2021/6441 ,  G01N2201/06113 ,  Y10T436/2575

摘要： Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip described.

公开(公告)号：EP3079821B1

公开(公告)日：2018-05-09

申请号：EP14805250.9

申请日：2014-11-26

申请人： GE Healthcare Bio-Sciences AB

发明人： SODERMAN, Tobias, Ingemar ,  NORRMAN, Nils ,  OSTLIN, Henrik ,  LINDMAN, Susanna ,  BERGMAN, David, Carl, Martin ,  OLIVIUSSON, Peter, Mats

IPC分类号： B01L3/00 ,  G01N21/07 ,  G01N35/00 ,  G01N27/447 ,  G01N35/04

CPC分类号： B01L3/5025 ,  B01L3/502 ,  B01L3/5085 ,  B01L3/50855 ,  B01L2200/028 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2300/0803 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0478 ,  G01N21/07 ,  G01N27/44739 ,  G01N35/00 ,  G01N35/1065 ,  G01N2035/00108 ,  G01N2035/0439

摘要： The present invention provides methods and systems for eluting and an analyte from a solid phase. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a solid phase to a second vessel, such as a microtitre plate well. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.

公开(公告)号：EP3260845A3

公开(公告)日：2018-05-02

申请号：EP17168073.9

申请日：2017-04-25

申请人： Fujifilm Corporation

发明人： KOBAYASHI, Takashi

IPC分类号： G01N21/64 ,  G01T1/20 ,  G01N27/447

CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N21/6486 ,  G01N27/44717 ,  G01N27/44721 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2201/06193 ,  G01N2201/11

摘要： There are provided a control device of an image reading apparatus, an operation method and an operation program thereof, and an image detection system capable of quickly and easily outputting an image having an appropriate density for analysis from an image reading apparatus. An image receiving unit (80) receives a pre-image output in pre-scanning performed before main scanning for outputting a main image for analysis in an image reading apparatus (11). A region information receiving unit (81) receives information of a region in the pre-image designated by a user. A calculation unit (83) calculates an appropriate voltage value (HVM) that is a voltage value of the photomultiplier (31) at which a density of the region becomes an appropriate density for analysis. A scanning conditions setting unit (84) sets the appropriate voltage value (HVM) as temporary scanning conditions (76M) of main scanning.

摘要翻译： 提供了图像读取装置的控制装置，其操作方法和操作程序以及图像检测系统，其能够从图像读取装置快速且容易地输出具有适当分辨率的图像。 图像接收单元（80）接收在主扫描之前执行的预扫描中输出的预图像输出，以在图像读取装置（11）中输出用于分析的主图像。 区域信息接收单元（81）接收用户指定的预先图像中的区域的信息。 计算单元（83）计算作为光电倍增管（31）的电压值的适当电压值（HVM），在该电压值处该区域的密度变为用于分析的适当密度。 扫描条件设定部（84）将适当的电压值（HVM）设定为主扫描的临时扫描条件（76M）。

公开(公告)号：EP3295160A1

公开(公告)日：2018-03-21

申请号：EP16724222

申请日：2016-05-10

申请人： UNIV NORTH CAROLINA CHAPEL HILL

发明人： MELLORS JOHN SCOTT ,  REDMAN ERIN ANNE ,  RAMSEY JOHN MICHAEL

IPC分类号： G01N27/447 ,  B01L3/00 ,  G01N30/72

CPC分类号： G01N27/44743 ,  B01L3/50273 ,  B01L2300/0864 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0622 ,  B01L2400/0666 ,  B05B5/00 ,  G01N27/4473 ,  G01N27/44791 ,  G01N30/7266 ,  H01J49/165

摘要： Methods that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer.

公开(公告)号：EP3294125A1

公开(公告)日：2018-03-21

申请号：EP16792263

申请日：2016-01-22

申请人： INDIAN INST SCIENT

发明人： KUMAR VINAY ,  BHAT NAVAKANTA ,  KASHYAP DHANVANTARI MADHURESH NIKHILA

IPC分类号： A61B5/05 ,  C07K14/76 ,  G01N27/327 ,  G01N27/447 ,  G01N33/48 ,  G01N33/493

CPC分类号： G01N27/327 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/207 ,  A61B10/007 ,  C07K14/76 ,  G01N33/493 ,  G01N33/5438 ,  G01N2333/765

摘要： An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (ACR). The present invention also provides an electrochemically active, creatinine-binding and albumin-binding device, for collection and retention of biological samples, having creatinine and albumin bioanalytes. In the present invention, a device holder is provided to receive the electrochemically active, creatinine-binding and albumin-binding device. The device, point-of-care biosensor and the method of the present invention, facilitate quantitative measurement of creatinine and albumin bioanalytes in urine and blood samples, and albumin to creatinine ratio (ACR), in urine samples, electrochemically, by determining redox current values.

公开(公告)号：EP2005148B1

公开(公告)日：2018-03-07

申请号：EP07710757.1

申请日：2007-03-16

申请人： Universal Nanosensor Technologies Inc.

发明人： Dhirani, Al-Amin ,  Suganuma, Yoshinori

IPC分类号： G01N27/22 ,  G01N27/447 ,  G01N30/64 ,  G01R27/26

CPC分类号： G01N30/64 ,  G01N27/3278 ,  G01N2030/645

摘要： Sensing device and method for detecting presence and concentration of generic target analytes of interest. The device and method are based on detecting changes in effective dielectric induced by the target analytes of interest. Applications of the invention include, but are not restricted to, detecting and characterizing the presence of chemical and/or biological target analytes of interest as well as detecting and characterizing target analytes of interest from a separation apparatus. In one embodiment of the invention, the device comprises at least two electrodes in a rigid architecture such as a solid surface, where the electrodes have sizes and inter-electrode spacings that are on the order of sizes of target analytes of interest to improve sensitivity of the device. Changes in effective dielectric and, therefore, capacitance induced by a presence of the target analytes of interest are measured electronically. The changes are used to detect the presence of the target analytes of interest and to characterize their presence.

公开(公告)号：EP2721182B1

公开(公告)日：2018-02-21

申请号：EP12801329.9

申请日：2012-06-15

申请人： British Columbia Cancer Agency Branch

发明人： COOPE, Robin J. Noel ,  SLOBODAN, Jared Raymond

IPC分类号： C12Q1/68 ,  C12M1/34 ,  C12M1/42 ,  C12N15/10 ,  G01N27/447

CPC分类号： G01N27/44721 ,  G01N27/44739

摘要： Apparatus and methods for size selecting nucleic acid molecules having wide range of applications including the production of DNA libraries for sequencing technologies. An automated high throughput system for size selection of multiple nucleic acid samples that uses imaging technique to detect the progress of a target fraction and feedback from the imaging to control electrophoresis. Predictive algorithms for timed nucleic acid extractions are generated to provide size selected nucleic acid molecules of required size ranges.

公开(公告)号：EP3282251A1

公开(公告)日：2018-02-14

申请号：EP16776275.6

申请日：2016-03-25

申请人： Panasonic Intellectual Property Management Co., Ltd.

发明人： OKA, Hiroaki ,  YANAGIDA, Takeshi ,  HAYASHI, Nobuhiro

IPC分类号： G01N27/447

CPC分类号： G01N27/44795 ,  G01N27/44721 ,  G01N27/44747 ,  G01N27/44773

摘要： An object is to provide an electrophoretic support body and an electrophoretic device which allow a potential of hydrogen (pH) to be easily and reproducibly adjusted. The electrophoretic support body in the present disclosure is an electrophoretic support body including a plurality of fibers, the plurality of fibers form a fibrous body having a void in the fibrous body, and the plurality of fibers include a metal oxide having a predetermined isoelectric point. The electrophoretic device in the present disclosure includes a container, a pair of first electrodes provided in the container, and a first electrophoretic support body disposed between the pair of first electrodes, the first electrophoretic support body includes a fibrous body that is formed of a plurality of fibers and has a void in the fibrous body, and the plurality of fibers include a metal oxide having a predetermined isoelectric point.

摘要翻译： 本发明的目的是提供一种电泳支持体和电泳装置，其允许容易和可再现地调节氢（pH）的电位。 本发明中的电泳支撑体是包括多根纤维的电泳支撑体，多根纤维形成在纤维体中具有空隙的纤维体，并且多根纤维包括具有预定等电点的金属氧化物。 本发明的电泳装置包括容器，设置在该容器内的一对第一电极以及设置在该一对第一电极之间的第一电泳支撑体，该第一电泳支撑体包括纤维体，该纤维体由多个 并且在纤维体中具有空隙，并且所述多根纤维包括具有预定等电点的金属氧化物。

公开(公告)号：EP3265796A2

公开(公告)日：2018-01-10

申请号：EP16715229.7

申请日：2016-03-07

申请人： 4D Lifetec AG

发明人： SCHICHT, Oliver

IPC分类号： G01N27/447

CPC分类号： G01N27/44782 ,  B01L9/54 ,  B01L2300/0829 ,  G01N27/44704 ,  G01N27/44708

摘要： The invention relates to a gel electrophoresis apparatus for single cell gel electrophoresis, comprising a chamber (7a) for receiving a gel electrophoresis buffer, a functional cover (7b) for closing the chamber, at least one pair of electrodes (8, 8') for generating a homogeneous electric field in the chamber and at least one retaining element (6) for receiving and positioning at least one support plate (1). The at least one retaining element (6) positions the at least one support plate (1) in the homogeneous electric field generated by the at least one pair of electrodes (8, 8").