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116 条记录 (耗时 0.044 秒)

    NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE
    101.
    发明公开
    NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
    NITRO和镀锌亚硝基化合物心血管，组合物及使用方法

    公开(公告)号：EP1670459A2

    公开(公告)日：2006-06-21

    申请号：EP04781569.1

    申请日：2004-08-20

    申请人： Nitromed, Inc.

    发明人： GARVEY, David, S. ,  LETTS, Gordon, L. ,  WORCEL, Manuel ,  GASTON, Ricky, D.

    IPC分类号： A61K31/405 ,  A61K31/44 ,  A61K31/535 ,  C07D209/04 ,  C07D221/02 ,  C07D415/00

    CPC分类号： C07D493/04 ,  C07D407/04 ,  C07K5/06026

    摘要： The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at,least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated P-adrenergic antagonists, nitrosated and/or nitrosylated angiotensin­converting enzyme (ACE) inhibitors, nitrosated and/or nitrosylated anti-hyperlipidemic compounds, and nitrosated and/or nitrosylated antithrombotic and vasodilator compounds.

    NITROSATED AND/OR NITROSYLATED CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE
    104.
    发明公开
    NITROSATED AND/OR NITROSYLATED CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE 审中-公开
    NITRO镀锌和/或亚硝基化环氧合酶-2选择性抑制剂，组合物和使用方法

    公开(公告)号：EP1539134A2

    公开(公告)日：2005-06-15

    申请号：EP03757428.2

    申请日：2003-06-10

    申请人： Nitromed, Inc.

    发明人： LETTS, L., Gordon ,  GARVEY, David, S.

    IPC分类号： A61K31/34

    CPC分类号： C07D295/185 ,  A61K45/06 ,  C07C229/42 ,  C07C317/18 ,  C07C323/12 ,  C07D493/04

    摘要： The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or, optionally, at least one therapeutic agent. The invention also provides novel compositions comprising at least one COX-2 selective inhibitor, that is optionally sitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors. The invention also provides novel kits comprising at least one COX-2 selective inhibitor optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention are preferably 2(2-((2-chloro-6-fluorophenyl) amino)5-methylphenyl)acetic acid and nitrosated derivatives thereof.

    NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE
    106.
    发明公开
    NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE 审中-公开
    氮氧化物捐助者和组合物的方法

    公开(公告)号：EP1497268A2

    公开(公告)日：2005-01-19

    申请号：EP03719621.9

    申请日：2003-04-07

    申请人： Nitromed, Inc.

    发明人： FANG, Xinqin ,  GARVEY, David, S. ,  GASTON, Ricky, D. ,  LIN, Chia-En ,  RANATUNGA, Ramani, R. ,  RICHARDSON, Stewart, K. ,  WANG, Tiansheng ,  WANG, Weiheng ,  WEY, Shiow-Jyi

    IPC分类号： C07D235/00

    CPC分类号： C07D213/74 ,  C07C313/36 ,  C07C2602/08 ,  C07C2602/42 ,  C07C2603/74 ,  C07D211/54 ,  C07D217/02 ,  C07D233/96 ,  C07D239/47 ,  C07D241/08 ,  C07D241/24 ,  C07D295/155 ,  C07D317/22 ,  C07D453/02 ,  C07F9/383 ,  C07F9/4018

    摘要： The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.

    NITROSATED AND NITROSYLATED NEBIVOLOL AND ITS METABOLITES, COMPOSITIONS AND METHODS OF USE
    108.
    发明公开
    NITROSATED AND NITROSYLATED NEBIVOLOL AND ITS METABOLITES, COMPOSITIONS AND METHODS OF USE 有权
    亚硝化和亚硝基化奈必洛尔及其代谢物和组合物的方法

    公开(公告)号：EP1406608A2

    公开(公告)日：2004-04-14

    申请号：EP02766876.3

    申请日：2002-05-01

    申请人： Nitromed, Inc.

    发明人： GARVEY, David, S.

    IPC分类号： A61K31/352 ,  C07D311/04

    CPC分类号： A61K31/353 ,  C07D311/22 ,  C07D311/58

    摘要： The invention describes novel nitrosated and/or nitrosylated nebivolol, novel nitrosated and/or nitrosylated metabolites of nebivolol and novel compositions comprising at least one nitrosated and/or nitrosylated nebivolol and/or at least one nitrosated and/or nitrosylated metabolite of nebivolol, and optionally, at least one nitric oxide donor and/or at least one antioxidant or a pharmaceutically acceptable salt thereof, and/or at least one compound used to treat cardiovascular disease or a pharmaceutically acceptable salt thereof, and/or at least one nitrosated compound used to treat cardiovascular diseases. The invention also provides novel compositions comprising nebivolol and/or at least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a pharmaceutically acceptable salt thereof, and/or at least one compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof, and/or at least one nitrosated compound used to treat cardiovascular diseases. The compounds and compositions of the invention can also be bound to a matrix. The nitric oxide donor is a compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and may preferably be isosorbide dinitrate and/or isosorbide mononitrate. The antioxidant may preferably be a hydralazine compound or a pharmaceutically acceptable salt thereof. The invention also provides methods for treating and/or preventing vascular diseases characterized by nitric oxide insufficiency; and for treating and/or preventing Raynaud's syndrome; and for treating and/or preventing cardiovascular diseases or disorders.