公开(公告)号：EP1310166A4

公开(公告)日：2004-06-16

申请号：EP01936924

申请日：2001-06-08

申请人： TAKEDA JUNJI

发明人： TAKEDA J ,  HORIE K

IPC分类号： A01K67/027 ,  C12N5/10 ,  C12N9/22 ,  C12N15/09 ,  C12N15/85 ,  C12Q1/68 ,  C12R1/91 ,  C12N15/90

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2217/20 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/02 ,  A01K2267/025 ,  A01K2267/03 ,  A01K2267/0393 ,  C12N9/22 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2800/90 ,  C12N2830/006 ,  C12N2840/20 ,  C12N2840/203 ,  C12N2840/44

摘要： A transgenic non-human mammal containing non-integrated transposon and/or transposase gene.

公开(公告)号：EP1425400A2

公开(公告)日：2004-06-09

申请号：EP02773370.8

申请日：2002-09-12

申请人： California Institute of Technology

发明人： BALTIMORE, David ,  HONG, Elizabeth, J. ,  LOIS-CABALLE, Carlos ,  PEASE, Shirley

IPC分类号： C12N15/63 ,  C12N15/85 ,  C12N15/00 ,  A01K67/00

CPC分类号： C12N15/86 ,  A01K2217/05 ,  A01K2227/30 ,  A01K2227/40 ,  A61K38/00 ,  A61K48/00 ,  C12N15/1132 ,  C12N15/1138 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2740/16043 ,  C12N2800/60 ,  C12N2830/003 ,  C12N2830/006 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203 ,  C12N2840/44 ,  Y02A50/463 ,  Y02A50/465

摘要： The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated.

摘要翻译： 本发明涉及用转基因动物，特别是转基因大鼠生产用于携带感兴趣的转基因的逆转录病毒构建体的方法。

公开(公告)号：EP1373524A2

公开(公告)日：2004-01-02

申请号：EP01979785.1

申请日：2001-10-12

申请人： CHIRON CORPORATION

发明人： THUDIUM, Kent ,  SELBY, Mark ,  ULMER, Jeffrey

IPC分类号： C12N15/63

CPC分类号： C12N15/85 ,  C12N7/00 ,  C12N15/67 ,  C12N2710/16622 ,  C12N2830/42 ,  C12N2830/60 ,  C12N2840/44 ,  C12N2840/445

摘要： Cytomegalovirus (CMV) Intron A fragments for expressing gene products are disclosed. Also described are expression vectors including the fragments, as well as methods of using the same.

公开(公告)号：EP1356111A2

公开(公告)日：2003-10-29

申请号：EP01992785.4

申请日：2001-10-30

申请人： Geneart GmbH

发明人： WAGNER, Ralf ,  GRAF, Marcus

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  C12N5/10 ,  C12N15/10 ,  C12N15/62

CPC分类号： C12N15/1051 ,  C12N15/1075 ,  C12N15/85 ,  C12N2840/44 ,  C12Q1/6897

摘要： The invention relates to reporter systems for RNA export, to a method for locating molecules which influence RNA export and to a technique for detecting a virus infection which is based on this method.

公开(公告)号：EP1310558A3

公开(公告)日：2003-08-13

申请号：EP03000252.1

申请日：1994-02-02

申请人： XOMA Technology Ltd.

发明人： Theofan, Georgia ,  Horwitz, Arnold ,  Burke, David ,  Baltaian, Manik ,  Grinna, Lynn

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12N5/10

CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/4742 ,  C07K2319/00 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use in treatment of gram negative bacterial infection and its sequelae.

公开(公告)号：EP1295952A3

公开(公告)日：2003-07-09

申请号：EP02026164.0

申请日：1997-01-23

申请人： The Board of Trustees of The Leland Stanford Junior University ,  Rigel Pharmaceuticals, Inc.

发明人： Noaln, Garry P., Stanford University ,  Rothenberg, S. Michael, Stanford University

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  C12N7/00 ,  C12N5/10 ,  C07K1/04

CPC分类号： C12N15/1082 ,  C07K1/047 ,  C12N15/1034 ,  C12N15/1079 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2799/027 ,  C12N2830/00 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203 ,  C12N2840/44 ,  C12Q1/6811 ,  C12Q1/6897 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/68 ,  G01N33/6803 ,  G01N2500/00 ,  G01N2510/00

摘要： Methods and compositions for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.

摘要翻译： 提供了用于筛选在随机化池内活细胞内选择的跨主效效应肽和RNA分子的方法和组合物。

公开(公告)号：EP1317560A1

公开(公告)日：2003-06-11

申请号：EP01968599.9

申请日：2001-09-07

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： SEED, Brian ,  WRIGHT FREEMAN, Mason ,  KOVTUN, Alexander ,  MURAKAWA, Masahiro ,  PARK, Eun-Chung ,  WANG, Xinzhong

IPC分类号： C12N15/86 ,  C12N15/861 ,  C12N5/10 ,  C12N15/11 ,  C12N15/63 ,  C12N15/64 ,  C12N15/65 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N15/63 ,  C12N15/635 ,  C12N2710/10343 ,  C12N2800/108 ,  C12N2800/30 ,  C12N2830/006 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/205 ,  C12N2830/38 ,  C12N2830/85 ,  C12N2840/203 ,  C12N2840/44

摘要： Disclosed are replicatable viral DNA vectors encoding a site-specific DNA-altering enzyme and a DNA target recognized by the enzyme, the enzyme selectively converting, in a cell expressing the enzyme, the DNA vector to a rearranged form. The invention further relates to methods for assembling recombinant adenoviral DNAs. These methods include the steps of: providing a first linearized DNA vector including a restriction site and a cos site and a second linearized DNA vector including the restriction site, an adenoviral nucleic molecule, and a cos site; and ligating the first and second linearized DNA vectors, the ligation assembling a recombinant adenoviral DNA.

公开(公告)号：EP1246946A4

公开(公告)日：2003-05-28

申请号：EP01984619

申请日：2001-10-26

申请人： BIONAUT PHARMACEUTICALS

发明人： KHODADOUST MEHRAN M

IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07H21/04 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/11 ,  C12N15/74 ,  C12N15/85 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

CPC分类号： C12N15/85 ,  C12N2800/30 ,  C12N2800/60 ,  C12N2830/003 ,  C12N2840/206 ,  C12N2840/44 ,  C12Q1/6897

公开(公告)号：EP1310558A2

公开(公告)日：2003-05-14

申请号：EP03000252.1

申请日：1994-02-02

申请人： XOMA Technology Ltd.

发明人： Theofan, Georgia ,  Horwitz, Arnold ,  Burke, David ,  Baltaian, Manik ,  Grinna, Lynn

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12N5/10

CPC分类号： C07K19/00 ,  A61K38/00 ,  C07K14/4742 ,  C07K2319/00 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

摘要： Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use in treatment of gram negative bacterial infection and its sequelae.

摘要翻译： 本发明公开了新颖的杀菌/通透性增强（BPI）蛋白worin半胱氨酸残基号码132或135被另一氨基酸残基取代，优选为丙氨酸或丝氨酸残基和/或在193位worin的亮氨酸残基是羧基末端残基的产品。 所以圆盘游离缺失是编码用于在适当的宿主细胞中产生其的方法的DNA序列，以及含有适合用于治疗革兰氏阴性细菌感染及其后遗症的用途类似物稳定均匀的药物组合物。

公开(公告)号：EP0632129B1

公开(公告)日：2003-04-16

申请号：EP94107918.8

申请日：1994-05-24

申请人： BAYER AG

发明人： ter Meulen, Volker, Prof.Dr. ,  Rethwilm, Axel, Dr.

IPC分类号： C12N15/86 ,  A61K48/00 ,  C12N5/10 ,  C12N15/48

CPC分类号： C07K14/005 ,  C12N15/86 ,  C12N2740/17022 ,  C12N2740/17043 ,  C12N2840/203 ,  C12N2840/44 ,  C12N2840/85