公开(公告)号：EP3053592A4

公开(公告)日：2017-09-06

申请号：EP14850811

申请日：2014-10-01

申请人： UNIV MIE ,  UNIV KYOTO

发明人： SHIKU HIROSHI ,  HARADA NAOZUMI ,  MURAOKA DAISUKE ,  AKIYOSHI KAZUNARI

IPC分类号： A61K39/00 ,  A61K9/00 ,  A61K39/015 ,  A61K39/12 ,  A61K47/36 ,  A61K48/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07K14/00

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61K39/015 ,  A61K39/12 ,  A61K47/36 ,  A61K2039/55583 ,  A61K2039/6087 ,  C12N2710/16122 ,  C12N2710/16134

公开(公告)号：EP3209325A2

公开(公告)日：2017-08-30

申请号：EP15747523.7

申请日：2015-07-30

申请人： Oxford University Innovation Limited

发明人： DRAPER, Simon ,  HIGGINS, Matthew ,  WRIGHT, Katherine ,  DOUGLAS, Alexander

IPC分类号： A61K39/015 ,  C07K16/20

CPC分类号： A61K39/015 ,  A61K39/005 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/445 ,  C07K16/205 ,  C07K2319/02 ,  C12N7/00 ,  C12N15/115 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2710/24033 ,  C12N2710/24034 ,  Y02A50/412

摘要： There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising fragments of Reticulocyte-binding protein Homologue 5 (PfRH5). In particular, the invention provides fragments of PfRH5 rationally designed on the basis of the PfRH5 crystal structure, wherein said fragments which lack disordered regions, particularly the flexible N-terminal region and/or flexible central linker.

摘要翻译： 提供了抗原，编码抗原的载体，抗体和抗原的其他结合化合物及其在预防或治疗疟疾中的用途。 具体而言，提供了包含网织红细胞结合蛋白同源物5（PfRH5）的片段的组合物。 具体而言，本发明提供了基于PfRH5晶体结构合理设计的PfRH5片段，其中所述片段缺乏无序区域，特别是柔性N-末端区域和/或柔性中央接头。

公开(公告)号：EP3191122A1

公开(公告)日：2017-07-19

申请号：EP15759742.8

申请日：2015-09-02

申请人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung E.V.

发明人： SPIEGEL, Holger ,  BOES, Alexander ,  EDGÜ, Güven ,  BEISS, Veronique ,  SACK, Markus ,  REIMANN, Andreas ,  FISCHER, Rainer

IPC分类号： A61K39/015 ,  C12N15/62 ,  A61K39/00

CPC分类号： A61K39/015 ,  A61K2039/575 ,  A61K2039/64 ,  A61K2039/70 ,  C07K14/445 ,  C07K16/205 ,  C07K2319/00 ,  C07K2319/40 ,  C12N15/62 ,  Y02A50/412

摘要： The technology provided herein relates to novel malaria vaccines composed of different recombinant proteins, in particular recombinant fusion proteins comprising several different Plasmodium falciparum antigens from the pre-erythrocytic, the blood, and the sexual parasite main stages. The proteins may be used in a mixture vaccine formulation to elicit protective immune responses in humans. Nucleic acid molecules encoding said recombinant proteins, vectors and host cells containing the nucleic acids and methods for preparation and producing such proteins are also disclosed, as well as antibodies induced or generated by the use of said malaria vaccines and the use of such antibodies or recombinant derivatives for passive immunotherapy.

摘要翻译： 本文提供的技术涉及由不同重组蛋白质组成的新型疟疾疫苗，特别是包含来自红细胞前期，血液和性寄生虫主要阶段的几种不同疟原虫恶性疟原虫抗原的重组融合蛋白。 蛋白质可用于混合疫苗制剂中以在人体内引发保护性免疫应答。 还公开了编码所述重组蛋白质的核酸分子，含有该核酸的载体和宿主细胞，以及制备和生产这些蛋白质的方法，以及使用所述疟疾疫苗诱导或产生的抗体，以及使用这些抗体或重组体 被动免疫治疗的衍生物。

公开(公告)号：EP3137106A1

公开(公告)日：2017-03-08

申请号：EP15786133.7

申请日：2015-05-01

申请人： Sanaria Inc.

发明人： EAPPEN, Abraham G. ,  HOFFMAN, Stephen L.

IPC分类号： A61K39/015

CPC分类号： A61K39/015 ,  A61K2039/52 ,  A61K2039/522 ,  C12N1/10 ,  Y02A50/412

摘要： The application is directed to in-vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.

摘要翻译： 本申请涉及人类宿主范围的体外培养的疟原虫子孢子及其制备方法，其中从配子母细胞阶段到孢子体阶段的孢子体在蚊子外部。 本文提供了人体宿主范围的体外培养的感染性疟原虫子孢子（SPZ），特别是恶性疟原虫，间日疟原虫，卵形疟原虫，疟疾和疟原虫，其中从配子母细胞阶段到子孢子阶段的孢子体是外部的 蚊子及其制造方法。

公开(公告)号：EP2714075B1

公开(公告)日：2016-11-16

申请号：EP12793152.5

申请日：2012-05-28

申请人： Griffith University ,  La Trobe University ,  Lee, Moses

发明人： LEE, Moses ,  GOOD, Michael ,  SPITHILL, Terry

IPC分类号： A61K39/015 ,  A61P33/06

CPC分类号： A61K39/015 ,  A61K2039/522 ,  C07K14/445 ,  Y02A50/412

摘要： An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin A. The immunogenic composition does not include an adjuvant. A single dose of the immunogenic composition is sufficient to protect an animal against subsequent malaria infection by the same isolate, strain or species of Plasmodium used in the immunogenic composition, or by one or more heterologous isolates, strains or species of Plasmodium.

公开(公告)号：EP2277533B1

公开(公告)日：2016-07-20

申请号：EP10163236.2

申请日：2003-10-22

申请人： GlaxoSmithKline Biologicals S.A. ,  The United States of America as represented by The Secretary of The Navy

发明人： Hoffman, Stephen L. ,  Wang, Ruobing ,  Epstein, Judith E. ,  Cohen, Joseph D.

IPC分类号： A61K39/015 ,  C07K14/445 ,  A61P33/06 ,  G01N33/53

CPC分类号： A61K39/015 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  C07K14/445 ,  Y02A50/412 ,  Y02A50/58

摘要： The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine, and boosting that response with a protein-based vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.

公开(公告)号：EP2988776A1

公开(公告)日：2016-03-02

申请号：EP14719741.2

申请日：2014-04-24

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： BOES, Alexander ,  SPIEGEL, Holger ,  GÜVEN, Edgü ,  BEISS, Veronique ,  SACK, Markus ,  REIMANN, Andreas ,  FISCHER, Rainer

IPC分类号： A61K39/002 ,  A61K39/015 ,  C12N15/62

CPC分类号： C07K14/445 ,  A61K39/002 ,  A61K39/015 ,  C07K2319/00 ,  C07K2319/40 ,  C12N15/62 ,  Y02A50/412

摘要： The technology provided herein generally relates to novel fusion proteins suitable as human and/or animal vaccines against parasites or pathogens of the phylum Apicomplexa. In particular, the present disclosure relates to novel fusion proteins as a basis for vaccines against Plasmodium parasites, including P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. Nucleic acid molecules encoding said fusion proteins, vectors, host cells containing the nucleic acids and methods for preparation and producing such fusion proteins; antibodies induced or generated by the use of said fusion proteins or said nucleic acid molecules encoding said fusion proteins and the use of such antibodies or recombinant derivatives for passive immunotherapy; methods for producing such fusion proteins; compositions and methods for using such fusion proteins for the prevention and treatment of malaria are also encompassed by the present disclosure.

摘要翻译： 本文提供的技术通常涉及适用于针对Apicomplexa门的寄生虫或病原体的人和/或动物疫苗的新型融合蛋白。 特别地，本公开内容涉及新颖的融合蛋白作为针对疟原虫寄生虫的疫苗的基础，包括恶性疟原虫，间日疟原虫，马鞭草，疟原虫和know know属。 编码所述融合蛋白的核酸分子，载体，含有核酸的宿主细胞和用于制备和产生此类融合蛋白的方法; 通过使用所述融合蛋白或编码所述融合蛋白的所述核酸分子诱导或产生的抗体以及所述抗体或重组衍生物用于被动免疫治疗的用途; 生产这种融合蛋白的方法; 用于预防和治疗疟疾的这种融合蛋白的组合物和方法也包括在本公开中。

公开(公告)号：EP2916862A2

公开(公告)日：2015-09-16

申请号：EP13795397.2

申请日：2013-11-12

申请人： GenVec, Inc.

发明人： CHEN, Ping ,  MCVEY, Duncan ,  BROUGH, Douglas ,  BRUDER, Joseph

IPC分类号： A61K39/015

CPC分类号： A61K39/015 ,  A61K2039/5256 ,  A61K2039/53 ,  Y02A50/412

摘要： The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against Plasmodium species that infect humans. The invention also is directed to a method of using such compositions to induce a protective immune response against a Plasmodium parasite in a mammal.

公开(公告)号：EP2785369A4

公开(公告)日：2015-07-01

申请号：EP12854261

申请日：2012-11-30

申请人： UNIV CALIFORNIA

发明人： FELGNER PHILIP ,  LIANG XIAOWU ,  SAUERWEIN ROBERT

IPC分类号： A61K39/015 ,  A61P37/00 ,  C07K14/445

CPC分类号： C07K14/43563 ,  A61K39/015 ,  A61K2039/70

摘要： Contemplated compositions and methods employ selected antigens form Plasmodium falciparum and can be used as a vaccine, therapeutic agent, and/or diagnostic tool. Especially preferred antigens are post-challenge immunity associated antigens that are identified via pre-infection suppressive treatment, controlled sub-symptomatic infection to develop immunity, and comparative proteomic differential analysis.

公开(公告)号：EP1545599B1

公开(公告)日：2015-04-29

申请号：EP03737755.3

申请日：2003-07-25

申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH

发明人： SCHOFIELD, Louis

IPC分类号： A61K39/015 ,  A61K39/395 ,  A61P33/00

CPC分类号： C07K16/205 ,  A61K31/739 ,  A61K39/015 ,  A61K2039/505 ,  Y02A50/412

摘要： The present invention relates to a method of inducing an immune response to a parasite utilizing an immunogenic composition comprising a glycosylphosphatidylinositol (“GPI”) inositolglycan domain or its derivative or equivalent. The present invention is useful as a prophylactic and/or therapeutic treatment for microorganism infections of mammals such as parasite infections and particularly infection by Plasmodium species. The invention also provides a method of monitoring, or qualitatively or quantitatively assessing an immune response to a microorganism such as a parasite. More particularly, this aspect of the present invention is directed to assessing said immune response utilizing a GPI inositoglycan domain or its derivative or equivalent, which facilitates the qualitative and/or quantitative analysis of anti-GPI antibodies in a biological sample, the identification of unique specificities of antibodies, epitope specific screening or the rational design of immunogenic molecules and the generation, thereby, of functionally effective immunointeractive molecules.