公开(公告)号：EP1167377B1

公开(公告)日：2009-01-07

申请号：EP01202811.4

申请日：1995-02-07

申请人： University of Iowa Research Foundation ,  United States of America, as represented by the Secretary, Department of Health and Human Services ,  Coley Pharmaceutical Group, Inc.

发明人： Krieg, Arthur, M. ,  Klinman, Dennis ,  Steinberg, Alfred D.

IPC分类号： C12N15/11 ,  C07H21/00 ,  A61K31/7088

CPC分类号： A61K31/70 ,  A61K31/7125 ,  A61K39/39 ,  A61K2039/55561 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12Q1/68

公开(公告)号：EP2008101A2

公开(公告)日：2008-12-31

申请号：EP07760046.8

申请日：2007-04-03

申请人： University of Iowa Research Foundation ,  Complementum Ltd.

发明人： HAGEMAN, Gregory S. ,  MERI, Seppo

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N33/566 ,  G01N2800/16

摘要： The invention relates to a correlation between serum complement Factor H levels and binding to C-reactive protein (CRP) and risk of developing age-related macular degeneration. The invention provides methods for screening a subject to assess risk of developing AMD. The invention also provides methods for screening for agents useful to treat AMD.

公开(公告)号：EP1974738A3

公开(公告)日：2008-12-17

申请号：EP08157330.5

申请日：2001-02-26

申请人： Alcon, Inc. ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Clark, Abbot F. ,  Fingert, John ,  McNatt, Loretta ,  Stone, Edwin M. ,  Wang, Wan-Heng

IPC分类号： C12Q1/68 ,  A61K38/00 ,  A61K31/70 ,  A61K39/395 ,  A01K67/027 ,  C12N15/00 ,  A61P27/06 ,  C12N9/00 ,  C07K14/47

CPC分类号： G01N33/5091 ,  A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12Q1/485 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/168

摘要： This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).

公开(公告)号：EP1974738A2

公开(公告)日：2008-10-01

申请号：EP08157330.5

申请日：2001-02-26

申请人： Alcon, Inc. ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Clark, Abbot F. ,  Fingert, John ,  McNatt, Loretta ,  Stone, Edwin M. ,  Wang, Wan-Heng

IPC分类号： A61K38/00 ,  A61K39/395 ,  A01K67/027 ,  C12N15/00 ,  A61P27/06 ,  C12N9/00 ,  C07K14/47 ,  C12Q1/68

CPC分类号： G01N33/5091 ,  A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12Q1/485 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/168

摘要： This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).

摘要翻译： 本发明提供了用于诊断和治疗青光眼的方法和组合物，所述方法和组合物基于确定无翅（Wnt）信号通路的组分的卷曲相关蛋白（FRP）的水平。 该方法可以包括用于诊断青光眼的遗传病变如多态等位基因（例如FRP启动子，...）的检测。 本发明还公开了使用转基因动物研究青光眼（筛选治疗学，动物疾病模型，...）。

公开(公告)号：EP1834645A1

公开(公告)日：2007-09-19

申请号：EP06010040.1

申请日：1999-07-29

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Cronan, John E., Jr. ,  Plapp, Bryce V. ,  Greenberg, E. Peter ,  Parsek, Matthew R.

IPC分类号： A61K31/70 ,  C12N9/00 ,  C12P21/02 ,  G01N33/68 ,  C07H19/20 ,  C07H19/167

CPC分类号： A61K31/7076 ,  C07H19/16 ,  C07H19/207 ,  C12Q1/25 ,  Y02A50/473

摘要： Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifying modulators of the autoinducers synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

摘要翻译： 提供了可用于调节自动抑制合成酶催化剂的活性的组合物和方法。 还提供了用于鉴定自动诱导剂合成反应的调节剂的方法。 这种调节剂可用于控制细菌生长，并且可用于特别是在免疫受损受试者中的细菌感染的治疗性治疗。 它们也可用于治疗与自身诱导剂合成和生物膜发育相关的疾病状态。

公开(公告)号：EP1804064A1

公开(公告)日：2007-07-04

申请号：EP06019641.7

申请日：2000-02-22

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Hageman, Gregory S.

IPC分类号： G01N33/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/78 ,  G01N2800/164 ,  G01N2800/329

摘要： The invention relates to diagnostics and therapeutics and animal models for macular degeneration, specifically as they relate to the association described herein between macular degeneration and arterial wall disruptive disorders. In one embodiment, the invention provides kits and methods for diagnosing macular degeneration comprising identifying a marker for an arterial wall disruptive disorder, including an aneurysm. In one embodiment, the invention provides therapeutics for treating macular degeneration comprising delivering to a subject an agent useful for treating an arterial wall disruptive disorder, including an aneurysm.

摘要翻译： 本发明涉及用于黄斑变性的诊断和治疗学和动物模型，具体地说，它们涉及本文描述的黄斑变性与动脉壁破坏性疾病之间的关联。 在一个实施方案中，本发明提供用于诊断黄斑变性的试剂盒和方法，其包括鉴定包括动脉瘤的动脉壁破坏性病症的标志物。 在一个实施方案中，本发明提供治疗黄斑变性的治疗剂，其包括将可用于治疗动脉壁破坏性疾病（包括动脉瘤）的药物递送至受试者。

公开(公告)号：EP1067956B1

公开(公告)日：2007-03-14

申请号：EP99916332.2

申请日：1999-04-02

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： KRIEG, Arthur M., University of Iowa ,  WEINER, George University of Iowa

IPC分类号： A61K38/19 ,  A61K31/70

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/55538 ,  A61K2039/55561 ,  A61K2300/00

摘要： The present invention relates to synergistic combinations of immunostimulatory CpG oligonucleotides and immunopotentiating cytokines. In particular, the invention relates to methods of stimulating an immune response using the synergistic combination of compounds and products related thereto.

公开(公告)号：EP1756288A2

公开(公告)日：2007-02-28

申请号：EP05778984.4

申请日：2005-05-02

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： ENGELHARDT, John, F. ,  YAN, Ziying

IPC分类号： C12N15/861

CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0008 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2810/60

摘要： The invention provides recombinant AAV vectors, at least one of which has heterologous terminal palindromic sequences, and methods of using those vectors.

公开(公告)号：EP1749534A2

公开(公告)日：2007-02-07

申请号：EP06021312.1

申请日：1998-12-11

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Weinstock, Joel ,  Elliott, David E.

IPC分类号： A61K35/56 ,  A61K35/62 ,  C12N5/06

CPC分类号： A61K35/62 ,  Y10S530/855

摘要： The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to reduce the excessive immune response in an individual. This invention is generally directed to autoimmune diseases which involve an excessive immune response or an aberrant/enhanced Th1 response. More specifically, the present invention is directed to the treatment of Crohn's disease and ulcerative colitis, both known as IBD. While the present invention discloses specific information about the treatment of IBD, the disclosure is in no way limiting. Additionally, rheumatoid arthritis, type 1 diabetes mellitus, lupus erythematosis, sarcoidosis and multiple sclerosis can be treated by the methods and compositions disclosed therein.

摘要翻译： 本发明涉及治疗对包含由在数量上足以减少在个体中过度免疫应答在施用蠕虫寄生虫制品异常/增强Th1反应过度的免疫应答的方法。 本发明涉及自身免疫性疾病在哪个过度免疫反应或异常/增强Th1反应涉及基因的反弹。 更具体地，本发明涉及克罗恩氏病和溃疡性结肠炎的治疗，这两个被称为IBD。 虽然关于IBD的治疗中本发明的盘少的特定信息，所述公开以任何方式限制。 此外，类风湿性关节炎，1型糖尿病，红斑狼疮，结节病和多发性硬化可以通过在其中游离缺失的方法和组合物盘进行处理。

公开(公告)号：EP0948510B1

公开(公告)日：2006-07-12

申请号：EP97947311.3

申请日：1997-10-30

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services,

发明人： KRIEG, Arthur, M. ,  KLINE, Joel, N. ,  Klinman, Dennis ,  Steinberg, Alfred D. ,  WEINER, George

IPC分类号： C12N15/11 ,  A61K39/39 ,  A61K31/70 ,  C07H21/04 ,  A61K45/00

CPC分类号： A61K39/00 ,  A61K31/00 ,  A61K31/4706 ,  A61K31/7048 ,  A61K31/711 ,  A61K31/7125 ,  A61K39/39 ,  A61K2039/55561 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12Q1/68 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/466 ,  Y02A50/54

摘要： Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.