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    Toxoid of dermonecrotic toxin produced by bordetella
    115.
    发明公开
    Toxoid of dermonecrotic toxin produced by bordetella 失效
    Kombinationsvakzine enthaltend Toxoid des dermonecrotischen Toxins von Bordetella bronchiseptica

    公开(公告)号：EP1297845A2

    公开(公告)日：2003-04-02

    申请号：EP02028045.9

    申请日：1995-06-07

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

    发明人： Kawai, Toru ,  Takase, Koso ,  Ushijima,Toshihiro ,  Fujikawa, Hideo

    IPC分类号： A61K39/10 ,  A61K39/102

    CPC分类号： C07K14/285 ,  A61K39/00 ,  C07K14/235

    摘要： The present invention aims at providing an improved toxoid of dermonecrotic toxin produced by Bordetella and a toxoid mixture comprising said improved toxoid of dermonecrotic toxin produced by Bordetella and a toxoid of dermonecrotic toxin produced by Pasteurella .
    Described is a method for partially purifying dermonecrotic toxin which comprises bringing a dermonecrotic toxin-containing solution into contact with a chromatographic gel sulfated by direct sulfation or a chromatographic gel to which a sulfated molecule is covalently bonded to thereby make the dermonecrotic toxin adsorbed on the gel, and eluting the adsorbed dermonecrotic toxin from the gel. There is provided a toxoid obtained from dermonecrotic toxin produced by Bordetella , said dermonecrotic toxin being prepared by the above method for partially purifying dermonecrotic toxin, and a toxoid mixture prepared by mixing said toxoid and a toxoid of dermonecrotic toxin produced by toxigenic Pasteurella , said toxoid mixture being safe and effective for preventing the atrophic rhinitis in pigs.

    摘要翻译： 本发明旨在提供由博德特氏菌产生的改良的皮肤坏死毒素类毒素和由博德特氏菌产生的所述改良的皮肤坏死毒素类毒素和由巴斯德氏菌产生的皮肤坏死毒素类毒素的类毒素混合物。 描述了一种用于部分纯化皮肤坏死毒素的方法，其包括使含有皮肤坏死毒素的溶液与通过直接硫酸化硫酸化的色谱凝胶接触或者与硫酸化分子共价键合的色谱凝胶接触，从而使皮肤坏死毒素吸附在凝胶上 并从凝胶中洗脱吸附的皮肤坏死毒素。 提供了由博德特氏菌产生的皮肤坏死毒素获得的类毒素，所述皮肤坏死毒素通过上述部分纯化皮肤坏死毒素的方法制备，并通过混合所述类毒素和由产毒巴斯德氏菌产生的皮肤坏死毒素类毒素制备的类毒素混合物，所述类毒素 混合物安全有效地预防猪萎缩性鼻炎。

    Cat-mouse chimeric antibody directed to feline diseases and corresponding heterohydridoma
    118.
    发明公开
    Cat-mouse chimeric antibody directed to feline diseases and corresponding heterohydridoma 失效
    Gegen Katze-Krankheite chimaerischer Katze-Maus-Antikörper和杂交杂交瘤

    公开(公告)号：EP1156064A2

    公开(公告)日：2001-11-21

    申请号：EP01118802.6

    申请日：1990-08-10

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Maeda, Hiroaki ,  Eda, Yasuyuki ,  Kimachi, Kazuhiko ,  Ono, Yoichi, Shinki Appartment 101 ,  Tokiyoshi, Sachio

    IPC分类号： C07K16/46 ,  C12N15/13 ,  C12N5/20 ,  G01N33/50

    CPC分类号： C12N5/166 ,  C07K16/00 ,  C07K16/081 ,  C07K16/462 ,  C07K2317/24 ,  C07K2319/00

    摘要： The application discloses a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin λ chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin κ chain; a gene fragment which comprises a DNA sequence coding for the constant region of feline immunoglobulin γ chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3' site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene.

    摘要翻译： 该申请公开了一种基因片段，其包含编码猫免疫球蛋白λ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白κ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白γ链恒定区的DNA序列; 编码小鼠-cat嵌合抗体的氨基酸序列的重组DNA分子，其包含编码小鼠免疫球蛋白的可变区的氨基酸序列的基因片段和编码恒定区的氨基酸序列的基因片段 的猫免疫球蛋白，其中后一个基因片段连接到前一个基因片段的3'位点; 一种小鼠-cat嵌合抗体的多肽，其由转化有细胞表达载体的细胞表达，其中所述重组DNA分子编码小鼠-cat嵌合抗体的氨基酸序列; 产生猫免疫球蛋白的猫 - 鼠异种杂交瘤; 以及制备猫免疫球蛋白基因的方法。

    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY
    119.
    发明公开
    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY 有权
    PEPTIDFRAGMENTE MIT DEN ZELLTOD VERHINDERNDERAKTIVITÄT

    公开(公告)号：EP1132402A1

    公开(公告)日：2001-09-12

    申请号：EP99972642.5

    申请日：1999-11-12

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

    发明人： HIRASHIMA, Masaki ,  MAEDA, Hiroaki ,  NOZAKI, Chikateru

    IPC分类号： C07K14/47 ,  A61K38/17 ,  C12N5/06 ,  C07K16/18

    CPC分类号： C07K14/4747 ,  A61K38/00

    摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.

    摘要翻译： 本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有由硒蛋白P的C末端上的103个氨基酸残基组成的氨基酸序列，或具有所述氨基酸序列与一个或多个 其中缺少，取代或添加的几个氨基酸残基或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列 的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。 本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。

    NOVEL PREVENTIVES/REMEDIES FOR IMMUNOPATHY
    120.
    发明公开
    NOVEL PREVENTIVES/REMEDIES FOR IMMUNOPATHY 审中-公开
    NEUE VORBEUGUNGSMEDIZIN / HEILMITTELFÜRIMMUNOPATHIEN

    公开(公告)号：EP1055429A1

    公开(公告)日：2000-11-29

    申请号：EP99902905.1

    申请日：1999-02-15

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute ,  KOWA COMPANY LTD.

    发明人： SASAKI, Takumi ,  KIMACHI, Kazuhiko ,  SOEJIMA, Kenji ,  KIMURA, Yumi ,  NOZAKI, Chikateru ,  FUJIYAMA, Yoshihide

    IPC分类号： A61K39/09 ,  A61K38/16

    CPC分类号： C07K14/31 ,  A61K38/164 ,  A61K39/085

    摘要： A prophylactic/remedy for immunopathy for immunopathy comprising, as an active ingredient, modifications of Staphylococcal enterotoxin B (SEB) with substitution of at least one amino acid residues within the amino acid sequence of natural type SEB, or derivatives thereof, wherein said SEB modifications or derivatives thereof have inhibitory activity on T cell activation wherein they interact with specific Vβ component of T cell receptor (TCR) but are reduced in their immunological responsiveness to SEB without inducing elimination of T cells having specific Vβ component, the elimination being normally induced by natural type SEB or recombinant wild-type SEB.

    摘要翻译： 作为免疫疾病免疫病的预防/治疗方法，其包含用天然型SEB的氨基酸序列中的至少一个氨基酸残基取代的葡萄球菌肠毒素B（SEB）或其衍生物作为活性成分的修饰，其中所述SEB修饰 或其衍生物对T细胞活化具有抑制活性，其中它们与T细胞受体（TCR）的特异性Vβ组分相互作用，但其对SEB的免疫应答降低，而不诱导具有特异性Vβ组分的T细胞的消除，消除正常 由天然型SEB或重组野生型SEB诱导。