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11 条记录 (耗时 0.013 秒)

    Cat-mouse heterohybridoma and gene fragment coding for constant region of feline immunoglobulin
    2.
    发明公开
    Cat-mouse heterohybridoma and gene fragment coding for constant region of feline immunoglobulin 失效
    Katze-Maus-Heterohybridoma und Genfragment，dasfürdie Konstant-Region von Katze-Immunoglobulin codiert。

    公开(公告)号：EP0417486A1

    公开(公告)日：1991-03-20

    申请号：EP90115426.0

    申请日：1990-08-10

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Maeda, Hiroaki ,  Eda, Yasuyuki ,  Kimachi, Kazuhiko ,  Ono, Yoichi ,  Tokiyoshi, Sachio

    IPC分类号： C07K13/00 ,  C12N15/13 ,  C12N5/20 ,  C12P21/08

    CPC分类号： C12N5/166 ,  C07K16/00 ,  C07K16/081 ,  C07K16/462 ,  C07K2317/24 ,  C07K2319/00

    摘要： The application discloses a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin λ chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin κ chain; a gene fragment which comprises a DNA sequence coding for the constant region of feline immunoglobulin γ chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3′ site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-­mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene.

    摘要翻译： 该申请公开了一种基因片段，其包含编码猫免疫球蛋白λ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白κ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白γ链恒定区的DNA序列; 编码小鼠-cat嵌合抗体的氨基酸序列的重组DNA分子，其包含编码小鼠免疫球蛋白的可变区的氨基酸序列的基因片段和编码恒定区的氨基酸序列的基因片段 的猫免疫球蛋白，其中后一个基因片段连接到前一个基因片段的3分钟位点; 一种小鼠-cat嵌合抗体的多肽，其由转化有细胞表达载体的细胞表达，其中所述重组DNA分子编码小鼠-cat嵌合抗体的氨基酸序列; 产生猫免疫球蛋白的猫 - 鼠异种杂交瘤; 以及制备猫免疫球蛋白基因的方法。

    Cat-mouse chimeric antibody directed to feline diseases and corresponding heterohydridoma
    3.
    发明公开
    Cat-mouse chimeric antibody directed to feline diseases and corresponding heterohydridoma 失效
    Gegen Katze-Krankheite chimaerischer Katze-Maus-Antikörper和杂交杂交瘤

    公开(公告)号：EP1156064A2

    公开(公告)日：2001-11-21

    申请号：EP01118802.6

    申请日：1990-08-10

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Maeda, Hiroaki ,  Eda, Yasuyuki ,  Kimachi, Kazuhiko ,  Ono, Yoichi, Shinki Appartment 101 ,  Tokiyoshi, Sachio

    IPC分类号： C07K16/46 ,  C12N15/13 ,  C12N5/20 ,  G01N33/50

    CPC分类号： C12N5/166 ,  C07K16/00 ,  C07K16/081 ,  C07K16/462 ,  C07K2317/24 ,  C07K2319/00

    摘要： The application discloses a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin λ chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin κ chain; a gene fragment which comprises a DNA sequence coding for the constant region of feline immunoglobulin γ chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3' site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene.

    摘要翻译： 该申请公开了一种基因片段，其包含编码猫免疫球蛋白λ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白κ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白γ链恒定区的DNA序列; 编码小鼠-cat嵌合抗体的氨基酸序列的重组DNA分子，其包含编码小鼠免疫球蛋白的可变区的氨基酸序列的基因片段和编码恒定区的氨基酸序列的基因片段 的猫免疫球蛋白，其中后一个基因片段连接到前一个基因片段的3'位点; 一种小鼠-cat嵌合抗体的多肽，其由转化有细胞表达载体的细胞表达，其中所述重组DNA分子编码小鼠-cat嵌合抗体的氨基酸序列; 产生猫免疫球蛋白的猫 - 鼠异种杂交瘤; 以及制备猫免疫球蛋白基因的方法。

    Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation
    5.
    发明公开
    Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation 失效
    编码由这些嵌合抗-HIV抗体和它们的制备方法表示的抗HIV抗体的可变区基因片段。

    公开(公告)号：EP0327000A2

    公开(公告)日：1989-08-09

    申请号：EP89101583.6

    申请日：1989-01-30

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Maeda, Hiroaki ,  Eda, Yasuyuki ,  Kimachi, Kazuhiko ,  Tokiyoshi, Sachio ,  Matsushita, Shuzo ,  Hattori, Toshio ,  Takatsuki, Kiyoshi

    IPC分类号： C12N15/13 ,  A61K39/395 ,  C12N5/10 ,  C12P21/08

    CPC分类号： C07K16/1063 ,  A61K38/00 ,  C07K2317/24

    摘要： Described are novel chimeric anti-human immunodeficiency virus (HIV) antibodies which comprise a constant region derived from human antibody and variable region derived from mouse monoclonal antibody, gene fragments coding for the variable region the H and L chain of chimeric anti-HIV antibodies which are effective for expression of chimeric anti-HIV antibodies having an HIV-neutralizing activity, a transformant where such gene fragments are incorporated, chimeric anti-HIV antibodies expressed therefrom and a process for their preparation. The chimeric anti-HIV antibodies of the present invention show anti-HIV neutralizing activity and are useful for the diagnosis, treatment and prevention of acquired immunodeficiency syndrome (AIDS) caused by HIV without side effects such as anaphylactic shock or serum sickness.

    摘要翻译： 描述的是新颖的，其包括来自人抗体和小鼠单克隆抗体的可变区的恒定区的嵌合抗 - 人免疫缺陷病毒（HIV）抗体，基因片段编码嵌合抗-HIV抗体的H和L链的可变区，其 有效用于具有HIV中和活性，其中一个检查基因片段掺入转化体，从那里过表达嵌合抗HIV抗体和用于制备它们的方法的嵌合抗-HIV抗体的表达。 本发明显示抗HIV中和活性的和嵌合的抗HIV抗体可用于无副作用由HIV引起的诊断，治疗和预防获得性免疫缺陷综合症的（AIDS）有用：如过敏性休克或血清病。

    Anti-feline calicivirus recombinant antibody and gene fragment encoding the same
    8.
    发明公开
    Anti-feline calicivirus recombinant antibody and gene fragment encoding the same 失效
    抗Felincalicivirus rekombinanterAntikörperunddafürkodierendes Gen。

    公开(公告)号：EP0561194A2

    公开(公告)日：1993-09-22

    申请号：EP93103066.2

    申请日：1993-02-26

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Kimachi, Kazuhiko ,  Maeda, Hiroaki ,  Nishiyama, Kiyoto ,  Tokiyoshi, Sachio ,  Tohya, Yukinobu, c/o Agriculture Department ,  Mikami, Takeshi

    IPC分类号： C12N15/13 ,  C12P21/08 ,  C07K13/00 ,  A61K39/125 ,  C12N15/62

    CPC分类号： C07K16/1045 ,  A61K38/00

    摘要： Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line lD7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.

    摘要翻译： 提供了有效治疗，预防和诊断FCV感染的抗FCV（猫杯状病毒）猫科型重组抗体和用于制备所述抗体的基因片段。 构建能够产生具有优异的FCV中和活性的小鼠单克隆抗体的细胞系1D7，获得编码负责所述抗体的FCV特异性结合的V区的基因片段。 该基因片段和编码猫抗体恒定区的基因用于产生嵌合抗FCV重组抗体。 获得的重组抗体是一种新的抗体，可用于诊断，治疗和预防猫病毒感染，特别是猫杯状病毒感染，对猫的施用具有高度的安全性。