公开(公告)号：EP0939655B1

公开(公告)日：2002-06-12

申请号：EP97910959.2

申请日：1997-10-15

申请人： ALZA CORPORATION

发明人： KNEPP, Victoria, Marie ,  PRESTRELSKI, Steven, J. ,  SMITH, Jessica, G. ,  HUANG, Manley, T., F.

IPC分类号： A61K47/06 ,  A61K9/10 ,  A61K38/48 ,  A61K38/17 ,  A61K48/00 ,  A61P7/02

CPC分类号： A61K9/0019 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/0026 ,  A61K9/10 ,  A61K38/212 ,  A61K38/38 ,  A61K38/4826 ,  A61K38/4846 ,  A61K47/06 ,  A61K48/00

公开(公告)号：EP1183010A2

公开(公告)日：2002-03-06

申请号：EP00939558.3

申请日：2000-05-31

申请人： ALZA Corporation

发明人： BRODBECK, Kevin, J. ,  PRESTRELSKI, Steven, J. ,  PUSHPALA, Shamim, J.

IPC分类号： A61K9/06 ,  A61K9/22 ,  A61K47/34

CPC分类号： A61K9/0024 ,  A61K9/1617 ,  A61K47/34

摘要： Methods and compositions for reducing the burst of beneficial agent from implantable systems is described. Such systems utilize compressed particulates of a beneficial agent, optionally mixed with a dissolution rate modulator or an agent exhibiting a characteristic of low solubility in water, such as a mixture of stearic acid and palmitic acid, dispersed throughout a bioerodible and biocompatible carrier.

公开(公告)号：EP1140012A2

公开(公告)日：2001-10-10

申请号：EP99966463.4

申请日：1999-12-10

申请人： Alza Corporation

发明人： DONG, Liang, C. ,  WAN, Jason ,  WONG, Patrick, S.,-L.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, and expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.

公开(公告)号：EP1112060A1

公开(公告)日：2001-07-04

申请号：EP99944089.4

申请日：1999-09-03

申请人： ALZA Corporation

发明人： DONG, Liang, C. ,  WONG, Patrick, S.- L. ,  ESPINAL, Steven, D.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.

公开(公告)号：EP0936893B1

公开(公告)日：2001-06-20

申请号：EP97912756.0

申请日：1997-10-14

申请人： ALZA Corporation

发明人： ROTH, Nathan ,  WONG, Patrick, S.-L. ,  FERRARI, Vincent, J.

IPC分类号： A61J7/00 ,  A47G21/18

CPC分类号： A61J7/0038 ,  A47G21/183 ,  A61K9/0004

摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member (10) having first and second ends (12, 14) comprises first (16) and second (26, 28, 30, 32) flow paths. Either of both of said flow paths contains an active agent (18). Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.

公开(公告)号：EP1083879A1

公开(公告)日：2001-03-21

申请号：EP99955212.8

申请日：1999-05-27

申请人： ALZA CORPORATION

发明人： AYER, Atul, D. ,  CHRISTOPHER, Carol, A. ,  GUINTA, Diane, R. ,  GUPTA, Suneel, K. ,  HAMEL, Lawrence, G. ,  HATAMKHANY, Zahedeh ,  LAM, Andrew, C. ,  SAKS, Samuel, R. ,  SHIVANAND, Padmaja ,  WEYERS, Richard, G. ,  WRIGHT, Jeri, D.

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K31/21

CPC分类号： A61K31/4402 ,  A61K9/0004 ,  A61K31/137 ,  A61K31/421 ,  A61K31/4422 ,  A61K31/4458 ,  G01N21/9508

摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

公开(公告)号：EP1077680A1

公开(公告)日：2001-02-28

申请号：EP99920262.5

申请日：1999-05-03

申请人： ALZA Corporation

发明人： EDGREN, David, E. ,  WONG, Patrick, S.-L. ,  JAO, Francisco ,  PUGA, Yolanda, M.

IPC分类号： A61K9/20

CPC分类号： A61K9/2072 ,  A61K9/2095 ,  A61K9/2893

摘要： The present invention is directed to an active agent dosage form and methods of its fabrication which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface one or more insoluble bands located in complementary grooves. The invention is also directed to articles of manufacture, methods and systems for fabricating the active agent dosage form.

公开(公告)号：EP1066081A1

公开(公告)日：2001-01-10

申请号：EP97946628.1

申请日：1997-11-07

申请人： ALZA CORPORATION

发明人： DIONNE, Keith, E. ,  LAUTENBACH, Scott, D. ,  EFTIMIE, Antoaneta, C. ,  LY, Kevin, S.

IPC分类号： A61M31/00

CPC分类号： A61K9/0004

摘要： The present invention relates to an osmotically driven agent delivery system for delivering a beneficial agent. The osmotic delivery system includes an osmotic agent which operates by imbibing fluid from an outside environment, causing the release of a beneficial agent. The osmotic delivery system includes a liquid or gel additive surrounding the osmotic agent for enhancing start-up and lubricating the osmotic agent. The liquid or gel additive is an incompressible lubricating fluid which fills any air gaps between the osmotic agent and the walls of a chamber and substantially reduces start-up delays.

公开(公告)号：EP1025845A3

公开(公告)日：2000-12-13

申请号：EP99204122.8

申请日：1995-06-23

申请人： ALZA CORPORATION

发明人： Merrill, Sonya ,  Ayer, Atul D. ,  Chadha, Navjot ,  Kuczynski, Anthony L.

IPC分类号： A61K31/485 ,  A61K9/00 ,  A61K9/20

CPC分类号： A61K9/2027 ,  A61K9/0004 ,  A61K9/2031 ,  A61K9/2054 ,  A61K31/485

摘要： An oral hydromorphone composition for the management of pain comprising dosage form providing analgesia via the oral route over an extended period of time, comprising a therapeutic composition comprising 1 to 1000mg of hydromorphone; 25 to 500mg of carboxymethylcellulose of 10,000 to 300,000 mw as a polymeric carrier; a binder agent selected from at least one of the 1 to 50mg of poly (vinyl) pyrrolidone of 10,000 to 300,000 mw or 1 to 50mg of hydroxypropylcellulose or hydroxypropylalkylcellulose of 7,500 to 75,000 mw; and 0 to 10 mg of a lubricant.

公开(公告)号：EP1057478A2

公开(公告)日：2000-12-06

申请号：EP00201378.7

申请日：1995-10-20

申请人： ALZA CORPORATION

发明人： Dong, Liang C. ,  Pollock, Crystal ,  Wong, Patrick S.-L. ,  Ferrari, Vincent Joseph

IPC分类号： A61K9/00 ,  C08L71/02 ,  C08L67/04 ,  C08J5/22

CPC分类号： C08L67/04 ,  A61K9/0004 ,  A61K9/2095 ,  A61K47/34 ,  A61K47/38 ,  B01D71/48 ,  C08L1/284 ,  C08L71/02 ,  C08L2666/26 ,  C08L2666/02 ,  C08L71/00 ,  C08L2666/18

摘要： The invention relates to a membrane, which can be injection moulded, comprising polycaprolactone and at least one of a poly (alkylene oxide), poly (ethylene glycol) or poly (hydroxypropylcellulose).