公开(公告)号：EP2128257A3

公开(公告)日：2010-03-03

申请号：EP09167384.8

申请日：1999-11-18

申请人： Aventis Pharma S.A. ,  INSERM (Institut National de la Santé et de la Recherche Medicale)

发明人： Brice, Alexis ,  Lucking, Christophe ,  Abbas, Nacer, Eddine ,  Denefle, Patrice ,  Ricard, Sylvain ,  Bouley, Sandrine

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  A61K38/17 ,  A61K39/395 ,  A61P25/16 ,  A01K67/027

CPC分类号： C12Q1/6883 ,  C07K16/40 ,  C12N9/104 ,  C12N9/93 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Y603/02019

摘要： La présente invention concerne des acides nucléiques codant pour des formes de la parkine humaine mutées, tronquées ou comportant des multiplications d'exons, et les protéines et anticorps correspondants. Elle concerne aussi des méthodes et kits pour l'identification de mutations du gène de la parkine, ainsi que pour l'étude de composés à visée thérapeutique.

公开(公告)号：EP1807697B1

公开(公告)日：2009-10-21

申请号：EP05812049.4

申请日：2005-10-24

申请人： Aventis Pharma S.A.

发明人： FOURNIER, Alain ,  BEHRENS, Ralf ,  BANDIERA, Silvio

IPC分类号： G01N33/53 ,  C12N15/65 ,  C12N15/81 ,  C12Q1/68

CPC分类号： C12N15/1055

摘要： The invention relates to a novel double hybrid system and to the uses thereof. This system provides, in particular, a tool that enables the detection of the interruption of a protein-protein interaction. The developed system uses transcription interference as a mechanism for detecting a breaking up of interacting protein pairs. The developed double hybrid system can be applied to the screening of molecules enabling the detection of molecules breaking up a protein-protein interaction as well as enabling the identification of alleles lacking in the interaction of proteins involved in the protein-protein interactions.

公开(公告)号：EP1779118B1

公开(公告)日：2009-02-25

申请号：EP05764126.8

申请日：2005-06-24

申请人： Aventis Pharmaceuticals Inc.

发明人： CAO, Yang ,  AYERS, Stephen ,  SABOL, Jeffrey, S.

IPC分类号： G01N33/88

CPC分类号： C12Q1/26 ,  G01N33/502 ,  G01N33/88 ,  G01N2333/99 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2500/10

公开(公告)号：EP2007769A1

公开(公告)日：2008-12-31

申请号：EP07731259.3

申请日：2007-04-06

申请人： Sanofi-Aventis

发明人： COMMERCON, Alain ,  ZHANG, Jidong ,  HITTINGER, Augustin

IPC分类号： C07D493/22 ,  A61K31/357 ,  A61P35/00

CPC分类号： C07D313/04 ,  C07D321/04 ,  C07D323/04 ,  C07D493/22

摘要： The present invention relates to novel dimers of specific artemisinin derivatives, to the preparation thereof, to compositions containing them, and to their use as a medicament, in particular as anticancer agents. (I).

公开(公告)号：EP1257642B1

公开(公告)日：2008-11-26

申请号：EP01907727.0

申请日：2001-02-07

申请人： Aventis Pharma S.A.

发明人： MAURY, Isabelle ,  MERCKEN, Luc ,  FOURNIER, Alain

IPC分类号： C12N15/12 ,  C07K14/47 ,  C12Q1/68 ,  C12N15/11 ,  A61K38/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The invention concerns novel compounds and their pharmaceutical, diagnostic use or as pharmacological target. More particularly, it concerns the identification of partners of FE65 and the use thereof, or any compound capable of modulating, at least partly, their interaction with FE65 to regulate FE65 activity, and in particular the phenomenon of intracellular transport or of APP endocytosis.

公开(公告)号：EP1556703B1

公开(公告)日：2008-10-22

申请号：EP03776874.4

申请日：2003-10-06

申请人： Aventis Pharma S.A.

发明人： MERCKEN, Luc ,  ZAMBRANO, Nicola ,  RUSSO, Tommaso

IPC分类号： G01N33/68

CPC分类号： C12Q1/485

摘要： The present invention relates to the identification of inhibitors of Src kinase, assays and methods useful for such identification and the use of Src inhibitors for the preparation of pharmaceuticals for the treatment of Alzheimer's disease.

公开(公告)号：EP0667912B1

公开(公告)日：2008-07-02

申请号：EP94922889.4

申请日：1994-07-08

申请人： CENTELION

发明人： PERRICAUDET, Michel ,  VIGNE, Emmanuelle ,  YEH, Patrice

IPC分类号： C12N15/861 ,  C12N5/10 ,  A61K48/00

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10323 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2710/10362 ,  C12N2830/002

摘要： Novel adenovirus-derived viral vectors, the preparation thereof, and the use thereof in gene therapy, are disclosed.

公开(公告)号：EP1914242A1

公开(公告)日：2008-04-23

申请号：EP06291628.3

申请日：2006-10-19

申请人： Sanofi-Aventis

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07K16/28 ,  C07K16/46

CPC分类号： G01N33/57426 ,  A61K47/6803 ,  A61K47/6867 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/462 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  G01N33/57484 ,  G01N2333/924

摘要： Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CDC38, are capable of killing CD38 + cells by apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and/or complement-dependent cytotoxicity (CDC). Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of CD38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic myelogenous leukemia, acute myelogenous leukemia, or acute lymphocytic leukemia, or the treatment of autimmune diseases such as systemic lupus, rheumatoid arthritis, multiple sclerosis, erythematosus, and asthma. Said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of CD38. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CD38 protein.

摘要翻译： 能够通过细胞凋亡，抗体依赖性细胞介导的细胞毒性（ADCC）杀死CD38 +细胞的抗体，人源化抗体，表面抗体，抗体片段，衍生抗体和与细胞毒性剂的缀合物，其特异性结合CDC38能够杀死CD38 +细胞， /或补体依赖性细胞毒性（CDC）。 所述抗体及其片段可用于治疗表达CD38蛋白水平升高的肿瘤，例如多发性骨髓瘤，慢性淋巴细胞性白血病，慢性骨髓性白血病，急性骨髓性白血病或急性淋巴细胞白血病，或治疗自身免疫性疾病 作为系统性红斑狼疮，类风湿性关节炎，多发性硬化，红斑和哮喘。 所述衍生化的抗体可以用于表达高水平的CD38的肿瘤的诊断和成像。 还提供了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，使用缀合物抑制细胞生长和治疗疾病的方法，以及包含细胞毒性缀合物的试剂盒。 特别地，细胞结合剂是识别并结合CD38蛋白的单克隆抗体及其表位结合片段。

公开(公告)号：EP1032695B1

公开(公告)日：2008-04-23

申请号：EP98955679.0

申请日：1998-11-17

申请人： CENTELION

发明人： CROUZET, Joël ,  ROBERT, Jean-Jacques ,  VIGNE, Emmanuelle ,  YEH, Patrice

IPC分类号： C12N15/86 ,  C12N5/10

CPC分类号： C12N15/86 ,  C12N2710/10343

摘要： The invention concerns a method for reducing recombination phenomena among nucleic acids. It also concerns the use of said method for producing defective viruses not contaminated by replication particles. The invention further concerns novel viral constructs.

公开(公告)号：EP1314040B1

公开(公告)日：2008-04-09

申请号：EP01963064.9

申请日：2001-08-07

申请人： Aventis Pharma S.A.

发明人： ITIER, Jean-Michel ,  MULTON, Marie-Christine ,  RET, Gwénaëlle ,  STUTZMANN, Jean-Marie ,  WAHL, Florence

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6872 ,  G01N33/6896 ,  G01N2333/4703 ,  G01N2500/04 ,  G01N2500/10

摘要： The invention concerns the use of whole or part of the GRF1 protein, or of cells expressing whole or part of the GRF1 protein, in methods for detecting compounds for preventing and/or treating pathologies or disorders of the central nervous system involving neuronal death, such as apoptosis, or related to leptin metabolism. The pathologies of the central nervous system are in particular cerebral ischemia, Parkinson's disease or Alzheimer's disease.