公开(公告)号：EP1221446B1

公开(公告)日：2005-04-06

申请号：EP02008065.1

申请日：1996-05-10

申请人： SANDOZ AG

发明人： Ascher, Gerd ,  Ludescher, Johannes

IPC分类号： C07D501/24 ,  A61K31/545 ,  A61P31/04

CPC分类号： C07D501/00

公开(公告)号：EP1504664A1

公开(公告)日：2005-02-09

申请号：EP03017131.8

申请日：2003-07-29

申请人： Novartis AG

发明人： Rakoczi, Ferenc Jozsef ,  Hug, Jean-Louis

IPC分类号： A01N25/10 ,  A01N43/34 ,  A01N43/88 ,  A01N43/38 ,  A01N43/56 ,  A01N47/42 ,  A01N47/22 ,  A01N53/00 ,  A01N25/12

CPC分类号： A01N25/006 ,  Y10S514/951 ,  Y10S514/974

摘要： The invention is directed at a ready-to-use granule bait composition, its preparation and use for the control of house flies inside houses and animal stalls, fodder stores and sanitary installations.

摘要翻译： 本发明涉及即用型颗粒诱饵组合物，其制备和用途，用于控制房屋和动物摊位，饲料商店和卫生设施内的家蝇。

公开(公告)号：EP1259502B1

公开(公告)日：2005-01-12

申请号：EP01920158.1

申请日：2001-02-28

申请人： HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC.

发明人： GUNASEKERA, Sarath, P. ,  LONGLEY, Ross, E. ,  ISBRUCKER, Richard A. ,  PAUL, Gopal K. ,  POMPONI, Shirley, A. ,  WRIGHT, Amy, E.

IPC分类号： C07D309/30 ,  A61K31/365 ,  A61P35/00 ,  C07C271/22 ,  C07D309/32

CPC分类号： C07D309/32 ,  A61K31/365 ,  C07B2200/07 ,  C07C271/22 ,  C07D309/30

摘要： The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents. The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.

公开(公告)号：EP1054994B1

公开(公告)日：2004-11-17

申请号：EP99911678.3

申请日：1999-02-17

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： HOFMANN, Hans ,  MAHNKE, Marion ,  MEMMERT, Klaus ,  PETERSEN, Frank ,  SCHUPP, Thomas ,  KÜSTERS, Ernst ,  MUTZ, Michael

IPC分类号： C12P17/18 ,  C07D493/04 ,  B01D15/08 ,  A61K31/335 ,  A61P35/00

CPC分类号： C07D493/04 ,  C07D417/14 ,  C07K2299/00 ,  C12P17/167 ,  C12P17/181 ,  C12R1/01

公开(公告)号：EP1230131B1

公开(公告)日：2004-06-30

申请号：EP00988722.5

申请日：2000-11-17

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： JUX, Egbert

IPC分类号： B65D75/34

CPC分类号： B65D75/327 ,  B65D75/326 ,  B65D2575/3245 ,  B65D2585/545 ,  Y10S206/82

摘要： The invention relates to a blister package for an optical lens and is concerned with the problem of improving the blister package in such a way that the base parts (B) can be stacked and the work involved in sorting can be substantially reduced. This is achieved by perfecting spacing elements (2, 3) and joining several base parts (B) to one unit (17).

摘要翻译： 本发明涉及一种用于光学透镜的泡罩包装，并且涉及改进泡罩包装的问题，使得底部部件（B）可以堆叠并且可以显着减少涉及分拣的工作。 这是通过完善间隔元件（2,3）并将几个基座部分（B）连接到一个单元（17）来实现的。

公开(公告)号：EP1230227B1

公开(公告)日：2004-06-23

申请号：EP00981270.2

申请日：2000-11-17

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BILLICH, Andreas ,  SCHREINER, Erwin, Paul ,  WOLFF-WINISKI, Barbara

IPC分类号： C07D263/56 ,  C07D277/64 ,  C07D413/06 ,  C07D417/06 ,  A61K31/423 ,  A61K31/428 ,  A61P17/00 ,  A61P35/00

CPC分类号： C07D263/56 ,  C07D263/57 ,  C07D277/64 ,  C07D413/06

公开(公告)号：EP1401468A2

公开(公告)日：2004-03-31

申请号：EP01986264.8

申请日：2001-10-05

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： LIAU, Gene ,  STEFANSSON, Steingrimur ,  SU, Joseph

IPC分类号： A61K38/00

CPC分类号： A61K38/45 ,  A61K48/00 ,  C12N9/1205 ,  C12N2799/021 ,  A61K2300/00

摘要： A method of inducing blood vessel formation in an animal by administering to the animal a polynucleotide encoding a sphingosine kinase, or an analogue, fragment, or derivative thereof. The polynucleotide may be contained in an appropriate expression vector, such as a viral vector. The delivery of sphingosine kinase through administration of an expression vector which expresses sphingosine kinase provides for the formation of larger blood vessels containing a well defined structure that is supported by mural cells such as pericytes and smooth muscle cells.

公开(公告)号：EP1364038A2

公开(公告)日：2003-11-26

申请号：EP01962700.9

申请日：2001-06-01

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： JAKUBCZAK, John, Leonard ,  ROLLENCE, Michele, Lynette ,  STEWART, David, A. ,  STEVENSON, Susan, C. ,  HALLENBECK, Paul, L. ,  IDAMKANTI, Neeaja ,  KALEKO, Michael ,  SMITH, Theodore

IPC分类号： C12N15/86 ,  C12N15/34 ,  C12N5/10 ,  C07K14/075 ,  C12N7/04

CPC分类号： C12N7/00 ,  A61K48/00 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/10222 ,  C12N2710/10243 ,  C12N2800/30 ,  C12N2810/405 ,  C12N2810/6018

摘要： This invention relates to mutated adenoviral fiber proteins and adenovirus particles containing such proteins. It further relates to polynucleotides encoding the proteins and vectors containing polynucleotides. It also relates to methods for making and using the adenoviral particles. With the mutated fiber proteins, the adenovirus particles no longer bind to their natural cellular receptor. They can then be 'retargeted' to a specific cell type through the addition of a ligand to the virus capsid, which causes the virus to bind to and infect such cell. Specific fiber mutations are listed, which ablate binding to the natural receptor. Adenovirus particles with certain fiber mutations were found to enhance gene transfer to and expression in liver as compared to viral particles with wild-type fiber.

公开(公告)号：EP1364017A2

公开(公告)日：2003-11-26

申请号：EP01980246.1

申请日：2001-08-16

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： JARAI, Gabor,Novartis Horsham Research Centre ,  YOUSEFI, Shida

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N15/11 ,  C07K16/28 ,  G01N33/50 ,  A61K39/395 ,  A61K38/17 ,  A61K31/7105

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/723 ,  C12N2799/026

摘要： A pharmaceutical composition comprising as active ingredient (A) a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:16 or a functionally equivalent variant of said amino acid sequence; or (B) a polynucleotide comprising a nucleotide sequence encoding the polypeptide (A); or (C) an antibody which is immunoreactive with the polypeptide (A); or (D) an antisense oligonucleotide comprising a nucleotide sequence complementary to that of polynucleotide (B); and the use of (A), (B), (C) and (D) in diagnostic and therapeutic applications.

公开(公告)号：EP1281400A3

公开(公告)日：2003-11-05

申请号：EP02023033.0

申请日：1996-07-12

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： Guitard, Patrice ,  Haeberlin, Barbara ,  Link, Rainer ,  Richter, Friedrich

IPC分类号： A61K31/445 ,  A61K9/14 ,  A61K47/48

CPC分类号： A61K31/4745 ,  A61K9/145 ,  A61K9/146 ,  A61K31/436 ,  A61K31/445 ,  Y10S514/885 ,  Y10S514/922 ,  Y10S514/95 ,  Y10S514/964 ,  Y10S514/97

摘要： A pharmaceutical composition for oral administration in the form of a solid dispersion comprising an ascomycin or a derivative thereof and a carrier medium.

摘要翻译： 以固体分散体形式用于口服给药的药物组合物，其包含子囊霉素或其衍生物和载体介质。