公开(公告)号：EP4082543A1

公开(公告)日：2022-11-02

申请号：EP20906105.0

申请日：2020-12-18

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： SHIMIZU Tatsuya ,  ESU Takako ,  NISHIMURA Shinpei

IPC分类号： A61K31/4174 ,  A61K9/70 ,  A61K47/18 ,  A61K47/36 ,  A61L31/16 ,  A61M37/00 ,  A61P25/20

摘要： The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.

公开(公告)号：EP3925606A1

公开(公告)日：2021-12-22

申请号：EP20755904.8

申请日：2020-01-23

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： KUROKAWA Takao ,  ARAKI Hiroyuki ,  KOMATANI Kimiko

IPC分类号： A61K31/381 ,  A61P25/14 ,  A61P25/16 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32

摘要： The present invention provides a rotigotine stabilization method for stabilizing rotigotine and/or a pharmaceutically acceptable salt thereof in a rotigotine-containing patch comprising a backing layer and an adhesive agent layer, the adhesive agent layer containing the rotigotine and/or the pharmaceutically acceptable salt thereof and a styrene-based thermoplastic elastomer, the method comprising further incorporating cross-linked polyvinylpyrrolidone in the adhesive agent layer in a content of 3 to 25% by mass in the adhesive agent layer.

公开(公告)号：EP3815737A1

公开(公告)日：2021-05-05

申请号：EP19824984.9

申请日：2019-06-20

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： HORI Ryota ,  NISHIMURA Shinpei

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61K31/4174 ,  A61K47/36

摘要： The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

公开(公告)号：EP3760198A1

公开(公告)日：2021-01-06

申请号：EP19761141.1

申请日：2019-02-19

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： NAKANISHI Toshihiro ,  NAGASE Yuko ,  MATSUMURA Shinya ,  KOSE Yasuhisa

IPC分类号： A61K31/196 ,  A61K9/10 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/34 ,  A61K47/38 ,  A61P29/00

摘要： The present invention provides an emulsified gel composition comprising diclofenac sodium, water, a gelling agent, an antioxidant, and a surfactant having an HLB of 14 or more, in which the gelling agent is a nonionic water-soluble polymer.

公开(公告)号：EP2764887B1

公开(公告)日：2020-12-02

申请号：EP12838997.0

申请日：2012-10-02

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： TOKUMOTO, Seiji ,  OGURA, Makoto

IPC分类号： A61M37/00

公开(公告)号：EP2457592B1

公开(公告)日：2020-09-16

申请号：EP10802225.2

申请日：2010-07-15

申请人： Hisamitsu Pharmaceutical Co., Inc. ,  Toppan Printing Co., Ltd.

发明人： TERAHARA, Takaaki ,  TOKUMOTO, Seiji ,  TAMURA, Akira ,  YAMADA, Yumiko

IPC分类号： A61M37/00 ,  A61B5/15 ,  A61K9/00 ,  A61K47/34

公开(公告)号：EP3006077B1

公开(公告)日：2020-05-27

申请号：EP14804072.8

申请日：2014-05-29

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： HASHIMOTO, Eiji ,  MATSUDO, Toshiyuki ,  NISHIMURA, Shinpei ,  TOKUMOTO, Seiji

IPC分类号： A61M37/00 ,  B81C1/00 ,  B05D3/04

公开(公告)号：EP3616698A1

公开(公告)日：2020-03-04

申请号：EP18790527.8

申请日：2018-04-19

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： KOMINAMI Kazuya ,  SHIMA Takito ,  UCHIDA Naoyuki ,  FUJITA Naoko ,  SUZUKI Shigeo ,  KAIHO Terumitsu

IPC分类号： A61K31/485 ,  A61K9/70 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61P25/04

摘要： A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

公开(公告)号：EP2957315B1

公开(公告)日：2019-11-13

申请号：EP14751051.5

申请日：2014-02-12

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： FUDOUJI, Ryusuke ,  OGURA, Makoto

IPC分类号： A61M37/00

公开(公告)号：EP3067088B1

公开(公告)日：2019-09-04

申请号：EP14859702.4

申请日：2014-11-04

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： ARAMI, Shunsuke ,  NISHIMURA, Shinpei ,  TOKUMOTO, Seiji ,  OGURA, Makoto

IPC分类号： A61M37/00