公开(公告)号：EP2110123A2

公开(公告)日：2009-10-21

申请号：EP09700092.1

申请日：2009-03-30

申请人： Shiseido Company, Ltd.

发明人： IINO, Masato ,  AMANO, Satoshi

IPC分类号： A61K8/99 ,  A61Q19/08 ,  A61K8/97

CPC分类号： A61Q19/08 ,  A61K8/97 ,  A61K8/99

摘要： It is intended to safely and effectively enhance growth of fibroblasts of skin. An agent for growing fibroblasts contains a yeast extract and a safflower extract as effective constituents.

摘要翻译： 旨在安全有效地增强皮肤成纤维细胞的生长。 生长成纤维细胞的药剂含有酵母提取物和红花提取物作为有效成分。

公开(公告)号：EP2082729A1

公开(公告)日：2009-07-29

申请号：EP07828673.9

申请日：2007-09-28

申请人： SHISEIDO COMPANY, LTD. ,  NOF Corporation

发明人： OHMORI, Takashi ,  ISHIKUBO, Akira ,  TESHIGAWARA, Takashi ,  SUGIYAMA, Yuki ,  YAGI, Eiichiro ,  MARUYAMA, Kei-ichi ,  TAGUCHI, Sue ,  TEZUKA, Yoji

IPC分类号： A61K8/86 ,  A61Q19/00 ,  A61Q19/10

CPC分类号： A61Q19/00 ,  A61K8/90 ,  A61Q1/14 ,  A61Q19/10

摘要： The present invention was made in view of the above-described circumstances, and an object of the invention is to provide an external skin preparation having a rough skin improving effect, excellent in texture in use, especially excellent in smoothness, free of sticky feeling, and excellent in stability. Another object is to provide a skin cleanser excellent especially in usability and a cosmetic removing effect.
That is, the external skin preparation of the present invention is characterized by comprising a block-type alkylene oxide derivative represented by the below-described formula (I).

        [formula 1] Y-[O(EO) a -(AO) b -(EO) o -R] k      (I)

(In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 6 carbon atoms, and they are attached in a block-type, respectively. The products, a×k, b×k, and c×k, are the average addition mole numbers of the oxyethylene group, the oxyalkylene group having 3 to 6 carbon atoms, and the oxyethylene group, respectively, and 0 ≦a×k≦ 100, 1≦b×k≦ 100, and 0≦c×k≦ 100, however, (a+c)×k>1. The percentage of all oxyethylene groups in formula (I) with respect to the sum of all oxyethylene groups and oxyalkylene groups having 3 to 6 carbon atoms in formula (I) is 10 to 80 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups with 1 to 4 carbon atoms.)
The skin cleanser of present invention is characterized by comprising 0.01 to 70 mass % of a block-type alkylene oxide derivative represented by the above-described formula (I) and 0.1 to 20 mass % of a moisturizer.

摘要翻译： 发明内容本发明是鉴于上述情况而完成的，其目的在于提供一种具有粗糙的皮肤改善效果，使用性质优异，平滑性优异，无粘性的外用皮肤剂， 稳定性好。 另一个目的是提供一种特别优异的可用性和美容消除效果的皮肤清洁剂。 也就是说，本发明的皮肤外用剂的特征在于含有下述式（I）表示的嵌段型烯化氧衍生物。 €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ （I）（式中，Y为通过从具有3〜6个羟基的多元醇除去羟基而得到的残基，k为多元醇的羟基数，EO为氧化乙烯基，AO 是具有3〜6个碳原子的氧化烯基，分别以嵌段型连接，a×k，b×k，c×k是氧化乙烯基的平均加成摩尔数， 分别为3〜6个碳原子的氧化烯基和氧乙烯基，0‰| a×k‰| 100，1‰| b×k‰| 100，0‰| c×k‰| 100 式（I）中所有氧亚乙基相对于式（I）中所有氧亚乙基和碳原子数为3〜6的氧化烯的总和的百分比为10〜80质量％ ％.Rs可以彼此相同或不同，它们是烃 具有1至4个碳原子的基团。）本发明的皮肤清洁剂的特征在于，含有0.01〜70质量％的上述式（I）表示的嵌段型烯化氧衍生物和0.1〜20质量％ 保湿。

公开(公告)号：EP2039419A1

公开(公告)日：2009-03-25

申请号：EP07743290.4

申请日：2007-05-14

申请人： SHISEIDO COMPANY, LTD.

发明人： MATSUSHITA, Yuji ,  OHMORI, Takashi ,  NODA, Akira

IPC分类号： B01F17/42 ,  A61K8/04 ,  A61K8/86 ,  A61Q19/10 ,  B01F17/52 ,  C11D1/722 ,  C11D3/37

CPC分类号： A61Q19/005 ,  A61K8/361 ,  A61K8/39 ,  A61K8/463 ,  A61K8/556 ,  A61K8/86 ,  A61Q19/10 ,  B01F17/0028 ,  B01F17/0057 ,  C11D1/06 ,  C11D1/29 ,  C11D1/345

摘要： The present invention is to provide a new surfactant that can be used as an emulsifier excellent in emulsion stability and texture in use and as a cleanser excellent in cleansing power and texture in use and having low skin irritation.
A surfactant consisting of a compound represented by the below-described general formula (1).

        Y-O-(EO) l -(AO) m -(EO) n -X     (1)

(In the formula, AO represents an oxyalkylene group having 3 to 4 carbon atoms; m is the average addition mole number of the oxyalkylene group and satisfies 5≦m≦100. EO represents an oxyethylene group; 1 and n are the average addition mole numbers of the oxyethylene groups and satisfy 0≦1≦4 and 0≦n≦4. Either X or Y or both are a functional group represented by -SO 3 M, -COOM, -HPO 3 M, -(CH 2 ) q -SO 3 M, or -(CH 2 ) q -COO, wherein M is a hydrogen ion or a monovalent inorganic or organic cation, and q is the number of carbon atoms of the linked alkylene group and satisfies 1≦q≦4. When either X or Y is the above-described functional group, the other one can be a hydrogen atom, a methyl group, or an ethyl group.)

摘要翻译： 本发明提供一种可用作乳液稳定性和使用质地优异的乳化剂的新型表面活性剂，作为清洁力和使用质地优异，皮肤刺激性低的清洁剂。 由下述通式（1）表示的化合物组成的表面活性剂。 €ƒ€ƒ€ƒ€ƒ€ƒ€ƒY-O-（EO）l - （AO）m - （EO）n -X€ƒ€ƒ€ƒ€ƒ（1）（In 式中，AO表示碳原子数3〜4的氧化烯基，m表示氧化烯基的平均加成摩尔数，满足5‰| m‰| 100，EO表示氧化乙烯基，1表示平均加成摩尔 氧乙烯基的数目满足0‰| 1‰|4和0‰| n‰|4。X或Y或两者均为-SO 3 M，-COOM，-HPO 3 M， - （ CH 2）q -SO 3 M或 - （CH 2）q -COO，其中M为氢离子或一价无机或有机阳离子，q为连接的亚烷基的碳原子数，满足1‰ | q‰|4。当X或Y为上述官能团时，另一个可以是氢原子，甲基或乙基。）

公开(公告)号：EP1977730A1

公开(公告)日：2008-10-08

申请号：EP06842872.1

申请日：2006-12-19

申请人： SHISEIDO COMPANY, LTD.

发明人： ARAKI, Hidefumi ,  ABE, Koji ,  YAJIMA, Isao ,  KAKOKI, Hiroyuki ,  OGUCHI, Nozomi

IPC分类号： A61K8/35 ,  A61K8/40 ,  A61K8/49 ,  A61Q17/04

CPC分类号： A61K8/496 ,  A61K2800/26 ,  A61Q17/04

摘要： The present invention is a sunscreen cosmetic comprising 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane, a benzotriazole derivative represented by the following general formula (I), and ethylhexyl 2-cyano-3,3-diphenylacrylate.
The present invention is a sunscreen cosmetic comprising hexyl diethylaminohydroxybenzoylbenzoate and a benzotriazole derivative represented by the following general formula (I).

(In this formula, R' = a straight chain alkyl group of C1-C6 and R" = a straight chain alkyl group of C1-C3.)
The object of the present invention is to provide a sunscreen cosmetic that prevents staining due to secondary adhesion to clothing.

摘要翻译： 本发明是包含4-（1,1-二甲基乙基）-4'-甲氧基二苯甲酰甲烷，由以下通式（I）表示的苯并三唑衍生物和2-氰基-3,3-二苯基丙烯酸乙基己酯的防晒化妆品。 本发明是一种包含二乙基氨基羟基苯甲酰基苯甲酸己酯和由以下通式（I）表示的苯并三唑衍生物的防晒化妆品。 （在该式中，R'= C1-C6的直链烷基，R“= C1-C3的直链烷基。）本发明的目的是提供防止二次染色的防晒化妆品 粘附到衣服。

公开(公告)号：EP1410782B1

公开(公告)日：2008-07-30

申请号：EP02738774.5

申请日：2002-06-20

申请人： SHISEIDO COMPANY, LTD.

发明人： OMURA, Takayuki, Shiseido Res.Ctr. (Shin-Yokohama) ,  SHIDA, Tomotaka, Shiseido Res.Ctr. (Shin-Yokohama) ,  NANBA, Tomiyuki, Shiseido Res.Ctr. (Shin-Yokohama)

IPC分类号： A61K8/87 ,  A61Q1/00 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q19/00

CPC分类号： A61Q19/00 ,  A61K8/0212 ,  A61K8/87 ,  A61K8/898 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q3/02 ,  A61Q5/00 ,  A61Q5/06 ,  A61Q17/04 ,  A61Q19/02

摘要： It is intended to develop a film agent made of a novel amphoteric urethane resin and apply to cosmetics, in particular, hair cosmetics and external preparations for the skin. Namely, cosmetics characterized by containing an amphoteric urethane resin carrying a polysiloxane compound. Thus excellent cosmetics which can fully exert the film properties of the novel polysiloxane−carrying amphoteric urethane resin can be obtained. In case of hair cosmetics, for example, a favorable elasticity of the hair and excellent brushing properties without causing flaking can be established. In case of skin cosmetics, a moist and smooth feel and an appropriate elasticity can be imparted to the skin.

公开(公告)号：EP1859806A1

公开(公告)日：2007-11-28

申请号：EP05787935.5

申请日：2005-09-22

申请人： SHISEIDO COMPANY, LTD.

发明人： HIBINO, Toshihiko,Shiseido Research Center ,  NAKANISHI, Jotaro,Shiseido Research Center ,  KATAGIRI, Chika,Shiseido Research Center

IPC分类号： A61K45/00

CPC分类号： C12Q1/37 ,  A61K31/713 ,  A61K36/185 ,  A61K36/42 ,  A61K36/725 ,  A61K36/81 ,  A61K36/87 ,  A61K36/88 ,  G01N33/5044 ,  G01N2500/04 ,  G01N2800/20 ,  G01N2800/205

摘要： In a first aspect thereof, the present invention provides a method for treatment and/or prevention of a disease selected from the group consisting of psoriasis and squamous cell carcinoma by inhibiting the expression of squamous cell carcinoma antigen (SCCA) by cells. In another aspect thereof, the present invention provides a method for screening for substances that inhibit epidermal parakeratosis, wherein the activity of a candidate substance that inhibits cysteine protease inhibitory activity possessed by squamous cell carcinoma antigen 1 (SCCA-1) is used as an indicator.

摘要翻译： 在其第一方面，本发明提供了选自牛皮癣和鳞状上皮细胞癌通过抑制鳞状上皮细胞癌抗原（SCCA）的由细胞中的表达的选择的疾病的治疗和/或预防的方法。 在其另一个方面，本发明提供了一种方法，用于筛选物质也抑制表皮角化不全，worin的候选物质的活性做了抑制由鳞状细胞癌抗原1（SCCA-1）被用作指示器具有的半胱氨酸蛋白酶抑制活性 ，

公开(公告)号：EP1839647A1

公开(公告)日：2007-10-03

申请号：EP05814307.4

申请日：2005-12-01

申请人： SHISEIDO COMPANY, LTD.

发明人： YOSHIDA, Mari, Shiseido Research Center ,  TAKAHASHI, Akiko, Shiseido Research Center ,  OKAMOTO, Tohru, Shiseido Research Center

IPC分类号： A61K8/92 ,  A61K8/89 ,  A61Q19/00

CPC分类号： A61K8/89 ,  A61K8/92 ,  A61Q19/00

摘要： An oil based composition for external use on skin for enhancing percutaneous absorption of a water-soluble agent contains 50% by mass to 95% by mass of an oil constituent, which contains 10% by mass to 100% by mass of a solid or semisolid oil constituent, and 5% by mass to 50% by mass of particles. The composition has occlusivity of at least 50% and is adapted for use such that, after a preparation for external use on skin, which preparation contains a water-soluble agent, has been applied onto skin, the composition may be applied onto the preparation for external use on skin, which preparation has been applied onto the skin. A method of enhancing percutaneous absorption of a water-soluble agent utilizes the composition.

摘要翻译： 用于皮肤外用于增强经皮吸收水溶性物质的油性组合物含有50质量％至95质量％的油成分，其含有10质量％至100质量％的固体或半固体 油成分，5质量％〜50质量％的颗粒。 该组合物具有至少50％的吸留性，并适于使用，使得在外用皮肤上制备含有水溶性剂的皮肤外用剂已经施用到皮肤上时，可以将组合物施用于 外用于皮肤，该制剂已经涂抹在皮肤上。 提高水溶性试剂的经皮吸收的方法利用该组合物。

公开(公告)号：EP0610511B2

公开(公告)日：2007-08-01

申请号：EP93914996.9

申请日：1993-07-13

申请人： SHISEIDO COMPANY, LTD.

发明人： YANAGIDA, Takeshi The Shiseido Research Center ,  SAKAMOTO, Okihiko The Shiseido Research Center

IPC分类号： A61K8/45 ,  A61K8/00 ,  A61K31/57 ,  A61K31/19 ,  A61K31/80 ,  A61K31/70 ,  A61K31/60 ,  A61K31/07 ,  A61K31/405 ,  A61K31/195 ,  A61K31/165

CPC分类号： A61Q19/00 ,  A61K8/0212 ,  A61K8/06 ,  A61K8/60 ,  A61K8/671 ,  A61K8/894 ,  A61K31/07 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/405 ,  A61K31/415 ,  A61K31/57 ,  A61K31/60 ,  A61K31/70 ,  A61K31/80 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/12 ,  A61K2300/00

摘要： A composition for dermatologic preparation comprising vitamin A and at least one chap ameliorant aid selected from the group consisting of polyoxyalkylene-modified organopolysiloxane, sugars and anti-inflammatory.

公开(公告)号：EP1741338A1

公开(公告)日：2007-01-10

申请号：EP05738964.5

申请日：2005-04-27

申请人： SHISEIDO COMPANY, LTD.

发明人： YOKOYAMA, Mineyuki, c/o SHISEIDO RESEARCH CENTER ,  TANAKA, Osamu ,  NAKAMURA, Kentaro, c/o SUMITOMO FORESTRY CO., LTD

IPC分类号： A01N37/42

CPC分类号： A01N37/42 ,  A01N2300/00 ,  A01N25/00 ,  A01N43/38

摘要： An inducing agent for plant root including a ketol unsaturated fatty acid having 5 to 24 carbon atoms, 1 to 6 double bonds between carbon atoms and an α ketol structure or γ ketol structure (in particular 9-hydroxy-10-oxo-12( Z ), 15( Z )-octadecadienoic acid is preferable), which inducing agent for plant root may be used to promote or induce the root growth even when transplanting by cutting plants for which root generation is hard such as pine, cedar, tea, chestnut, may be used even for root growth of cuttings of Prunus x yedoensis (cherry trees) for which root growth is considered impossible, Hypericum chinense for which is transplantation by cutting is said to be difficult, and Paraserianthes falcataria Becker useful as a material for plywood, and may be used by a simple technique such as spraying.

摘要翻译： 植物根部诱导剂包括具有5-24个碳原子的酮醇不饱和脂肪酸，碳原子与α酮醇结构或γ酮醇结构之间的1-6个双键（特别是9-羟基-10-氧代-12（Z ）中，优选15（Z） - 十八碳二烯酸），即使通过切割松树，雪松，茶，栗子等难生根的植物进行移栽时，也可以使用植物根诱导剂来促进或诱导根生长 ，甚至可用于根部生长被认为是不可能的樱桃（Prunus xyedoensis）（樱桃树）插条的根部生长，据说通过切割移植的金丝桃是困难的，并且Paraserianthes falcataria Becker可用作胶合板材料 并且可以通过诸如喷涂的简单技术来使用。

公开(公告)号：EP1733738A1

公开(公告)日：2006-12-20

申请号：EP05721547.7

申请日：2005-03-18

申请人： SHISEIDO COMPANY, LTD.

发明人： KATAGIRI, Chika c/o SHISEIDO RESEARCH CENTER ,  HIBINO, Toshihiko c/o SHISEIDO RESEARCH CENTER

IPC分类号： A61K45/00

CPC分类号： C07K14/47 ,  A61K8/606 ,  A61K48/00 ,  A61Q17/04 ,  G01N33/6893 ,  G01N2510/00 ,  G01N2800/20

摘要： The present invention provides a method for enhancing resistance to the onset of skin damage caused by irradiation of the skin with ultraviolet light by inhibiting ultraviolet irradiation-induced apoptosis of epidermal cells as a result of increasing expression of SCCA-1 and/or SCCA-2 in epidermal cells. Moreover, the present invention provides a skin testing method for evaluating resistance of the skin to skin damage caused by ultraviolet irradiation by measuring the expression of SCCA-1 and/or SCCA-2 in epidermal cells, and judging UV resistance of the epidermis to be weak in the case expression is decreased as compared with expression in epidermal cells. Moreover, the present invention provides a method for screening drugs which enhance resistance of the skin to skin damage by ultraviolet irradiation by selecting a drug that increases expression of SCCA-1 and/or SCCA-2 as a UV resistance enhancer.

摘要翻译： 本发明提供一种通过抑制紫外线照射诱导的表皮细胞凋亡，由于SCCA-1和/或SCCA-2的表达增加而增强对紫外线照射引起的皮肤损伤发作的抗性的方法 在表皮细胞中。 此外，本发明提供了一种皮肤测试方法，用于通过测量表皮细胞中SCCA-1和/或SCCA-2的表达来评估皮肤对紫外线照射引起的皮肤损伤的抗性，并将表皮的抗紫外线性判断为 与表皮细胞中的表达相比，病例表达较弱。 此外，本发明提供一种通过选择增加作为抗紫外线增强剂的SCCA-1和/或SCCA-2的表达的药物，通过紫外线照射来增强皮肤对皮肤损伤的抗性的药物的方法。