公开(公告)号：EP3831850A1

公开(公告)日：2021-06-09

申请号：EP19814717.5

申请日：2019-06-06

申请人： BioRay Pharmaceutical Co., Ltd.

发明人： WANG, Haibin ,  HU, Feng ,  ZHANG, Xuan ,  JIAO, Jingyu ,  WU, Zhenhua ,  GAO, Dong

IPC分类号： C07K16/28 ,  A61K39/00 ,  C12N5/10 ,  C12N15/06 ,  A61P35/00

摘要： Disclosed in the present invention are antibodies to programmed death ligand (PD-L1) and an application thereof, and in particular, an application thereof in treating and/or preventing PD-L1 related conditions.

公开(公告)号：EP3380611A1

公开(公告)日：2018-10-03

申请号：EP16867451.3

申请日：2016-11-23

申请人： Commonwealth Scientific and Industrial Research Organisation ,  University Of Georgia Research Foundation, Inc.

发明人： BEAN, Andrew ,  LOWENTHAL, John William ,  MALAVER-ORTEGA, Luis Fernando ,  TRIPP, Ralph A

IPC分类号： C12N15/00 ,  C12N7/00 ,  A61K39/00 ,  C12N15/06 ,  A61K39/155 ,  A61K39/145 ,  A61K39/17

CPC分类号： C12N7/02 ,  A61K39/145 ,  A61K39/17 ,  C12N7/00 ,  C12N2760/16051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2760/16334 ,  C12N2760/18251

摘要： The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.

公开(公告)号：EP2271748B1

公开(公告)日：2018-01-17

申请号：EP09723461.1

申请日：2009-03-19

申请人： University of Florida Research Foundation, Inc. ,  Bartelmez, Stephen H.

发明人： BARTELMEZ, Stephen, H. ,  GRANT, Maria

IPC分类号： C12N15/06 ,  A61K35/14 ,  C12N5/0789 ,  A61K35/28 ,  A61K35/44

CPC分类号： A61K35/28 ,  A61K2035/124 ,  C12N5/0647 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/3233 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2501/15

摘要： Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which TGF-&bgr; expression and/or activity has been transiently blocked. Other methods involve the administration of a TGF-&bgr; blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion. Alternatively, a TGF-&bgr; blocking agent and treated cells are co-administered to a subject in need thereof.

公开(公告)号：EP2408904A4

公开(公告)日：2013-02-27

申请号：EP10753012

申请日：2010-03-22

申请人： MESOBLAST INC

发明人： ITESCU SILVIU

IPC分类号： C12N5/077 ,  C12N15/06 ,  C12N15/07

CPC分类号： C12N5/0696 ,  C12N15/86 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/1353 ,  C12N2506/1361 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2740/15043 ,  G01N33/5073

摘要： The present invention provides a method of producing a reprogrammed cell, said method comprising exposing Stro-1+ multipotential cells and/or progeny cells thereof to one or more potency-determining factors under conditions sufficient to reprogram the cells. The present invention also provides cells produced by such a method and cells differentiated therefrom in addition to various uses of those cells.

公开(公告)号：EP2297191A4

公开(公告)日：2011-12-07

申请号：EP09793710

申请日：2009-07-08

申请人： COMMW SCIENT IND RES ORG

发明人： KHURANA JEEVAN L ,  JACKSON COLIN J ,  SCOTT COLIN ,  PANDEY GUNJAN ,  RUSSELL ROBYN J ,  OAKESHOTT JOHN G

IPC分类号： C07K14/35 ,  C07K1/04 ,  C12N15/05 ,  C12N15/06 ,  C12Q1/58

CPC分类号： C12N9/80 ,  C12N15/8259 ,  C12N15/8271 ,  G01N2333/98

公开(公告)号：EP2289943A4

公开(公告)日：2011-09-14

申请号：EP09750583

申请日：2009-05-19

申请人： OTSUKA PHARMA CO LTD ,  UNIV TOKYO SCIENCE

发明人： AZUMA TAKACHIKA ,  TAKIZAWA HISAO

IPC分类号： C07K16/42 ,  C12N5/12 ,  C12N15/06 ,  C12P21/08

CPC分类号： C07K16/42 ,  C07K16/44 ,  C07K2317/32

公开(公告)号：EP2158314A4

公开(公告)日：2010-08-25

申请号：EP09748006

申请日：2009-03-31

申请人： UNIV PUTRA MALAYSIA

发明人： B CHE MAN YAAKOB ,  MUSTAFA SHUHAIMI ,  KHALID FARIHAH LIYANA ,  AZMI AIDA AZRINA ,  SAZILI AWIS QURNI ,  ABDUL RAHIM RAHA

IPC分类号： C12N15/06 ,  C12Q1/68 ,  C12N15/10 ,  C12N15/11

CPC分类号： C12Q1/6888 ,  C12Q2600/124

公开(公告)号：EP2205735A2

公开(公告)日：2010-07-14

申请号：EP08830138.7

申请日：2008-09-16

申请人： Instytut Hodowli I Aklimatyzacji Roslin

发明人： PRZEWODOWSKI, Wlodzimierz

IPC分类号： C12N15/06 ,  G01N33/53 ,  C07K16/12

CPC分类号： C07K16/1285 ,  C07K14/34 ,  C07K2317/55 ,  C12Q1/04 ,  C12Q1/045 ,  G01N33/56911

摘要： The use of a bacterial antigen obtained from bacterial cells in the production of antibodies for immunological assays for detecting bacterial cells.

公开(公告)号：EP2126071A1

公开(公告)日：2009-12-02

申请号：EP07853012.8

申请日：2007-10-29

申请人： Synageva BioPharma Corp.

发明人： HARVEY, Alex, J. ,  RAPP, Jeffrey, C.

IPC分类号： C12N15/06 ,  C12N15/09

CPC分类号： A01K67/0278 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2227/30 ,  A01K2267/01 ,  C07K14/56 ,  C07K14/70521 ,  C07K2319/30 ,  C12N7/00 ,  C12N15/8509 ,  C12N15/86 ,  C12N2015/8518 ,  C12N2740/11043 ,  C12N2800/24 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/90

摘要： A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.

公开(公告)号：EP1206530B1

公开(公告)日：2009-06-17

申请号：EP00955297.7

申请日：2000-08-01

申请人： Merck & Co., Inc.

发明人： MEI, Qin ,  RUSHMORE, Thomas, H. ,  SHOU, Magang

IPC分类号： C12N15/02 ,  C12N15/06 ,  C12N15/08 ,  C07K16/00 ,  C12P21/08 ,  G01N33/53 ,  A61K39/00 ,  C07K16/40 ,  C12N9/02

CPC分类号： C12Q1/26 ,  C07K16/40 ,  C12N2799/026 ,  G01N33/573 ,  G01N2333/795 ,  G01N2333/80 ,  G01N2333/90245