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383 条记录 (耗时 0.018 秒)

    DERIVES DE METHYL-BIPHENYLE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION
    122.
    发明公开
    DERIVES DE METHYL-BIPHENYLE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION 有权
    甲基联苯衍生物，制备方法和用途

    公开(公告)号：EP1066248A1

    公开(公告)日：2001-01-10

    申请号：EP99909013.7

    申请日：1999-03-17

    申请人： Sanofi-Synthélabo

    发明人： DORMOY, Jean-Robert ,  GOUBET, Dominique ,  MOREAU, Patrice

    IPC分类号： C07C251/24 ,  C07C251/48 ,  C07C255/50

    CPC分类号： C07C251/48 ,  C07C251/24

    摘要： The invention concerns: a) methyl-phenyl derivatives of general formula (I) wherein R1 represents OH, C3-C7 alkyl, or C3-C7 cycloalkyl, said compounds being in the form of individual isomers or mixtures thereof; b) the method for preparing them by reacting: either a hydroxylamine salt with an N-substituted o-(p-tolyl)-benzaldimine to obtain o-(p-tolyl)-benzaldoxime; or an N-substituted 2-halobenzaldimine with a p-tolylmagnesium halide in the presence of a manganese mineral derivative, to obtain the compounds of formula (I) wherein R1 represents C3-C7 alkyl or C3-C7 cycloalkyl; c) their use for preparing o-(p-tolyl)-benzonitrile, intermediate in the synthesis of medicines.

    POLYDENTATE IMINES AND THEIR METAL COMPLEXES
    126.
    发明公开
    POLYDENTATE IMINES AND THEIR METAL COMPLEXES 失效
    齿亚胺和它们的金属络合物

    公开(公告)号：EP1015419A1

    公开(公告)日：2000-07-05

    申请号：EP98910837.8

    申请日：1998-03-06

    申请人： Nycomed Amersham PLC

    发明人： SCHRODER, Martin ,  DOBLE, Daniel, Martin, John

    IPC分类号： C07C251/08 ,  C07C251/24 ,  A61K49/00

    CPC分类号： C07F9/6515 ,  A61K49/06 ,  C07C251/08 ,  C07C251/24 ,  C07F9/3808

    摘要： Novel neutral, water soluble metal complexes, particularly those containing lanthanide metals, yttrium, indium or gallium, processes for their preparation, ligands involved in their preparation, pharmaceutical formulations containing them, and their use in diagnostic methods are disclosed. The compounds are represented by Formula (I) where: A is N, CR1, P, P=O, cis,cis,cis-1,3,5-trisubstituted-cyclohexane or an N,N',N''-trisubstituted-triaza 9 to 14 membered macrocyclic ring; L?1, L2, L3¿ are linker groups which are independently chosen from C¿1-4? alkylene, C4-6 cycloalkylene or C4-6 o-arylene; Y?1, Y2, Y3¿ are independently chosen from -NH¿2?, -B(=O)OZ, -N=CR-B(=O)OZ, -NR-CR2-B(=O)OZ, -N[CR2-B(=O)Q]2 and -O-CR2-B(=O)OZ, where B is C or PR?2¿, each Q is independently -OZ or -NR¿2? and Z is H or a counter-ion; each R and R?1¿ group is independently chosen from H, C¿1-5? alkyl, C1-5 alkoxyalkyl, C1-5 hydroxyalkyl, C1-5 aminoalkyl, C5-10 aryl or C1-6 fluoroalkyl; R?2¿ is OH, C¿1-6? alkyl, C1-6 alkoxyalkyl, C1-6 fluoroalkyl, C1-10 alkoxy or C5-10 aryl; with the proviso that at least one of Y?1, Y2, and Y3¿ is -N=CR-B(=O)OZ.

    Process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-(perfluoroalkylmethyl)arylimidoyl chloride compounds
    128.
    发明公开
    Process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-(perfluoroalkylmethyl)arylimidoyl chloride compounds 有权
    Verfahren zur Herstellung von 2-芳基-5-（全氟烷基）吡咯烷二酮N-（全氟烷基甲基）芳基亚氨基二苯并二茚

    公开(公告)号：EP0934930A1

    公开(公告)日：1999-08-11

    申请号：EP99300810.1

    申请日：1999-02-03

    申请人： American Cyanamid Company

    发明人： Kameswaran, Venkataraman

    IPC分类号： C07D207/416 ,  C07C251/24

    CPC分类号： C07D207/34

    摘要： There is provided a process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-(perfluoroalkylmethyl)arylimidoyl chloride compounds. The 2-aryl-5-(perfluoroalkyl)pyrrole compounds are useful for the control of insect and acarid pests, and may also be used to prepare other pesticidal arylpyrrole compounds.
    In addition, the present invention provides N-(perfluoroalkylmethyl)arylimidoyl chloride compounds which are useful as intermediates in the preparation of arylpyrrole compounds.

    摘要翻译： 式（I）的2-芳基-5-（全氟烷基）吡咯衍生物的制备包括使式（II）的N-（全氟烷基甲基）芳基亚氨基氯衍生物与式（III）的双亲体或α，β （Ⅳ）的二卤代化合物和碱，在溶剂的存在下进行。 （A）（C1）C = NCH2CnF2n + 1（Ⅱ）; （W）CH = C（Y）（Z）（III）; （Z）（W）CH-CH（Y）（Z）（Ⅳ）。 W = H或CmF2m + 1; Y = CN，NO2或CO2R; R = 1-4C烷基; m，n = 1-8; A =式（i）或（ii）的组; L = H或卤素; M，Q = H，卤素，CN，NO2，1-4C烷基，1-4C卤代烷基，1-4C烷氧基，1-4C卤代烷氧基，1-4C烷硫基，1-4C卤代烷硫基，1-4C烷基亚磺酰基， 卤代烷基亚磺酰基，1-4C烷基磺酰基，1-4C卤代烷基磺酰基; 或相邻的M + Q = OCH 2 O，OCF 2 O或CH = CH-CH = R1-R3 = H，卤素，NO2或CHO; R2 + R3 = C（R4）= C（R5） - （R6）= C（R7）; R4-R7 = H，卤素，CN或NO2; X = O或S; 和Z = Cl，Br或I.