公开(公告)号：EP1151143A4

公开(公告)日：2004-05-19

申请号：EP00913326

申请日：2000-02-01

申请人： GEN HOSPITAL CORP

发明人： SZOSTAK JACK W ,  ROBERTS RICHARD W ,  LIU RIHE

IPC分类号： C12N15/09 ,  C07B61/00 ,  C07H21/02 ,  C07H21/04 ,  C07K2/00 ,  C07K7/00 ,  C07K14/00 ,  C07K14/82 ,  C12N15/10 ,  C12N15/11 ,  C12P21/02 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/68

CPC分类号： C40B30/04 ,  C07B2200/11 ,  C07K14/82 ,  C07K2319/00 ,  C12N15/1062 ,  G01N33/6845

摘要： Described herein are RNA-protein fusion production methods which involve a high salt post-translational incubation step.

公开(公告)号：EP1406918A1

公开(公告)日：2004-04-14

申请号：EP02758965.4

申请日：2002-07-17

申请人： Keratec Limited

发明人： KELLY, Robert, James ,  WORTH, Gillian, Helen ,  RODDICK-LANZILOTTA, Ailsa, Dawn ,  RANKIN, Douglas, Alexander ,  ELLIS, Gregory, David ,  MESMAN, Paul, Johannes, Roy ,  SUMMERS, Conal, Garth ,  SINGLETON, Diane, Joyce

IPC分类号： C07K1/107 ,  C07K1/14 ,  C07K2/00

CPC分类号： C07K14/4741

摘要： A process for the preparation of soluble proteins of high molecular weight with little or no damage to the structural integrity of the proteins. The process is economically and environmentally acceptable by virtue of the cost of reagents that are used, and the recycling of some of those reagents, and is suitable for the production of soluble proteins on a large scale. The process includes a first stage using oxidative sulfitolysis followed by a second stage using mild conditions to extract the soluble protein. In the case of wool as the protein source the process leads to the production of soluble keratin proteins fractionated into the classes S-sulfonated keratin intermediate filament proteins and S-sulfontated keratin high sulfur proteins.

公开(公告)号：EP1401494A1

公开(公告)日：2004-03-31

申请号：EP02737250.7

申请日：2002-05-31

申请人： The Regents of the University of California

发明人： RAULET, D. H.,Dept. of Molecular and Cell Bio. ,  DIEFENBACH, A.,Dept. of Molecular and Cell Bio.

IPC分类号： A61K39/395 ,  A61K31/00 ,  A61K38/00 ,  G01N33/48 ,  A01N61/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K14/4726 ,  A61K38/00 ,  A61K2039/505 ,  C07K2319/00

摘要： Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and cytokines may be included to enhance the immune response. The composition may be cells comprising expression constructs for the ligands, liposomes or combinations of proteins molecules.

公开(公告)号：EP1383474A2

公开(公告)日：2004-01-28

申请号：EP02776548.6

申请日：2002-04-08

申请人： NEW YORK UNIVERSITY

发明人： ORLOW, Seth, J. ,  HALL, Andrea ,  MANGA, Prasheila

IPC分类号： A61K7/135 ,  A61K31/74 ,  A61K9/00 ,  A61K6/00 ,  A61K9/14 ,  A61K38/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/567

CPC分类号： A61K8/4906 ,  A61K8/72 ,  A61K31/56 ,  A61Q19/02 ,  C12Q1/26 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5035 ,  G01N33/5044 ,  G01N33/5076 ,  G01N33/5088 ,  G01N33/6881 ,  G01N2333/90219 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2800/207

摘要： The invention provides methods of screening for compounds that affect melanogenesis and the function of P protein in organisms, cells, or cell-free systems. The invention further relates to pharmacologic and cosmetic uses of methods of inhibiting melanogenesis, methods of activating melanogenesis, and compounds and pharmacologic compositions useful for the inhibition or activation of melanogenesis and, therefore, for lightening or darkening the pigmentation of cells and tissue, i.e., skin.

公开(公告)号：EP1368051A2

公开(公告)日：2003-12-10

申请号：EP02753685.3

申请日：2002-03-15

申请人： RESEARCH DEVELOPMENT FOUNDATION

发明人： VALE, Wylie, W., Jr. ,  RIVIER, Jean, E. ,  KUNITAKE, Koichi, S. ,  LEWIS, Kathy, A. ,  PERRIN, Marilyn, H. ,  GULYAS, Jozsef

IPC分类号： A61K38/00 ,  A61K38/12 ,  C07H21/04 ,  C07D239/02 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： A61K38/2228 ,  A61K38/00 ,  C07K14/57509 ,  C07K14/695

摘要： A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.

摘要翻译： 公众人类基因组数据库的搜索确定了人类EST，GenBank登录号AW293249，其与已知的河豚urocortin序列具有高同源性。 从人类基因组DNA扩增全长序列并进行测序。 新序列与人尿皮质素I和尿皮质素II的序列同源性比较显示，该序列编码新的人类乳皮质素，其命名为尿细胞素III（UcnIII）。 虽然urocortin III对CRF-R1或CRF-R2没有高亲和力，但对CRF-R2的亲和力大于对CRF-R1的亲和力。 Urocortin III能够刺激表达CRF-R2α或bgr的细胞中的环AMP产生。 因此，亲和力足够高，使得尿皮质素III可以作为CRF-R2的天然激动剂。 然而，urocortin III也可能是未被鉴定的受体的更强的激动剂。

公开(公告)号：EP1359883A2

公开(公告)日：2003-11-12

申请号：EP01273811.8

申请日：2001-11-09

申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY

发明人： MOCHLY-ROSEN, Daria

IPC分类号： A61K7/00 ,  A01N37/18 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： A61K38/177 ,  A61K47/64 ,  A61K47/645

摘要： A method of reducing damage to cells and tissue caused by an ischemic or hypoxic event is disclosed. The method includes administering to the cell or tissue, either in vivo or ex vivo , psi epsilon RACK peptide. The peptide can be administered before, during or after the ischemic or hypoxic event.

公开(公告)号：EP0863991B1

公开(公告)日：2003-11-05

申请号：EP96928443.9

申请日：1996-08-09

申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH

发明人： FARNOW, Dieter ,  KARLE, Joachim ,  POLIAKOV, Igor, D. ,  IVANOVA, Ludmilla, G.

IPC分类号： C12P21/00 ,  C12P19/04 ,  A61K39/00 ,  C08B37/00 ,  C07K2/00 ,  C12N1/16

CPC分类号： C12R1/725 ,  A61K39/00 ,  A61K39/0002 ,  C07K2/00 ,  C08B37/00 ,  C12P19/04 ,  C12P21/005 ,  Y10S435/911 ,  Y10S435/922

摘要： The present invention relates to antigenic preparations comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, processes for the preparation of these antigenic preparations, their use as pharmaceutical substances as well as their use as vaccines, including but not limited to, the prophylaxis and treatment of allergy, as well as for modulating the immune response.

公开(公告)号：EP0858463B1

公开(公告)日：2003-09-17

申请号：EP96922631.5

申请日：1996-07-01

申请人： Midwest Grain Products

发明人： BASSI, Sukh ,  MANINGAT, Clodualdo, C. ,  CHINNASWAMY, Rangaswamy ,  GRAY, Darren, R. ,  NIE, Li

IPC分类号： C07K1/30 ,  C07K2/00 ,  C07K14/415

CPC分类号： C07K14/415

摘要： An improved alcohol-free method for fractionating gluten into gliadin and glutenin fractions is provided where an acidic dispersion of gluten is formed with a reducing agent (e.g., sodium metabisulfite) operable for breaking disulfide bonds in the gluten protein. Thereafter, the pH of the dispersion is raised to cause glutenin to precipitate while leaving gliadin suspended in the dispersion. The respective fractions can then be separated by decanting or centrifugation. In preferred processing, the dispersion is reacidified prior to separation in order to achieve a higher degree of separation of the glutenin and gliadin.

公开(公告)号：EP0973391A4

公开(公告)日：2003-09-03

申请号：EP97932262

申请日：1997-06-19

申请人： UNIV CALIFORNIA

发明人： DE ROBERTIS EDWARD M ,  BOUWMEESTER TEWIS

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/475 ,  C07K19/00 ,  A01N37/18 ,  C07H21/02 ,  C07H21/04 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K14/475 ,  A61K38/00

摘要： Novel proteins have been designated "cerberus" and "frzb-1", respectively. Cerebus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed specifically in the head organizer region. This new molecule has endodermal, cardiac, and neural tissue inducing activity, that should prove useful in therapeutic, diagnostic, and clinical applications requiring regeneration, differentiation, or repair of these and other tissues. Frzb-1 is a soluble antagonist of growth factors of the Wnt family that acts by binding to Wnt growth factors in the extracellular space. A third novel protein is termed PAPC which promotes the formation of dorsal mesoderm and somites in the embryo.

公开(公告)号：EP1311280A2

公开(公告)日：2003-05-21

申请号：EP01956077.0

申请日：2001-08-01

申请人： THE UNIVERSITY OF KANSAS

发明人： SIAHAAN, Teruna, J. ,  YUSUF-MAKAGIANSAR, Helena ,  ANDERSON, Meagan ,  XU, Rong, Christine

IPC分类号： A61K38/03 ,  C07K2/00 ,  C07K19/00

CPC分类号： A61K47/62

摘要： Peptides which bind to leukocytes are conjugated with drugs. Advantageously, the peptide-drug conjugates interfere with ICAM-1/LFA-1 interactions and are internalized by leukocytes, whereby the drug portion of the conjugate exerts potent toxic side effects against targeted cells with minimal adverse side effects. Preferred conjugates include 4-30 mer peptides derived from ICAM-1 or LFA-1 coupled with drugs effective against leukocyte-related diseases.