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131.发明公开INDOLE AND INDOLINE CYCLOPROPYL AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS 有权吲哚和吲哚环丙酰胺衍生物作为EP4受体拮抗剂
公开(公告)号：EP2114877A4
公开(公告)日：2010-10-27
申请号：EP08714673
申请日：2008-02-22
发明人： BOYD MICHAEL , COLUCCI JOHN , HAN YONGXIN
IPC分类号： C07D209/08 , A61K31/404 , A61K31/41 , C07D403/12
CPC分类号： C07D209/08 , C07D209/42 , C07D403/12
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132.发明公开NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开作为硬脂酰辅酶A-9去饱和酶抑制剂的新型杂芳族化合物
公开(公告)号：EP2231649A1
公开(公告)日：2010-09-29
申请号：EP08858955.1
申请日：2008-12-09
IPC分类号： C07D413/04 , A61K31/395 , A61K31/42 , A61K31/425 , A61P3/04 , A61P3/06 , A61P3/10 , A61P35/00 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/14
CPC分类号： C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04
摘要： Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. HetAr_W_X_Ar (I)
摘要翻译： 结构式I的杂芳族化合物是硬脂酰 - 辅酶A-9去饱和酶（SCD）的抑制剂。 本发明化合物可用于预防和治疗与脂质合成和代谢异常相关的病症，包括心血管疾病; 动脉粥样硬化; 肥胖; 糖尿病; 神经疾病; 代谢综合征; 胰岛素抵抗; 癌症; 肝脂肪变性; 和非酒精性脂肪性肝炎。 HetAr_W_X_Ar（I）
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公开(公告)号：EP2217071A1
公开(公告)日：2010-08-18
申请号：EP08795218.0
申请日：2008-08-12
发明人： BILLS, Gerald, F. , COLLADO, Javier , PARISH, Craig, A. , PELAEZ, Fernando , PLATAS, Gonzalo , ROEMER, Terry
CPC分类号： A01N65/04 , A01N43/90 , A01N65/00 , A61K31/42 , C07D498/16
摘要： Novel isoxazolidinone compounds useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops are described. Two novel strains of fungi, ATCC No. PAT-7894 and ATCC No. PAT-7895, are disclosed for the preparation of the described isoxazolidinone compounds.
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公开(公告)号：EP2162436A4
公开(公告)日：2010-08-04
申请号：EP08757142
申请日：2008-05-23
发明人： WU TOM YAO-HSIANG , JUTEAU HELENE , GALLANT MICHEL , DUBE DANIEL , ROY PATRICK , ASPIOTIS RENEE , GRIMM ERICH L , LALIBERTE SEBASTIEN , CHEN AUSTIN
IPC分类号： C07D211/60 , A61K31/451 , A61K31/4523 , A61K31/5377 , A61P9/00 , A61P13/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12
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公开(公告)号：EP1910272A4
公开(公告)日：2010-08-04
申请号：EP06761157
申请日：2006-07-20
发明人： BAYLY CHRISTOPHER I , CHEN AUSTIN C , DUBE DANIEL , DUBE LAURENCE , GALLANT MICHEL , LACOMBE PATRICK , MACDONALD DWIGHT , MCKAY DANIEL , POWELL DAVID A , GRIMM ERICH L
IPC分类号： C07C237/20 , C07C317/10 , C07D211/40 , C07D215/12 , C07D215/14 , C07D401/06 , C07D413/12
CPC分类号： C07C317/28 , C07C269/06 , C07C317/18 , C07C317/22 , C07C323/12 , C07C2601/02 , C07C2601/04 , C07D207/27 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/64 , C07D215/12 , C07D401/06 , C07C271/22
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公开(公告)号：EP2209769A1
公开(公告)日：2010-07-28
申请号：EP08842725.7
申请日：2008-10-23
发明人： O'SHEA, Paul
IPC分类号： C07D215/18 , A61K31/47 , A61K31/573 , A61K31/58 , A61P11/06
CPC分类号： C07D215/18
摘要： The present application relates to crystalline 1,2-ethanedisulfonic acid salt and N,N'-dibenzylethylenediamine salt of montelukast. The salts are useful as therapeutic agents for the treatment of leukotriene mediated diseases and disorders. This application also relates to processes and intermediates for preparing the said salts and pharmaceutical compositions comprising the salts and optionally other therapeutic agents.
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公开(公告)号：EP1613621B1
公开(公告)日：2010-07-21
申请号：EP04723484.4
申请日：2004-03-26
IPC分类号： C07D409/06 , C07D211/74 , C07D401/06 , A61K31/4412 , A61P27/06 , C07D265/10 , C07D279/06 , C07D413/06 , C07D417/06 , C07D403/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D405/06
CPC分类号： C07D211/74 , C07D211/76 , C07D265/10 , C07D401/06 , C07D409/06
摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.
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138.发明公开AZACYCLOHEXANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开AZACYCLOHEXANDERIVATE AS硬脂酰辅酶AΔ9去饱和酶的抑制剂
公开(公告)号：EP1951731A4
公开(公告)日：2010-07-07
申请号：EP06804718
申请日：2006-11-10
IPC分类号： C07D513/04 , A61K31/519 , A61K31/53 , A61P3/00 , C07D473/04 , C07D487/04 , C07D498/04
CPC分类号： C07D473/18 , C07D473/04 , C07D473/16 , C07D513/04
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公开(公告)号：EP2188256A1
公开(公告)日：2010-05-26
申请号：EP08783340.6
申请日：2008-08-04
发明人： DUBE, Daniel , CHEN, Austin , MCKAY, Daniel J.
IPC分类号： C07D213/75 , A61K31/165 , A61K31/4045 , A61K31/44 , A61K31/4406 , A61P9/00 , C07C237/08 , C07D209/08 , C07D213/56
CPC分类号： C07D209/08 , C07C237/20 , C07C2601/02 , C07D213/56 , C07D213/73
摘要： The present invention relates to acyclic amino amides of formula (I). These compounds are renin inhibitors of a non-peptidic nature and of low molecular weight. The invention further relates to processes for the preparation of these compounds, pharmaceutical compositions containing them, as well as their use and method of treatment of cardiovascular events and renal insufficiency.
摘要翻译： 式（I）的无环氨基酰胺本发明涉及式（I）的无环氨基酰胺。 这些化合物是非肽类性质和低分子量的肾素抑制剂。 本发明进一步涉及制备这些化合物的方法，含有它们的药物组合物，以及它们的用途和治疗心血管事件和肾功能不全的方法。
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公开(公告)号：EP1885722A4
公开(公告)日：2010-02-24
申请号：EP06741503
申请日：2006-05-15
发明人： BELLEY MICHEL , BURCH JASON , COLUCCI JOHN , FARAND JULIE , GIRARD MARIO , HAN YONGXIN
IPC分类号： C07D471/04 , A61K31/435 , A61K31/44 , A61K31/4745 , A61K31/498 , A61K31/501 , A61P29/00
CPC分类号： C07D471/04
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