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131.发明公开FILTER SYSTEMS FOR SEPARATING MICROCARRIERS FROM CELL CULTURE SOLUTIONS 有权过滤器ZUR TRENNUNG VONMIKROTRÄGERNAUSZELLKULTURLÖSUNGEN
公开(公告)号：EP2760988A1
公开(公告)日：2014-08-06
申请号：EP12769849.6
申请日：2012-09-24
IPC分类号： C12M1/00
CPC分类号： C12M29/04 , B01D29/13 , B01D29/27 , B01D35/027 , C12M23/14 , C12M23/26 , C12M25/16 , C12M33/14 , C12M47/02
摘要： A filter assembly for separating microcarriers from a fluid medium includes a collapsible container bounding a sterile compartment adapted to hold a fluid. An inlet port is attached to the container through which fluid flows into the compartment. An outlet port is attached to the container through which fluid flows out of the compartment. A filter is disposed within the compartment, the filter dividing the compartment into an inlet chamber that is fluidly coupled with the inlet port and an outlet chamber that is fluidly coupled with the outlet port, the filter allowing a medium to pass therethrough but preventing microcarriers disposed in the medium from passing therethrough.
摘要翻译： 用于将微载体与流体介质分离的过滤器组件包括界定适于保持流体的无菌隔室的可折叠容器。 入口连接到容器，流体通过该入口进入隔室。 出口端口连接到容器，流体通过该容器流出隔室。 过滤器设置在隔间内，过滤器将隔室分隔成与入口端口流体连接的入口室和与出口端口流体连接的出口室，过滤器允许介质通过，但防止微载体处置 在介质中通过。
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公开(公告)号：EP2652120A1
公开(公告)日：2013-10-23
申请号：EP11848049.0
申请日：2011-12-07
申请人： Drugmode APS
摘要： There is provided a bioreactor which is provided with a lid (13) that facilitates access to the incubation cavity. Specifically the end wall of the incubation cavity is constituted by the lid (13) so that removal of the cap renders the incubation cavity fully accessible.
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133.发明公开
公开(公告)号：EP2605012A1
公开(公告)日：2013-06-19
申请号：EP12196935.6
申请日：2012-12-13
发明人： Sim, Tae-seok , Kim, Min-seoks. , Song, Mi-jeong , Lee, Jeong-gun , Lee, June-young , Kim, Yeon-jeong , Baek, Sang-hyun , Oh, Jin-mi , Jeong, Hyo-young
CPC分类号： G01N1/34 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0668 , B01L2300/0681 , B01L2300/0803 , B01L2300/0816 , B01L2300/087 , B01L2400/086 , C12M33/14 , C12M47/04 , G01N1/4077
摘要： Embodiments disclose a cell capturing filter, in which cells or particles having a predetermined size or greater in a sample may be easily captured, and clogging of a flow passage due to the captured cells or particles may be prevented, and stresses acting on the captured cells or particles may be reduced. The filter has a first substrate having a first surface and a second substrate having a second surface that is bonded to the first surface, wherein the first substrate may include a flow passage formed in the first surface of the first substrate so that a sample flows in the flow passage, and a barrier that protrudes across the flow passage, and the second substrate may include a fine groove formed in an area on the second surface corresponding to the barrier, and a gap may exist between a surface of the barrier and the fine groove.
摘要翻译： 实施方案公开了一种细胞捕获过滤器，其中可以容易地捕获样品中具有预定尺寸或更大尺寸的细胞或颗粒，并且可以防止由于捕获的细胞或颗粒引起的流动通道的堵塞，并且可以防止作用在捕获的细胞上的应力 或者可以减少颗粒。 所述过滤器具有第一衬底，所述第一衬底具有第一表面，所述第二衬底具有接合到所述第一表面的第二表面，其中所述第一衬底可以包括形成在所述第一衬底的所述第一表面中的流路，使得样品流入 流动通道和跨过流动通道突出的屏障，并且第二基板可以包括形成在与屏障相对应的第二表面上的区域中的细槽，并且在屏障的表面和精细之间可能存在间隙 槽。
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公开(公告)号：EP2524025A1
公开(公告)日：2012-11-21
申请号：EP11702712.8
申请日：2011-01-12
发明人： WAICHE, Gaël , KUKUCZKA, Monika
IPC分类号： C12M1/12
摘要： A method for transferring a filter membrane (130) bearing a retentate to a reagent pad (310), in which the membrane is mounted in a support frame (120) having a shoulder (121) and a skirt (122) projecting from the shoulder, the pad being mounted on a cassette (300) of complementary form to said skirt, the skirt being adapted to slide sealingly on the cassette until it comes into abutment formed by the shoulder, the method comprising the steps of sealingly engaging the skirt of the membrane support frame on the cassette, establishing a pressure difference between the cassette and the membrane support frame such that the membrane adopts the shape of a dome pointing towards the pad, while maintaining the pressure difference, applying a force on the frame so as to make the skirt slide on the cassette until contact is established between the end of the dome and the pad, maintaining a force on the frame so as to move it downward until it comes into abutment formed by the shoulder while maintaining the pressure difference.
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135.发明授权FILTRATIONSEINHEIT UND VERFAHREN ZUR MIKROBIOLOGISCHEN UNTERSUCHUNG FLÜSSIGER PROBEN 有权过滤单元和方法液体样品的微生物检验
公开(公告)号：EP2139982B1
公开(公告)日：2012-05-16
申请号：EP08715812.7
申请日：2008-02-16
发明人： PFLANZ, Karl
IPC分类号： C12M1/12 , C12M1/22 , B01D29/085
CPC分类号： C12M33/14 , B01D63/087 , B01D2313/02 , B01D2313/21 , B01D2313/56 , B01D2315/08 , C12M23/10 , C12M23/38 , C12M23/46
摘要： The invention relates to a filtration unit, comprising a membrane filter that can be disposed on a filter support of a bottom part and an attachment that can be placed on the bottom part, wherein the membrane filter has a reinforcing edge, and wherein the membrane filter can be clamped to a clamping part of a cover of a culture medium unit for removal purposes and introduced into the culture media unit. The invention further relates to a method for the microbiological analysis of liquid samples following a filtration process, wherein after removing an attachment a membrane filter is lifted off a filter support for pouring in the liquid sample and set down on a surface of a culture medium disposed in the bottom part of a culture medium unit, and the bottom part is covered by a cover. The cover is placed on the membrane resting on the filter support such that a clamping part present on the filter support clamps to a reinforcing edge of the membrane. The cover is lifted off the filter support together with the membrane and placed on the bowl-shaped bottom part such that the bottom of the membrane facing away from the cover rests on the top of the nutrient medium facing the cover.
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公开(公告)号：EP2169048A3
公开(公告)日：2010-12-08
申请号：EP09010406.8
申请日：2009-08-12
发明人： Shibuya, Keisuke , Haga, Ryoichi , Namba, Masaru
IPC分类号： C12M1/36
摘要： A state of cells while being cultivated is ascertained and a feed medium suitable for the cell state is added for producing a target substance to be produced with a high yield. The system for cultivating cells of the invention includes a bioreactor/fermentor for cultivating cells to be cultivated, a measuring device for measuring the culture cells being cultivated in the bioreactor/fermentor or a component contained in the culture solution, and a control device for selecting a feed medium to be added to the bioreactor/fermentor from two or more feed media having different composition ratios based on the culture cells state determined by measured values obtained by the measuring device.
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137.发明公开Method and device for fermenting wet biomass 审中-公开Verfahren und Vorrichtung zur Fermentierung nasser Biomasse
公开(公告)号：EP2210934A1
公开(公告)日：2010-07-28
申请号：EP10151468.5
申请日：2010-01-22
申请人： Host B.V.
CPC分类号： C12M21/04 , C12M27/02 , C12M33/14 , Y02E50/343
摘要： The invention relates to a method for fermenting wet biomass, wherein use is made of a device (1) according to the invention, comprising:
- a tank (2) provided with an inlet (3) for admitting material for fermenting and provided with an outlet (4) for discharging fermented material;
- a discharge (5) in gas throughflow connection with the tank for discharging produced biogas; and
- stirring means (6) for stirring and mixing material present in the tank,
wherein
material present in the tank is stirred in a manner such that the mixing is incomplete and multiple zones (2a,2b,2c) form in the tank with dry matter contents differing from each other.摘要翻译： 本发明涉及一种用于发酵湿生物质的方法，其中使用根据本发明的装置（1），其包括： - 罐（2），其设置有用于容纳发酵材料的入口（3） 出口（4）用于排放发酵物料; - 与用于排放生成的沼气的罐的气体通过流动连接的排出口（5）; 和 - 用于搅拌和混合存在于罐中的材料的搅拌装置（6），其中存在于罐中的材料以使得混合不完全的方式被搅拌，并且在槽中形成多个区域（2a，2b，2c） 物质内容彼此不同。
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公开(公告)号：EP2165193A1
公开(公告)日：2010-03-24
申请号：EP08756847.3
申请日：2008-07-02
申请人： mbOnline Gmbh
发明人： LENDENFELD, Thomas
IPC分类号： G01N33/18
摘要： An apparatus for continuously, periodically monitoring water for microbial germs, having a reactor (5) and at least one reagent feed line (18a..d) to the reactor and at least one metering device (19a..d) for reagents as well as at least one measuring device (16) for detecting the presence of microorganisms, wherein the reactor (5) has a reactor chamber (11) and a filtrate chamber (13) which is separated from the latter by a filter (12), a water feed line (1) and a reagent feed line (18a...d) open into the reactor chamber and at least one water discharge line leads from the filtrate chamber, and a controller (10) is set up to use pump/valve means (3, 4, 6, 7) to lead a predefinable quantity of water into the reactor chamber and through the filter and to introduce a predefinable quantity of reagent into the reactor chamber.
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139.发明公开EXTRA-CAPILLARY FLUID CYCLING SYSTEM AND METHOD FOR A CELL CULTURE DEVICE 有权AUSSERKAPILLÄRES液循环的系统和方法
公开(公告)号：EP2027247A2
公开(公告)日：2009-02-25
申请号：EP07777189.7
申请日：2007-05-21
CPC分类号： C12M41/40 , A61K35/12 , C12M23/26 , C12M23/28 , C12M23/34 , C12M23/44 , C12M23/58 , C12M25/10 , C12M27/00 , C12M29/00 , C12M29/10 , C12M29/18 , C12M33/14 , C12M41/20 , C12M41/26 , C12M41/34 , C12M41/38 , C12M41/48 , C12M47/04 , C12M47/10 , C12M47/12 , C12M47/20 , C12Q3/00 , F04B43/0072 , F04B43/09 , F04B43/12 , F04B43/1292
摘要： An extra-capillary fluid cycling unit (40) for maintaining and cycling fluid volumes in a cell culture chamber includes a housing (50) and a first flexible extra-capillary fluid reservoir (42) disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir (44) is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate (46) is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
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