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公开(公告)号：EP0751994A1
公开(公告)日：1997-01-08
申请号：EP95914850.0
申请日：1995-03-23
CPC分类号： C07K14/4712 , A61K38/00 , A61K48/00
摘要： Provided are novel DNA molecules that include a nucleotide sequence encoding novel truncated CFTR polypeptides that have functional Cystic Fibrosis transmembrane conductance regulator (CFTR) protein biological activity. Also provided are the novel truncated CFTR polypeptides that possess the functional CFTR biological activity. The novel polypeptides act as regulated epithelial cell anion (Cl-) channels.
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公开(公告)号：EP0743839A1
公开(公告)日：1996-11-27
申请号：EP95910167.0
申请日：1995-02-09
CPC分类号： A61N1/0539 , A61F11/04 , A61N1/05 , A61N1/0529 , A61N1/0531 , A61N1/0541 , A61N1/36036 , A61N1/361
摘要： A neural prosthetic device (100') for a primary auditory cortex (150') of a patient includes a support (108') arranged in said primary auditory cortex having a plurality of electrical contacts (104') which output electrical discharges in accordance with processed electrical signals. The device can enable certain types of hearing impaired patients to hear. One version of the device can be wireless. A neural prosthetic device, which may or may not be wireless, can also be modified to reduce or eliminate the effects of tinnitus. In version, a catheter microinfuses drugs which suppress or eliminate abnormal neural activity.
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公开(公告)号：EP0542996A1
公开(公告)日：1993-05-26
申请号：EP92913831.0
申请日：1992-05-27
摘要： Des procédés chimioenzymatiques de production de polymères à base de sucre ainsi que des nouveaux polymères à base de sucre sont décrits. Dans un mode de réalisation, des sucres acylés sont copolymérisés avec des coréactifs pour produire de nouveaux polymères à base de sucre. Dans un autre mode de réalisation, les sucres non réducteurs acylés avec un composé ayant une double liaison terminale sont polymérisés pour produire les nouveaux polymères à base de sucre.
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144.发明公开ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS 失效ANALOGKOHLENSÄURE酸酐酶抑制剂及其作为外部应用程序抑制剂眼压。
公开(公告)号：EP0539527A1
公开(公告)日：1993-05-05
申请号：EP91918638.0
申请日：1991-06-03
CPC分类号： C07D285/135 , C07D277/80
摘要： On a préparé des analogues des inhibiteurs d'anhydrase carbonique dérivés de méthazolamide, et dichlorephénamide. Les analogues lient un groupe fonctionnel clivable à l'inhibiteur d'anhydrase carbonique pharmacologiquement acif se trouvant dans des composés d'une perméabilité cornéenne améliorée, lesquels n'irritent pas les yeux et sont localement efficaces pour inhiber la pression intra-oculaire.
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公开(公告)号：EP0158642A1
公开(公告)日：1985-10-23
申请号：EP84903224.0
申请日：1984-08-13
CPC分类号： C12M33/12 , C12M23/08 , C12M27/12 , C12N1/02 , C12N13/00 , H01L31/1844 , Y02E10/544
摘要： Technique de récolte de cellules de mammifères à partir d'un substrat artificiel, utilisant de l'énergie ultrasonique dans la gamme comprise entre 5 et 20 joules/cm2, avec une intensité variable entre 30 et 150 mW/cm2 et à une fréquence allant de 20 à 60 kHz.
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公开(公告)号：EP3508501B1
公开(公告)日：2024-11-06
申请号：EP18208809.6
申请日：2012-05-21
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公开(公告)号：EP4338672A3
公开(公告)日：2024-07-17
申请号：EP22185761.8
申请日：2016-12-05
发明人： CROMWELL, John , SHINOZAKI, Gen
CPC分类号： A61B5/7221 , A61B5/7267 , A61B5/0006 , A61B5/7275 , A61B5/7257 , A61B5/726 , A61B2505/0120130101 , G16H40/63 , A61B5/165 , A61B5/742 , A61B5/374
摘要： The disclosed apparatus, systems and methods relate to predicting, screening, and monitoring for delirium. Systems and methods may include receiving one or more signals from one or more sensing devices; processing the one or more signals to extract one or more features from the one or more signals; analyzing the one or more features to determine one or more values for each of the one or more features; comparing at least one of the one or more values or a measure based on at least one of the one or more values to a threshold; determining a presence, absence, or likelihood of the subsequent development of delirium for a patient based on the comparison; and outputting an indication of the presence, absence, or likelihood of the subsequent development of delirium for the patient.
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公开(公告)号：EP4372090A2
公开(公告)日：2024-05-22
申请号：EP23219520.6
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/63 , C12N15/111 , C12N15/1137 , C12N2310/1020130101 , C12N2310/2020170501 , C12N9/22
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
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公开(公告)号：EP3024497B1
公开(公告)日：2021-01-13
申请号：EP14829704.7
申请日：2014-07-20
IPC分类号： A61K48/00 , C12N15/864
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150.发明授权
公开(公告)号：EP3071240B1
公开(公告)日：2021-01-06
申请号：EP14863892.7
申请日：2014-11-20
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