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公开(公告)号：EP0179483A3
公开(公告)日：1989-03-01
申请号：EP85113585.5
申请日：1985-10-25
IPC分类号： C12P21/08
CPC分类号： C07K16/082
摘要： Disclosed are monoclonal antibodies to the HBsAg which are prepared by forming hybridomas between human peripheral blood lymphocyte cells, derived from humans having high titers of anti-HBsAg antibodies, and myeloma cells, cloning the hybridomas and selecting the antibody-producing clones. The monoclonal antibodies react with all the subtypes of the HBsAg and are very effective in diagnosis and treatment of diseases due to the viral infection.
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公开(公告)号：EP0173973A3
公开(公告)日：1988-08-10
申请号：EP85110915
申请日：1985-08-29
IPC分类号： G01N33/577 , G01N33/74 , C12P21/00 , C12R01/91
CPC分类号： G01N33/74
摘要： Described is a highly sensitive immunoassay method for determining the amounts of TSH contained in body fluids, in which an anti-β-subunit TSH monoclonal antibody having a specific association constant value is used.
摘要翻译： 描述了用于确定体液中含有的TSH的量的高度灵敏的免疫测定方法，其中使用具有特定关联常数值的抗β-亚基TSH单克隆抗体。
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143.发明公开Live vaccine for contagious diseases of chickens 失效LebendvaccinefürAnsteckungskrankheiten vonKüken。
公开(公告)号：EP0253389A1
公开(公告)日：1988-01-20
申请号：EP87110291.9
申请日：1987-07-16
发明人： Honda, Takashi , Taneno, Akira , Hanaki, Takuma , Eto, Masanobu
IPC分类号： A61K39/12 , A61K39/245 , A61K39/255 , A61K39/295
CPC分类号： A61K39/255 , A61K39/12 , A61K39/245 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C12N2710/16334 , Y10S424/816
摘要： A live vaccine for infectious laryngotracheitis, which comprises culture cells infected with attenuated infectious laryngotracheitis virus. Also, a live combined vaccine for infectious laryngotracheitis and Marek's disease, which comprises culture cells infected with attenuated viruses of these two diseases. These vaccines can be used on day-old (newborn) chicken, by subcutaneous or intramuscular injection, to give them immunity from infection by the virus or viruses.
摘要翻译： 用于传染性喉气管炎的活疫苗，其包含感染减毒感染性喉气管炎病毒的培养细胞。 另外，用于传染性喉气管炎和马立克氏病的活联合疫苗包括感染这两种疾病的减毒病毒的培养细胞。 这些疫苗可以通过皮下或肌内注射用于日龄（新生儿）鸡，使其免受病毒或病毒的感染。
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公开(公告)号：EP0171765A3
公开(公告)日：1988-01-13
申请号：EP85110011
申请日：1985-08-08
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , C12N2770/24134 , C12N2770/24151 , Y02A50/39
摘要： Disclosed is an improved method for the purification of Japanese encephalitis virus, which comprises subjecting a solution containing the Japanese encephalitis virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified Japanese encephalitis virus, which is useful for obtaining an effective vaccine against Japanese encephalitis.
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公开(公告)号：EP0140386A3
公开(公告)日：1987-03-04
申请号：EP84113134
申请日：1984-10-31
CPC分类号： C07K14/235 , A61K39/00 , Y10S435/822
摘要： Described is a method for producing highly pure LPF-HA (Leucocytosis-promoting Factor Hemagglutinin) from culture media of Bordetella pertussis in a high yield by an affinity chromatography using a denatured ceruloplasmin as a ligand. The LPF-HA obtained by this invention is highly pure and contains almost no endotoxin of B. pertussis and is useful for the preparation of various reagents utilizing the physiological activities, of a medicine for treating diabetes and of a pertussis vaccine.
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公开(公告)号：EP0193154A2
公开(公告)日：1986-09-03
申请号：EP86102363.8
申请日：1986-02-24
CPC分类号： G01N33/545 , G01N33/5438
摘要： Disclosed is a potential-causing element, in the form of an electrode or a membrane, for use in immunosensors, which comprises a polypyrrole or polythiophene film bound with an antigen or an antibody. The potential-causing element can be prepared in an easy manner through electrolytic polymerization of pyrrole or thiopene so as to control the thickness of the polymer film which will develop desired immunosresponse characteristics.
摘要翻译： 公开了用于免疫传感器的电极或膜形式的潜在的元素，其包含与抗原或抗体结合的聚吡咯或聚噻吩膜。 可以通过吡咯或噻吩的电解聚合以容易的方式制备潜在的元素，以便控制将产生所需免疫应答特性的聚合物膜的厚度。
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公开(公告)号：EP0152076A3
公开(公告)日：1986-08-13
申请号：EP85101354
申请日：1985-02-08
IPC分类号： C12N15/00 , C12P21/02 , C07K15/00 , C12N01/20 , G01N33/535
CPC分类号： C07K14/005 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2740/14022 , Y10S530/806 , Y10S530/808 , Y10S530/82 , Y10S530/825
摘要： Recombinant plasmids are constructed by inserting a DNA fragment coding for a fused protein of an adult T cell leukemia virus antigen peptide and an enzyme into a vector DNA. Microorganisms are transformed with the recombinant . plasmid and thereafter cultured to express the fused protein. The fused protein is useful for the detection and diagnosis of adult T cell leukamia.
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148.发明公开Nonspecific-reaction inhibitor in an immunological assay with monoclonal antibody 无效使用单克隆抗体在免疫学测试非特异性反应抑制剂。
公开(公告)号：EP0174026A2
公开(公告)日：1986-03-12
申请号：EP85111223.5
申请日：1985-09-05
发明人： Tsuji, Ichiroh , Unoki, Masanori , Aoyama, Noriaki
IPC分类号： G01N33/577
CPC分类号： G01N33/577 , G01N33/5306
摘要： Disclosed are certain animal sera and ascites that are useful for inhibiting the nonspecific-reactions occuring when carrying out an immunological assay with monoclonal antibodies (MCA). The use of the inhibitor makes the assay very accurate.
摘要翻译： 本发明公开了某些动物血清和腹水做是有用的用于抑制非特异性-反应存在的当用单克隆抗体（MCA）的免疫学测定进行。 使用抑制剂的使测定非常准确。
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149.发明授权Method for the preparation of improved mutant strain of bordetella bronchiseptica and live attenuated vaccine containing it 失效用于制备含有BORDETELLA BRONCHISEPTICA和灭活的灭活疫苗的改良突变体菌株的方法
公开(公告)号：EP0072656B1
公开(公告)日：1986-02-26
申请号：EP82304185.0
申请日：1982-08-09
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute , NIPPON VACCINE CO. LTD. , Shimizu, Takeshi
发明人： Shimizu, Takeshi
CPC分类号： C12N15/01 , A61K39/099 , A61K2039/522 , Y10S424/825 , Y10S424/83
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公开(公告)号：EP0171086A2
公开(公告)日：1986-02-12
申请号：EP85110012.3
申请日：1985-08-08
发明人： Oka, Tetsuya , Ohkuma, Kunio , Kawahara, Tetsuo , Sakoh, Mitsuo
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , C12N2760/16134 , C12N2760/16151
摘要： Disclosed is an improved method for the purification of an influenza virus, which comprises subjecting a solution containing the influenza virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified influenza virus which is useful for obtaining an effective vaccine against influenza.
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