摘要:
The present invention relates to a new class of plant growth regulators. In particular, the invention relates to 5-substituted-1-arylpyrazole-3-carboxylic acid derivative of general formula (I) and a method for treatment of plants with such compounds in order to induce growth regulating responses.
摘要:
Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要:
Disclosed are 4-sulfide / sulfoxide / sulfonyl-1H-pyrazolyl derivative compounds of formulas (I) or (II):wherein the variables n, R, R1, R2, R3, R3', R4, R4', R5 and R6 are as defined in the specification. The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor.
摘要:
Compounds of formula (I), wherein the variables and the index have the following meanings: R1 H, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkylthio, alkoxyalkyl, alkylthioalkyl, or optionally substituted phenyl; R2 H, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl or optionally substituted phenyl; A H, OH, CN, NO¿2?, halogen, SCN, alkoxy, haloalkoxy, alkenyloxy, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, aminothiocarbonyl, hydroxycarbonyl, alkoxycarbonyl, or aminocarbonyl; B H, OH, NH2, CN, NO2, halogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkenyl, alkenyloxy, alkylthio, haloalkylthio, alkoxythiocarbonylthio, alkoxycarbonylalkoxy, alkoxycarbonylalkylthio, alkylsulfinyl, alkylsulfonyl, aminothiocarbonyl, NR?3R4¿, N=CHOR5, or N=CHNR?5; R3, R4¿ H, alkyl, alkoxycarbonylalkyl, [(alkoxycarbonyl)(alkenyl)]alkyl, alkoxycarbonylalkenyl, alkylcarbonyl, cycloalkylcarbonyl, alkylaminocarbonyl, diaminocarbonyl, alkoxycarbonyl, alkoxyaminosulfonyl, or di(alkoxy)aminosulfonyl; R5 alkyl, haloalkyl, or phenylalkyl; Q H, NO¿2?, halogen, haloalkyl, alkylamino, dialkylamino, alkoxy, haloalkoxy, or alkenyloxy; X H, halogen, haloalkyl, alkoxy or haloalkoxy; Y H, halogen, haloalkyl, alkoxy or haloalkoxy; Z H, halogen, haloalkyl, alkoxy or haloalkoxy; M N or CR?6; R6¿ H, NO¿2?, halogen or haloalkyl; n 0, 1, 2, 3, or 4, with the proviso that, when R?1¿ is hydrogen, n is not zero, processes for the preparation of compounds of formula (I), compositions containing them and their use for the control of insect and acarid pests and for the protection of plants from those pests as well as their use for treating, controlling, preventing and protecting warm-blooded animals and humans against infestation and infection by arachnids and arthropod endo-and ectoparasites.
摘要:
Insecticidal and acaricidal agents containing as the active ingredient pyrazolyl derivatives of general formula (I) and exhibiting excellent controlling effects and high safety. In said formule, A is hydrogen, alkyl, alkenyl, alkynyl, trisubstituted silyl, aryl, or a heterocyclic group; B is a single bond, -(G1)n-G2-(G1)m-, carbonyl, -CH2-O-N=C(R3)-, or -CH=N-O-(CR3R4)n-; R1 is hydrogen, halogeno, alkyl, alkenyl, alkynyl, alkoxy, or aryl; R2 is hydrogen, alkyl, haloalkyl, or aryl; and D is -C(=Y)COX or -N(R5)CO2G5.
摘要:
The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.