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1.发明授权1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS 有权1-芳基-4-取代哌嗪衍生物FOR USE AS CCR1拮抗剂炎症和免疫疾病的治疗
公开(公告)号：EP1531822B1
公开(公告)日：2009-08-05
申请号：EP03737057.4
申请日：2003-06-11
申请人： ChemoCentryx, Inc.
发明人： PENNELL, Andrew, M., K. , AGGEN, James, B. , WRIGHT, J., J., Kim , SEN, Subhabrata , MCMASTER, Brian, E. , DAIRAGHI, Daniel, Joseph , MARTICHONOK, Valeri V.
IPC分类号： A61K31/496 , C07D233/54 , A61P29/00 , C07D257/04 , A61P37/00 , C07D231/16 , C07D249/12 , C07D409/04 , C07D231/38 , C07D231/18 , C07D231/12 , C07D231/14 , C07D231/56 , C07D401/12 , C07D405/04 , C07D473/34 , C07D403/12 , C07D235/06
CPC分类号： C07D473/34 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/56 , C07D235/06 , C07D249/12 , C07D257/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：EP1691810A1
公开(公告)日：2006-08-23
申请号：EP04813774.9
申请日：2004-12-08
申请人： ChemoCentryx, Inc.
发明人： PENNELL, Andrew, M., K. , AGGEN, James, B. , WRIGHT, J., J., Kim , SEN, Subhabrata , MCMASTER, Brian, E. , DAIRAGHI, Daniel, Joseph , CHEN, Wei , ZHANG, Penglie
IPC分类号： A61K31/496 , C07D403/06
CPC分类号： C07D409/04 , C07D231/12 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/61 , C07D235/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D471/04 , C07D473/34
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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3.发明公开1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS 有权1-芳基-4-取代哌嗪衍生物FOR USE AS CCR1拮抗剂炎症和免疫疾病的治疗
公开(公告)号：EP1531822A1
公开(公告)日：2005-05-25
申请号：EP03737057.4
申请日：2003-06-11
申请人： Chemocentryx, Inc.
发明人： PENNELL, Andrew, M., K. , AGGEN, James, B. , WRIGHT, J., J., Kim , SEN, Subrabrata , MCMASTER, Brian, E. , DAIRAGHI, Daniel, Joseph
IPC分类号： A61K31/496 , C07D233/54 , A61P29/00 , C07D257/04 , A61P37/00 , C07D231/16 , C07D249/12 , C07D409/04 , C07D231/38 , C07D231/18 , C07D231/12 , C07D231/14 , C07D231/56 , C07D401/12 , C07D405/04 , C07D473/34 , C07D403/12 , C07D235/06
CPC分类号： C07D473/34 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/38 , C07D231/56 , C07D233/56 , C07D235/06 , C07D249/12 , C07D257/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：EP1720545B1
公开(公告)日：2014-10-29
申请号：EP05724669.6
申请日：2005-03-02
申请人： ChemoCentryx, Inc.
发明人： PENNELL, Andrew, M., K. , AGGEN, James, B. , WRIGHT, J., J., Kim , SEN, Subharata , CHEN, Wei , DAIRAGHI, Daniel, Joseph , ZHANG, Penglie
IPC分类号： A61K31/4155 , C07D403/06 , C07D471/10 , C07D487/04 , C07D487/08
CPC分类号： C07D487/04 , C07D471/10 , C07D487/08
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公开(公告)号：EP1720545A1
公开(公告)日：2006-11-15
申请号：EP05724669.6
申请日：2005-03-02
申请人： ChemoCentryx, Inc.
发明人： PENNELL, Andrew, M., K. , AGGEN, James, B. , WRIGHT, J., J., Kim , SEN, Subharata , CHEN, Wei , DAIRAGHI, Daniel, Joseph , ZHANG, Penglie
IPC分类号： A61K31/4155 , C07D403/06
CPC分类号： C07D487/04 , C07D471/10 , C07D487/08
摘要： Compounds are provided that act as potent modulators of one or more of the CCR1, CCR2 and CCR3 receptors. The compounds are generally fused-, spiro- or bridged-nitrogen heterocycles having an aryl and heteroaryl component and are useful in pharmaceutical compositions, methods for the treatment of CCR1-, CCR2- and/or CCR3-mediated diseases, and as controls in assays for the identification of competitive receptor antagonists for the above chemokine receptors.
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