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    Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
    167.
    发明公开
    Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays 有权
    电子实时细胞识别系统，为Zytotoxizitätsprofil和连接试验应用

    公开(公告)号：EP2639576A1

    公开(公告)日：2013-09-18

    申请号：EP13171137.6

    申请日：2005-02-09

    申请人： Xu, Xiao ,  Abbassi, Yama ,  Wang, Xiaobo

    发明人： Xu, Xiao ,  Abbassi, Yama ,  Wang, Xiaobo

    IPC分类号： G01N27/02 ,  G01N33/487 ,  G01N33/543 ,  C12M1/34

    CPC分类号： C12M25/08 ,  C12M41/36 ,  G01N27/021 ,  G01N33/4836 ,  G01N33/5005

    摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. The methods can be used to test the effects of compounds on cells, such as in cytotoxicity assays. Methods of cytotoxicity profiling of compounds are also provided.