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269 条记录 (耗时 0.023 秒)

    COMPLEXING AGENTS AND TARGETING IMMUNOREAGENTS
    161.
    发明授权
    COMPLEXING AGENTS AND TARGETING IMMUNOREAGENTS 失效
    KOMPLEXBILDNERMITTEL和ZIELIMMUNOREAGENZIEN

    公开(公告)号：EP0639083B1

    公开(公告)日：2001-07-18

    申请号：EP92915130.6

    申请日：1992-05-07

    申请人： NYCOMED IMAGING AS

    发明人： TONER, John, L. ,  HILBORN, David, A. ,  MURRAY, Bruce, J. ,  HOUSSAIN, Timothy, Z. ,  SNOW, Robert, A. ,  SAHA, Ashis, K. ,  PHILION, Richard ,  SHEARMAN, Clyde, W. ,  SHAH, Chandra West Gate Village, 500

    IPC分类号： A61K47/48 ,  A61K51/10

    CPC分类号： C07D213/40 ,  A61K47/6887 ,  A61K49/0002 ,  A61K49/0019 ,  A61K49/0058 ,  A61K51/10 ,  A61K51/1093 ,  A61K2121/00 ,  C07D213/36 ,  C07D213/38 ,  C07D213/42 ,  C07D471/04 ,  C07D471/08

    摘要： A targeting radioactive immunoreagent comprises a metal radionuclide ion, a complexing agent, and an immunoreactive group covalently bonded to said complexing agent, the complexing agent having the structure (AI), wherein R represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R1 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R2 represents hydroxy, carboxy, hydroxyalkyl, thioalkyl, formyl, carbonyliminodiacetic acid, methyleneiminodiacetic acid, methylenethioethyleneiminodiacetic acid, carboxyalkylthioalkyl, hydrazinylidenediacetic acid, or a salt of such acids, or two R2 groups, taken together, represent the atoms necessary to complete a macrocyclic ring structure containing at least one heteroatom coordinating site and at least one, preferably two alkylene groups forming part of the ring structure; R3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R4 represents hydrogen or a protein reactive group; n is 0 to 4; o is 0 or 1; m is 0 or 1; provided that at least one of n and m is 0 and at least one of R, R?1, R3 and R4¿ is a protein reactive group. In another aspect, this invention provides novel terpyridines, quaterpyridines, quinqepyridines, sexipyridines and phenanthrolines having the structure (AI). Preferred terpyridines have the structure (AI) above wherein n=1, o=1, m=0, and R is a protein reactive group or a phenyl substituted with a protein reactive group. Optionally, the phenyl may also contain one or more substituents selected from alkyl and alkoxy. Preferred phenanthrolines have the structure (AI) above wherein n=0, o=1, m=1 and at least one R4 is a protein reactive group. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.

    CONTRAST MEDIA
    163.
    发明公开
    CONTRAST MEDIA 审中-公开
    造影剂

    公开(公告)号：EP1077730A1

    公开(公告)日：2001-02-28

    申请号：EP99921017.2

    申请日：1999-05-11

    申请人： NYCOMED IMAGING AS

    发明人： HENRIKSEN, Ingrid ,  DEG RSTUEN, Liv-Ingrid ,  JACOBSEN, Tove

    IPC分类号： A61K49/00

    CPC分类号： A61K49/222

    摘要： The invention relates to a process for the preparation of a contrast medium which process comprises: i) obtaining a composition comprising a lipid membrane in a high axial ratio conformation; ii) contacting said composition with an agent serving to release the lipid membrane from the high axial ratio conformation; and iii) agitating said composition in the presence of a biotolerable contrast generator or precursor whereby to form contrast generator or precursor containing lipid-membraned vesicles and to contrast media obtained thereby and to methods of imaging utilising said media.

    Ex vivo nuclear polarisation of a magnetic resonance imaging contrast agent by means of ortho-deuterium enriched hydrogen gas
    166.
    发明公开
    Ex vivo nuclear polarisation of a magnetic resonance imaging contrast agent by means of ortho-deuterium enriched hydrogen gas 审中-公开
    的造影剂用于磁共振成像的核的离体偏振装置富含邻 - 氘氢气

    公开(公告)号：EP1058122A2

    公开(公告)日：2000-12-06

    申请号：EP00304101.9

    申请日：2000-05-16

    申请人： NYCOMED IMAGING AS

    发明人： Golman, Klaes Nycomed Innovation AB ,  Axelsson, Oskar Nycomed Innovation AB ,  Johanneson, Haukur Nycomed Innovation AB

    IPC分类号： G01R33/28

    CPC分类号： G01R33/5601 ,  G01R33/56308

    摘要： The present invention provides a method of magnetic resonance investigation of a sample, said method comprising:

    (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent;
    (ii) optionally, subjecting said hydrogenated MR imaging agent to a low magnetic field;
    (iii) administering said hydrogenated MR imaging agent to said sample;
    (iv) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent;
    (v) detecting magnetic resonance signals of said selected non-zero nuclear spin nuclei from said sample; and
    (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.

    摘要翻译： 本发明提供的样品的磁共振研究的方法，所述方法包括：（i）使邻 - 氘富集的氢与可氢化MR成像剂前体，以产生氢化（氘化即）MR成像剂; （ii）任选使所述氢化MR成像剂到低磁场; （三）给予所述氢化MR成像剂与所述样品; （四）使所述样品暴露于选定的以激发选定的非零核自旋的MR成像剂的核，所述氢化的核自旋跃迁的频率的辐射; （V）检测所述的磁共振信号选自所述样品非零核自旋核; 和（ⅵ）任选地，从所述生成的图像或生物功能性数据或动态流数据中检测到的信号。