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公开(公告)号：EP3113772B1
公开(公告)日：2020-09-09
申请号：EP15759254.4
申请日：2015-03-09
发明人： KOTIAN, Pravin L. , BABU, Yarlagadda S. , WU, Minwan , CHINTAREDDY, Venkat R. , KUMAR, Satish V. , ZHANG, Weihe
IPC分类号： C07D403/12 , C07D401/14 , C07D231/14 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/12 , A61P7/02 , A61K31/415
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公开(公告)号：EP3345605A1
公开(公告)日：2018-07-11
申请号：EP17196354.9
申请日：2011-10-14
IPC分类号： A61K31/519 , A61K31/215 , A61K45/06 , A61P31/14 , A61P31/16
摘要： The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and compositions that are useful for treating viral infections in subjects. The methods comprise administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The composition or method may optionally comprise one or more additional antiviral agents.
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公开(公告)号：EP3251674A3
公开(公告)日：2018-02-21
申请号：EP17162146.9
申请日：2013-11-18
IPC分类号： A61K31/505 , C07D401/04 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , C07D401/04 , C07D403/04 , Y02A50/463
摘要： Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.
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公开(公告)号：EP3251674A2
公开(公告)日：2017-12-06
申请号：EP17162146.9
申请日：2013-11-18
IPC分类号： A61K31/505 , C07D401/04 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , C07D401/04 , C07D403/04 , Y02A50/463
摘要： Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.
摘要翻译： 公开了包含与杂环碱基连接的氮杂糖的化合物，包括其药学上可接受的盐，其适用于抑制病毒RNA聚合酶活性或病毒复制，以及治疗病毒感染。 这些化合物的部分特征在于对活性药物成分有利的药代动力学，特别是与肠内给药相结合，特别是包括口服给药。 还公开了包含一种或多种上述化合物或其药学上可接受的盐的药物组合物，以及其制备方法。 还提供了抑制病毒RNA聚合酶活性，病毒复制和治疗病毒感染的方法。
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公开(公告)号：EP2919785A2
公开(公告)日：2015-09-23
申请号：EP13855441.5
申请日：2013-11-18
IPC分类号： A61K31/505
CPC分类号： C07D487/04 , A61K31/519 , C07D401/04 , C07D403/04 , Y02A50/463
摘要： Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.
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16.发明授权SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS 有权CYPOPENTETE CYCLOPENTAN- UND CYCLOPENTEN-VERBINDUNGEN ALS NEURAMINIDASE-BLOCKER
公开(公告)号：EP1040094B9
公开(公告)日：2015-09-09
申请号：EP98966003.0
申请日：1998-12-17
IPC分类号： C07C69/74 , C07C61/06 , C07C61/20 , C07C49/105 , C07C49/297 , C07C49/395 , C07C49/597 , C07D261/20 , C07D233/54 , C07D341/00
CPC分类号： C07D231/12 , C07C229/48 , C07C233/47 , C07C247/14 , C07C271/24 , C07C279/16 , C07C279/24 , C07C309/66 , C07C323/59 , C07C323/60 , C07C2601/08 , C07C2601/10 , C07D233/56 , C07D249/08 , C07D261/20 , C07D339/08
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17.发明授权COMPOSITIONS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS 有权ZUSAMMENSETZUNGEN ZUR VERWENDUNG BEI DER BEHANDLUNG VON VIRALEN INFEKTIONEN
公开(公告)号：EP2627334B1
公开(公告)日：2015-04-29
申请号：EP11833515.7
申请日：2011-10-14
IPC分类号： A61K31/519 , A61K31/215 , A61K45/06 , A61P31/14
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/7064 , A61K45/06 , A61P31/14 , A61P31/16 , C07D487/04 , C07H7/06 , Y02A50/385 , Y02A50/393 , Y02A50/397 , A61K2300/00
摘要： The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and compositions that are useful for treating viral infections in subjects. The methods comprise administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The composition or method may optionally comprise one or more additional anti-viral agents.
摘要翻译： 本发明涉及用于抑制病毒核酸聚合酶（例如RNA和DNA聚合酶）的方法和组合物，以及可用于治疗受试者的病毒感染的方法和组合物。 所述方法包括向受试者施用治疗有效量的式I化合物或其药学上可接受的盐或水合物，或包含式I化合物或其药学上可接受的盐或水合物的组合物和药学上可接受的 载体。 组合物或方法可任选地包含一种或多种另外的抗病毒剂。
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公开(公告)号：EP2535345A1
公开(公告)日：2012-12-19
申请号：EP12168831.1
申请日：2008-01-11
IPC分类号： C07H19/23 , A61K31/706 , A61P31/12 , A61P35/00
CPC分类号： C07H19/23
摘要： The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译： 本发明提供如本文所述的式（I）化合物以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。 式（I）的化合物可用作抗病毒剂和/或作为抗癌剂。
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19.发明公开TETRAHYDROFURO Ý3 4-D¨DIOXOLANE COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND CANCER 有权四氢[3,4-D]二氧戊环FOR USE IN病毒感染和癌症的治疗
公开(公告)号：EP2155758A1
公开(公告)日：2010-02-24
申请号：EP08747850.9
申请日：2008-05-08
IPC分类号： C07D519/00 , A61K31/519 , A61P35/00 , A61P31/12
CPC分类号： C07D519/00
摘要： The invention provides compounds of formula (I), as described herein, or pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
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公开(公告)号：EP2114980A2
公开(公告)日：2009-11-11
申请号：EP08727625.9
申请日：2008-01-11
IPC分类号： C07H19/23 , A61K31/706 , A61P31/12 , A61P35/00
CPC分类号： C07H19/23
摘要： The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
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