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1.发明公开TETRAHYDROFURO Ý3 4-D¨DIOXOLANE COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND CANCER 有权四氢[3,4-D]二氧戊环FOR USE IN病毒感染和癌症的治疗
公开(公告)号：EP2155758A1
公开(公告)日：2010-02-24
申请号：EP08747850.9
申请日：2008-05-08
IPC分类号： C07D519/00 , A61K31/519 , A61P35/00 , A61P31/12
CPC分类号： C07D519/00
摘要： The invention provides compounds of formula (I), as described herein, or pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
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公开(公告)号：EP1814561A2
公开(公告)日：2007-08-08
申请号：EP05820258.1
申请日：2005-10-28
发明人： BABU, Yarlagadda S. , CHAND, Pooran , WU, Minwan , KOTIAN, Pravin L. , KUMAR, V., Satish , LIN, Tsu-hsing , EL-KATTAN, Yahya , GHOSH, Ajit, K. , HARRIS, Robert J.
IPC分类号： A61K31/7076
CPC分类号： C07D495/04 , A61K31/675 , A61K31/7076 , A61K38/212 , A61K38/2292 , C07D491/048 , C07D493/04 , C07F9/6561 , C07H7/06 , C07H19/22 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.
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公开(公告)号：EP1383731A1
公开(公告)日：2004-01-28
申请号：EP01981772.5
申请日：2001-10-22
发明人： BABU, Yarlagadda, S. , ROWLAND, Scott, R. , CHAND, Pooran , KOTIAN, Pravin, L. , EL-KATTAN, Yahya , NIWAS, Shri
IPC分类号： C07C229/38 , C07C317/22 , C07C63/04 , C07C257/00 , C07D333/22 , C07D307/02 , C07D277/30 , C07D207/30 , C07D207/08 , C07D211/70 , C07D311/78 , C07D239/02 , C07D265/30 , C07D277/62
CPC分类号： C07D209/08 , A61K31/192 , A61K31/341 , A61K31/381 , A61K31/426 , A61K31/4418 , C07C229/38 , C07C233/54 , C07C235/84 , C07C251/48 , C07C255/57 , C07C255/58 , C07C257/18 , C07C259/18 , C07C259/20 , C07C271/22 , C07C271/64 , C07C309/65 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/337 , C07D213/40 , C07D213/56 , C07D213/74 , C07D213/75 , C07D213/78 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/56 , C07D233/56 , C07D233/64 , C07D235/14 , C07D235/30 , C07D235/32 , C07D239/14 , C07D239/42 , C07D239/48 , C07D249/08 , C07D277/30 , C07D277/82 , C07D307/54 , C07D311/80 , C07D317/46 , C07D317/68 , C07D333/24 , C07D333/38
摘要： Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents.
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4.发明公开PREPARATION OF SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS AND CERTAIN INTERMEDIATES 审中-公开制备取代的环戊烷和环戊烯的化合物和一些中间体
公开(公告)号：EP1189862A1
公开(公告)日：2002-03-27
申请号：EP00946871.1
申请日：2000-06-28
发明人： CHAND, Pooran , ELLIOTT, Arthur, J.
IPC分类号： C07C61/06 , C07C62/18 , C07C205/55 , C07C229/28 , C07D261/20
CPC分类号： C07D261/20 , C07C17/10 , C07C231/00 , C07C271/24 , C07C279/16 , C07C279/24 , C07C2601/08 , C07C2601/10 , C07C19/075 , C07C233/48
摘要： The invention relates to methods for preparing substituted cyclopentene compounds, their intermediates and use as neuraminidase inhibitors.
摘要翻译： 本发明涉及一种用于制备substituiertem环戊烯化合物，中间体和它们作为神经氨酸酶抑制剂的用途的方法。
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5.发明授权SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS 有权CYPOPENTETE CYCLOPENTAN- UND CYCLOPENTEN-VERBINDUNGEN ALS NEURAMINIDASE-BLOCKER
公开(公告)号：EP1040094B9
公开(公告)日：2015-09-09
申请号：EP98966003.0
申请日：1998-12-17
IPC分类号： C07C69/74 , C07C61/06 , C07C61/20 , C07C49/105 , C07C49/297 , C07C49/395 , C07C49/597 , C07D261/20 , C07D233/54 , C07D341/00
CPC分类号： C07D231/12 , C07C229/48 , C07C233/47 , C07C247/14 , C07C271/24 , C07C279/16 , C07C279/24 , C07C309/66 , C07C323/59 , C07C323/60 , C07C2601/08 , C07C2601/10 , C07D233/56 , C07D249/08 , C07D261/20 , C07D339/08
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公开(公告)号：EP2114980A2
公开(公告)日：2009-11-11
申请号：EP08727625.9
申请日：2008-01-11
IPC分类号： C07H19/23 , A61K31/706 , A61P31/12 , A61P35/00
CPC分类号： C07H19/23
摘要： The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
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7.发明授权
公开(公告)号：EP1383731B1
公开(公告)日：2009-08-05
申请号：EP01981772.5
申请日：2001-10-22
发明人： BABU, Yarlagadda, S. , ROWLAND, Scott, R. , CHAND, Pooran , KOTIAN, Pravin, L. , EL-KATTAN, Yahya , NIWAS, Shri
IPC分类号： C07C229/38 , C07C317/22 , C07C63/04 , C07C257/00 , C07D333/22 , C07D307/02 , C07D277/30 , C07D207/30 , C07D207/08 , C07D211/70 , C07D311/78 , A61K31/192 , A61K31/341 , A61P7/00
CPC分类号： C07D209/08 , A61K31/192 , A61K31/341 , A61K31/381 , A61K31/426 , A61K31/4418 , C07C229/38 , C07C233/54 , C07C235/84 , C07C251/48 , C07C255/57 , C07C255/58 , C07C257/18 , C07C259/18 , C07C259/20 , C07C271/22 , C07C271/64 , C07C309/65 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/337 , C07D213/40 , C07D213/56 , C07D213/74 , C07D213/75 , C07D213/78 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/56 , C07D233/56 , C07D233/64 , C07D235/14 , C07D235/30 , C07D235/32 , C07D239/14 , C07D239/42 , C07D239/48 , C07D249/08 , C07D277/30 , C07D277/82 , C07D307/54 , C07D311/80 , C07D317/46 , C07D317/68 , C07D333/24 , C07D333/38
摘要： Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents.
摘要翻译： 式（I）化合物可用作胰蛋白酶样丝氨酸蛋白酶如凝血酶，因子VIIa，因子Xa，TF / FVIIa和胰蛋白酶的抑制剂。 这些化合物可用于治疗和/或预防凝血障碍，以及作为抗凝剂。
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公开(公告)号：EP2324020A2
公开(公告)日：2011-05-25
申请号：EP09791064.0
申请日：2009-07-31
IPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04 , A61P37/06 , A61K31/53
CPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04
摘要： The invention provides a compound of formula (I): wherein R
1 , and W have any of the values defined in the application; or a salt thereof. The compounds and salts thereof have beneficial therapeutic properties (e.g. immunosuppressant properties).-
9.发明授权SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS 有权取代环戊烷和环戊烯化合物作为神经氨酸酶受体阻滞剂
公开(公告)号：EP1040094B1
公开(公告)日：2009-03-18
申请号：EP98966003.0
申请日：1998-12-17
IPC分类号： C07C69/74 , C07C61/06 , C07C61/20 , C07C49/105 , C07C49/297 , C07C49/395 , C07C49/597 , C07D261/20 , C07D233/54 , C07D341/00
CPC分类号： C07D231/12 , C07C229/48 , C07C233/47 , C07C247/14 , C07C271/24 , C07C279/16 , C07C279/24 , C07C309/66 , C07C323/59 , C07C323/60 , C07C2601/08 , C07C2601/10 , C07D233/56 , C07D249/08 , C07D261/20 , C07D339/08
摘要： Compounds represented by formulae (I, II or III), wherein U is CH, O, or S; Z is -C(R2)(R3), -CH-N(R2)(R3), C(R3)[(CH2)nR2], CH-C(R3)(R8)(CH2)nR2, C[(CH2)nR2]-[CH(R3)(R8)], C[(R3)][CH[(CH2)nR2](R8)]; R1 is H, (CH2)nOH, (CH2)nNH2, (CH2)nNR10R11, (CH2)nOR11, (CH2)nSR11, or (CH2)n halogen; R9 is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters thereof, or salts thereof.
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公开(公告)号：EP0933993A1
公开(公告)日：1999-08-11
申请号：EP97931014.0
申请日：1997-06-13
IPC分类号： C07D295 , A01N37 , A01N47 , A61K31 , A61P31 , C07C61 , C07C62 , C07C69 , C07C233 , C07C237 , C07C279 , C07D205 , C07D211
CPC分类号： C07D295/185 , C07C61/06 , C07C62/02 , C07C69/757 , C07C233/47 , C07C279/14 , C07C279/16 , C07C2601/08 , C07D205/04
摘要： Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase inhibitors and can be used in treating patients infected with influenza virus.
摘要翻译： 由式（I）表示的化合物及其药学上可接受的盐; 并提供了它们的制备方法。 上述化合物是流感病毒神经氨酸酶抑制剂，可用于治疗感染流感病毒的患者。
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