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公开(公告)号：EP0965355B1
公开(公告)日：2005-05-04
申请号：EP99101672.6
申请日：1999-02-05
CPC分类号： A61M15/0086 , A61M15/0088
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12.发明授权Therapeutic composition of non MHC-restricted T-cells/NK-cells and MHC-restricted cells for the treatment of tumors 有权包含非MHC依赖性T细胞/ NK细胞和MHC依赖性细胞肿瘤的治疗的药物组合物
公开(公告)号：EP1275400B1
公开(公告)日：2004-11-03
申请号：EP02015101.5
申请日：2002-07-05
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公开(公告)号：EP0892852B1
公开(公告)日：2004-09-08
申请号：EP97919307.5
申请日：1997-03-27
摘要： A replication-defective retroviral vector carrying a cytochrome P450 gene under transcriptional control of target cell specific regulatory elements or promoters, or X-ray inducible promoters.
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14.发明公开REKOMBINANTES MVA MIT DER FÄHIGKEIT ZUR EXPRESSION VON HCV STRUKTUR-ANTIGENEN 有权符合表达结构HCV抗原的能力重组MVA
公开(公告)号：EP1423525A1
公开(公告)日：2004-06-02
申请号：EP02797955.8
申请日：2002-09-05
发明人： SUTTER, Gerd , ERFLE, Volker , STAIB, Caroline , WANG, Yuan, , LI, Guangdi, , ZHU, Lixin,
IPC分类号： C12N15/863 , C12N15/39 , C12N15/51 , C12N5/10 , A61K39/285 , A61K39/29
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C12N15/86 , C12N2710/24143 , C12N2770/24234 , C12N2770/24243
摘要： The invention relates to recombinant MVA which is capable of expressing structural HCV antigens, functional parts of said structural antigens or epitopes of said structural antigens. The invention further relates to a pharmaceutical composition, especially in the form of a vaccine and containing the recombinant MVA according to the invention, to eukaryotic cells that contain the inventive recombinant MVA and to various uses of the recombinant MVA, for example for producing recombinant structural proteins, for producing a pharmaceutical preparation that is suitable for the therapy and prophylaxis of HCV infections and diseases thereby caused. The invention further relates to methods for producing recombinant MVA and recombinant structural HCV polypeptides encoded by said recombinant MVA, and to DNA or RNA of said recombinant MVA.
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公开(公告)号：EP1392723A2
公开(公告)日：2004-03-03
申请号：EP02706731.3
申请日：2002-02-01
申请人： GSF Forschungszentrum für Umwelt und Gesundheit GMBH , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
CPC分类号： C07K14/4702 , A61K35/12 , A61K48/00 , A61K2039/505 , C12N5/0619 , C12N2501/60 , G01N33/6896
摘要： This invention relates to a novel DNA sequence encoding a bHLH transcription factor in vertebrates, preferably mammals, e.g. in mice or humans, as well as the expressed transcription factor. The invention further relates to vectors containing said DNA sequences and host cells transformed by these vectors. Furthermore, the invention encompasses antibodies specific for the transcription factors as well as the use of the DNA sequences and transcription factors in the diagnosis or therapy of neurodegenerative diseases, e.g. Parkinson's disease. The present invention further relates to an ex vivo method of producing dopaminergic cells and the therapeutic use of these dopaminergic cells.
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16.发明授权
公开(公告)号：EP1242834B1
公开(公告)日：2004-01-21
申请号：EP00916862.6
申请日：2000-02-24
CPC分类号： G01N33/24 , G01N1/02 , G01N33/0057 , G01N2001/2826
摘要： The invention relates to a method for detecting trace substances and/or environmental properties. The aim of the invention is to enable a rapid analysis which is resolved by position. This is achieved by laying out a collecting medium of any cross-section, which is extended in at least one dimension, according to a selectable local grid; by retrieving the collecting medium after an adequate period of interaction with the environment, e.g. with water, air or the ground and by analysing the collecting medium using a position resolution and establishing a correlation with the local grid of the laid-out medium.
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17.发明公开
公开(公告)号：EP0911388A3
公开(公告)日：2003-11-26
申请号：EP98111599.1
申请日：1998-06-24
发明人： Staege, Martin S., Dr. , Kempkes, Bettina, Dr. , Bornkamm, Georg W., Prof. Dr. , Hammerschmidt, Wolfgang, Dr. , Zimber-Strobl, Ursula, Dr. , Polack, Axel, Dr.
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N2501/52 , C12N2502/11 , C12N2510/04
摘要： Die Erfindung beschreibt Verfahren zur Stimulation von T-Zellen mit gewünschter Antigenspezifität, wobei ein bevorzugtes Verfahren die nachfolgenden Schritte aufweist: (a) Einführen von Immortalisierungs-Genen in antigenpräsentierende Zellen (APC) in solcher Weise, daß zumindest die Expression und/oder Funktion zumindest eines dieser Gene regulierbar ist, um konditional immortalisierte antigenpräsentierende Zellen zu erhalten; (b) Einführen eines für das gewünschte Antigen kodierenden Gens in die im Schritt (a) erhaltenen immortalisierten Zellen in solcher Weise, daß das Antigen zumindest auch nach dem Stop der Expression und/oder der Aufhebung der Funktion zumindest eines der Immortalisierungsgene exprimierbar ist; (c) Expansion der immortalisierten antigenpräsentierenden Zellen durch Expression der Immortalisierungsgene und/oder durch funktionelle Aktivierung der Immortalisierungsgene; (d) Beendigung der Proliferation der immortalisierten antigenpräsentierenden Zellen durch Stop der Expression und/oder durch Aufhebung der Funktion zumindest eines der regulierbaren Immortalisierungsgene; (e) fortgesetzte Expression des Antigens; (f) Zugabe leukozytärer Zellen, die zumindest T-Zellen enthalten, und Kultivierung des Zellgemisches zur Stimulation der gegen das gewünschte Antigen gerichteten T-Zellen; (g) wahlweise Aufreinigung und Isolierung der stimulierten T-Zellen.
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18.发明授权VORRICHTUNG ZUR UNTERSUCHUNG VON UMWELTCHEMIKALIEN IN BÖDEN MITTELS EINES DYNAMISCHEN LABOR-TESTSYSTEMS 有权设备提供了环境化学物质的土壤研究使用动态实验室测试系统
公开(公告)号：EP1166104B1
公开(公告)日：2003-07-09
申请号：EP00906261.3
申请日：2000-02-01
发明人： SCHROLL, Reiner
CPC分类号： G01N33/246
摘要： The invention relates to a device for investigating the behaviour and the degradation of environmental chemicals in a dynamic system. Said device comprises at least one container, which is filled with a disturbed or undisturbed soil; a rain device which is arranged above the soil surface, a ventilator device which produces an even wind motion above the soil surface, and a vacuum system for regulating a predetermined groundwater table inside the soil. The inventive laboratory testing system ("microcosm arrangement") makes it possible to determine the transport, transformation, mineralisation and volatilisation of chemicals in natural climate conditions without the influence of plants and under the influence of plants in disturbed and undisturbed plate columns. The invention also relates to a method for testing chemicals in soils using the inventive device.
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公开(公告)号：EP0995132B1
公开(公告)日：2003-05-02
申请号：EP98937550.6
申请日：1998-06-26
CPC分类号： G01T1/2928 , G01T1/026 , G01T1/17 , G01T1/36
摘要： The invention relates to a method for detecting photon spectra using at least two semiconductor detectors, at least one of said semiconductor detectors being covered with a metal filter. The aim of the invention is to provide a method enabling the radiation dosage to be detected throughout the relevant energy range in real time. To this end, the integral counting rates of the semiconductor detectors are used as input values for the ANN (artificial neural network) -compatible topology, said topology having been trained for this problem definition, and a photon spectrum is allocated to said input values by said ANN.
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20.发明公开NUKLEOTID- UND AMINOSAURESEQUENZEN EINES ZELLULAREN REPRESSORS DER DNA REPLIKATION DES HERPES-VIRUS EPSTEIN-BAR 审中-公开核苷酸和氨基酸序列疱疹病毒爱泼斯坦 - BAR DNA复制的蜂窝状阻遏
公开(公告)号：EP1297126A1
公开(公告)日：2003-04-02
申请号：EP00949265.3
申请日：2000-07-05
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention relates to the identification of a cellular inhibitor of DNA replication in the Epstein-Barr herpes virus (EPV), called TB7. The invention further relates to the discovery of the nucleotide and amino acid sequences of TB7 and the use of TB7, in particular for the production of a pharmaceutical preparation for suppression of the multiplication of EBV in infected patients.
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