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11.发明公开
公开(公告)号：EP3452063A1
公开(公告)日：2019-03-13
申请号：EP17796602.5
申请日：2017-05-05
申请人： Celularity, Inc.
发明人： FISCHKOFF, Steven, Alan , HERZBERG, Uri , KANG, Lin , MURPHY, Brian , NORDBERG, Andrea , VOSKINARIAN-BERSE, Vanessa , WILSON, Keith , ZHANG, Xiaokui , MYINT, Han , HUSSEIN, Mohamed
IPC分类号： A61K35/17 , A61P35/00 , C12N5/0783
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公开(公告)号：EP3172963B1
公开(公告)日：2019-02-06
申请号：EP16190626.8
申请日：2009-08-20
申请人： Celularity, Inc.
发明人： ZEITLIN, Andy , RUSSOTTI, Gregory , HE, Shuyang , PAL, Ajai , CHEN, Hong, J. , BRIEVA, Thomas , SHORR, Ryan , MURPHY, Brian
IPC分类号： A01N1/02
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公开(公告)号：EP2714059B1
公开(公告)日：2018-10-03
申请号：EP12792203.7
申请日：2012-05-31
申请人： Celularity, Inc.
发明人： HERZBERG, Uri , GURNEY, Jodi
CPC分类号： A61K35/50 , C12N5/0605 , C12N5/0668
摘要： Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).
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公开(公告)号：EP2968420B1
公开(公告)日：2018-09-05
申请号：EP14775592.0
申请日：2014-03-13
申请人： Celularity, Inc.
CPC分类号： A61K35/50
摘要： Provided herein are methods of using human placental stem cells in the treatment of subjects having acute kidney injury (AKI).
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公开(公告)号：EP3362075A1
公开(公告)日：2018-08-22
申请号：EP16856249.4
申请日：2016-10-14
申请人： CELULARITY, INC.
发明人： ZHANG, Xiaokui , DJURETIC, Ivana , KANG, Lin , VOSKINARIAN-BERSE, Vanessa , STOUT, Bhavani , HARIRI, Robert J. , HOFGARTNER, Wolfgang , EDINGER, James , LAW, Eric , JANKOVIC, Vladimir
IPC分类号： A61K35/17 , A61P35/00 , C12N5/0783
CPC分类号： C12N5/0646 , A61K35/17 , C12N5/0634 , C12N2501/125 , C12N2501/22 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/30 , C12N2501/999 , C12N2506/03
摘要： Provided herein are methods of producing natural killer (NK) cells and/or ILC3 cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein to an individual having the cancer or viral infection.
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公开(公告)号：EP4094578A1
公开(公告)日：2022-11-30
申请号：EP22167210.8
申请日：2007-05-11
申请人： Celularity Inc.
发明人： Naoko, Takebe
IPC分类号： A01N1/02
摘要： An innovative method of collecting cord blood stern cells from an isolated mammalian non-exsanguinated or partially exsanguinated placenta by placental perfusion is described. Placental perfusion can include perfusing the isolated placenta with a pulsatile flow of perfusion solution, for example, using a pulsatile or peristaltic pump or device. The stem cells can then be isolated from the perfusate. The perfusion solution can include an anticoagulant. The isolated mammalian placenta need not be treated with an anticoagulant prior to perfusing. The isolated placenta can be free from an anticoagulant prior to perfusing.
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公开(公告)号：EP3887364A1
公开(公告)日：2021-10-06
申请号：EP19827981.2
申请日：2019-11-29
申请人： Celularity Inc.
IPC分类号： C07D401/14 , C07D409/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61P43/00 , A61K31/506 , A61K31/519 , A61K31/4985
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公开(公告)号：EP3622960A1
公开(公告)日：2020-03-18
申请号：EP19185231.8
申请日：2014-02-04
申请人： Celularity, Inc.
发明人： ZHANG, Xiaokui , HARIRI, Robert J. , VOSKINARIAN-BERSE, Vanessa , KANG, Lin , LAW, Eric , ABBOT, Stewart
IPC分类号： A61K35/17 , A61K35/50 , A61P37/08 , A61K31/454
摘要： Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killers cells, and combined natural killer cells and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells. Also provided herein are methods of treating an individual having a tumor or graft-versus-host disease with placental perfusate, placental perfusate-derived cells, natural killer cells from placenta, e.g. from placental perfusate, and/or combined natural killer cells comprising natural killer cells from placenta, e.g., from placental perfusate, and umbilical cord blood.
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公开(公告)号：EP3486314A3
公开(公告)日：2019-08-07
申请号：EP18196002.2
申请日：2006-12-28
申请人： Celularity, Inc.
发明人： ABRAMSON, Sascha D. , EDINGER, James W. , FALECK, Herbert , HARIRI, Robert, J. , LABAZZO, Kristen S. , PEREIRA, Marian , WANG, Jia-Lun , YE, Qian
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
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公开(公告)号：EP3486314A2
公开(公告)日：2019-05-22
申请号：EP18196002.2
申请日：2006-12-28
申请人： Celularity, Inc.
发明人： ABRAMSON, Sascha D. , EDINGER, James W. , FALECK, Herbert , HARIRI, Robert, J. , LABAZZO, Kristen S. , PEREIRA, Marian , WANG, Jia-Lun , YE, Qian
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
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