公开(公告)号：EP2283121A2

公开(公告)日：2011-02-16

申请号：EP09747777.2

申请日：2009-05-18

申请人： LS9, Inc.

发明人： SCHIRMER, Andreas ,  RUDE, Mathew ,  BRUBAKER, Shane

IPC分类号： C12N9/04 ,  C12P7/24 ,  C12N15/53 ,  C12P7/04

CPC分类号： C12P7/64 ,  C10L1/02 ,  C10L2200/0469 ,  C10L2290/26 ,  C12N9/0004 ,  C12N9/0008 ,  C12N9/88 ,  C12P5/02 ,  C12P5/026 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409 ,  C12P7/6436 ,  C12P7/649 ,  C12Y102/0108 ,  C12Y401/99005 ,  Y02E50/13 ,  Y02P20/52 ,  Y02T50/678

摘要： Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.

公开(公告)号：EP2840131A3

公开(公告)日：2015-04-08

申请号：EP14193614.6

申请日：2007-05-18

申请人： LS9, Inc.

发明人： Keasling, Jay D. ,  Hu, Zhihao ,  Somerville, Chris ,  Church, George ,  Berry, David ,  Friedman, Lisa ,  Schirmer, Andreas ,  Brubaker, Shane ,  Del Cardayre, Stephen B.

IPC分类号： C12N1/20 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12P7/04 ,  C12P7/64 ,  C10L1/08 ,  C10L1/10 ,  C12N9/00

摘要： Genetically engineered microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use.

摘要翻译： 提供从脂肪酸生物合成途径（脂肪酸衍生物）产生产物的基因工程微生物以及它们的使用方法。

公开(公告)号：EP2840131A2

公开(公告)日：2015-02-25

申请号：EP14193614.6

申请日：2007-05-18

申请人： LS9, Inc.

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N1/20 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12P7/04 ,  C12P7/64 ,  C10L1/08 ,  C10L1/10

摘要： Genetically engineered microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use.

公开(公告)号：EP2663636A1

公开(公告)日：2013-11-20

申请号：EP11722657.1

申请日：2011-05-10

申请人： Ls9, Inc.

发明人： HU, Zhihao ,  LEE, Grace, J. ,  SCHIRMER, Andreas ,  ZAKHARYEVICH, Kseniya ,  GREENFIELD, Derek, L. ,  BARON, Tarah, S. ,  HOLDEN, Kevin

IPC分类号： C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N15/52 ,  C12P7/64

CPC分类号： C12N9/1029 ,  C12N9/0008 ,  C12N15/52 ,  C12P7/64

摘要： Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.

摘要翻译： 重组微生物的细胞提供已工程化以产生支链产品：如由脂肪酸生物合成途径分支的脂肪酸衍生物，以及制备使用所述重组微生物细胞支链脂肪酸衍生物的方法。

公开(公告)号：EP2367947A4

公开(公告)日：2012-10-24

申请号：EP09829536

申请日：2009-10-07

申请人： LS9 INC

发明人： HU ZHIHAO

IPC分类号： C12P7/04

CPC分类号： C12P7/64 ,  A61K31/045 ,  C12N1/20 ,  C12N9/0004 ,  C12N2501/71 ,  C12N2502/99 ,  C12P7/04 ,  C12R1/01

摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.

公开(公告)号：EP2425007A1

公开(公告)日：2012-03-07

申请号：EP10770203.7

申请日：2010-04-27

申请人： Ls9, Inc.

发明人： SANCHEZ-RIERA, Fernando ,  DEL CARDAYRE, Stephen, B. ,  VALLE, Fernando

IPC分类号： C12P7/64

CPC分类号： C12P7/649 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/52 ,  C12P7/065 ,  Y02E50/13 ,  Y02E50/17

摘要： Methods of producing fatty acid esters, such as fatty acid ethyl esters, from microorganisms genetically engineered to alter the expression of genes involved in fatty acid synthesis and/or ethanol production, such that a microorganism is obtained that can produce an alcohol, a fatty acid and an ester synthase in the absence of exogenously added alcohols.

公开(公告)号：EP2417244A1

公开(公告)日：2012-02-15

申请号：EP10762558.4

申请日：2010-04-10

申请人： LS9, Inc.

发明人： SANCHEZ-RIERA, Fernando ,  HUANG, Wei ,  SHASTRY, Vineet

IPC分类号： C12N1/00 ,  C12N1/21

CPC分类号： C10L1/026 ,  C10L2200/0476 ,  C10L2270/026 ,  C10L2290/26 ,  C12P7/649 ,  Y02E50/13 ,  Y02P30/20

摘要： The invention provides a fermentation and recovery process for the production of biodiesel of commercial grade quality according to commercial and environmental standards (e.g., ASTM ANP, or EPA trace elements and emissions standards), by fermentation of carbohydrates using a genetically modified microorganism. The process provides a direct route for the production of fatty esters, without the need for producing oils which are later chemically transesterified with the concomitant production of large quantities of glycerin and other undesirable side -products.

公开(公告)号：EP2382285A2

公开(公告)日：2011-11-02

申请号：EP09803969.6

申请日：2009-12-23

申请人： LS9, Inc.

发明人： HOM Louis ,  TRINH Na ,  ALIBHAI Murtaza

IPC分类号： C10L1/02 ,  C12N9/16

CPC分类号： C12N9/18 ,  C07H21/04 ,  C10L1/02 ,  C12N9/16 ,  C12N15/00 ,  C12N15/63 ,  C12P21/06

摘要： The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

摘要翻译： 本发明涉及新的突变硫酯酶及其天然存在的等同物，由这些酶制成的组合物和硫酯酶的用途。 特别地，本发明提供突变体硫酯酶，其具有改变的性质，例如，改变的底物特异性，改变的活性，改变的选择性和/或产物混合物中比例产率的改变。 本发明还提供编码这种突变体硫酯酶的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明进一步提供硫酯酶在生产各种脂肪酸衍生物中的新用途，其可用作工业化学品和燃料的组分。

公开(公告)号：EP2288694A1

公开(公告)日：2011-03-02

申请号：EP09747776.4

申请日：2009-05-18

申请人： LS9, Inc.

发明人： SCHIRMER, Andreas ,  RUE, Mathew ,  BRUBAKER, Shane

IPC分类号： C12N9/02 ,  C12N9/88 ,  C12P7/64 ,  C10L1/02

CPC分类号： C12P7/64 ,  C10L1/02 ,  C10L2200/0469 ,  C10L2290/26 ,  C12N9/0004 ,  C12N9/0008 ,  C12N9/88 ,  C12P5/02 ,  C12P5/026 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409 ,  C12P7/6436 ,  C12P7/649 ,  C12Y102/0108 ,  C12Y401/99005 ,  Y02E50/13 ,  Y02P20/52 ,  Y02T50/678

摘要： Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.

摘要翻译： 本文描述了用于生产醛，烷烃和烯烃的组合物和方法。 醛，烷烃和烯烃可用于生物燃料。

公开(公告)号：EP2194119A3

公开(公告)日：2010-09-22

申请号：EP09013650.8

申请日：2007-05-18

申请人： LS9, Inc.

发明人： Keasling, Jay D. ,  Hu, Zhihao ,  Somerville, Chris ,  Church, George ,  Berry, David ,  Friedman, Lisa ,  Schirmer, Andreas ,  Brubaker, Shane ,  Del Cardayre, Stephen B.

IPC分类号： C12N1/20 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12P7/04 ,  C12P7/64 ,  C10L1/08 ,  C10L1/10

CPC分类号： C12N15/52 ,  C10L1/02 ,  C10L1/026 ,  Y02E50/13

摘要： Genetically engineered microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use.