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公开(公告)号：EP4205735A1
公开(公告)日：2023-07-05
申请号：EP23157390.8
申请日：2016-04-19
IPC分类号： A61K31/198 , A61K31/192 , A61K31/195 , A61P1/16 , C07C57/32
摘要： Some embodiments of the present application are directed to oral formulations of L-ornithine phenylacetate and methods of preparing the same. These oral formulations offer alternative administration route than the standard intravenous administration of L-ornithine phenylacetate for treating hyperammonemia in patients having various acute and chronic liver diseases and disorders, for example, acute liver failure, liver cirrhosis, liver decompensation, portal hypertension, hepatic encephalopathy, or patients with urea cycle disorders.
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公开(公告)号：EP4045028A1
公开(公告)日：2022-08-24
申请号：EP20877445.5
申请日：2020-10-15
发明人： WANG REARS, Xiaofeng , TSENG, Jack , MAK, Carmen , POOLA, Nagaraju , VILCHEZ, Regis , POTNIS, Aniruddha , VANMETER, Susan , STANGE, Jan
IPC分类号： A61K31/198 , A61K31/192 , A61P1/16 , A61P7/00
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公开(公告)号：EP3965659A1
公开(公告)日：2022-03-16
申请号：EP20802314.3
申请日：2020-05-07
发明人： BUKOFZER, Stanley , VILCHEZ, Regis
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公开(公告)号：EP2316846B1
公开(公告)日：2019-10-02
申请号：EP10011035.2
申请日：2004-08-02
发明人： Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Beaubien, Sylvie , Peterson, Mark L. , Ramaseshan, Mahesh , Hoveyda, Hamid R.
IPC分类号： C07K5/00 , C07K5/08 , C07K1/04 , C07K5/12 , C07D263/32 , C07D277/24 , C07D277/28 , C07K5/087 , C07K5/083 , C07K5/097
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公开(公告)号：EP3373923A1
公开(公告)日：2018-09-19
申请号：EP16865158.6
申请日：2016-11-11
发明人： WANG, Laurene , GRAIS, Linda S. , BUKOFZER, Stan
IPC分类号： A61K31/198 , A61K31/192 , A61K31/195 , C07C57/32 , A61K9/00 , A61P3/00 , A61P1/16
CPC分类号： A61K9/5078 , A61K9/5031 , A61K9/5042 , A61K31/198
摘要： Some embodiments of the present application are directed to oral formulations of L- ornithine phenylacetate and methods of using the same. These oral formulations offer alternative administration route than the standard intravenous administration of L-ornithine phenylacetate for treating hyperammonemia in patients having various acute and chronic liver diseases and disorders, for example, acute liver failure, liver cirrhosis, liver decompensation, portal hypertension, hepatic encephalopathy, or patients with urea cycle disorders.
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16.发明公开
公开(公告)号：EP3337473A1
公开(公告)日：2018-06-27
申请号：EP16837708.3
申请日：2016-08-16
IPC分类号： A61K31/192 , A61K31/198 , A61P1/16
CPC分类号： A61K31/198 , A61K9/0019 , A61K31/192 , A61K2300/00 , A61P1/16 , C12Q1/42 , C12Q1/48 , G01N2800/085
摘要： Disclosed herein are methods of treating and preventing muscle loss using ornithine in combination with at least one of phenyl acetate and phenylbutyrate.
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17.发明公开USE OF ADSORBENT CARBON MICROSPHERES FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME 审中-公开使用吸附碳微若要可爱易激综合症的治疗
公开(公告)号：EP1957090A1
公开(公告)日：2008-08-20
申请号：EP06839125.9
申请日：2006-12-05
发明人： SHIBATA, Akiko , FISCHER, Laurent
摘要： Adsorbent carbon microspheres are administered to treat irritable bowel syndrome or symptoms associated with irritable bowel syndrome.
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公开(公告)号：EP3263100B1
公开(公告)日：2020-04-01
申请号：EP17185173.6
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine Henderson , WATT, Stephen William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46 , C07C57/32
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19.发明公开
公开(公告)号：EP3352748A1
公开(公告)日：2018-08-01
申请号：EP16849626.3
申请日：2016-09-22
发明人： ROSE, Christopher, F. , CLÉMENT, Marc-André , BOSOI, Cristina, R. , OLIVEIRA, Mariana, Macedo , TREMBLAY, Mélanie , BÉMEUR, Chantal
IPC分类号： A61K31/198 , A61K31/192 , A61K31/195 , A61P25/00 , A61P1/16
CPC分类号： A61K31/192 , A61K31/198 , A61K2300/00
摘要： Disclosed herein are methods of treating and preventing neuronal cell loss in a subject using ornithine in combination with phenylacetate or phenylbutyrate. In some embodiments, the subject has received or will receive a surgical procedure (for example, liver transplantation) for treating a liver disease. In some embodiments, the subject suffers from a liver disease and hypotension.
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公开(公告)号：EP2210612B1
公开(公告)日：2016-10-05
申请号：EP10001568.4
申请日：2004-06-18
发明人： Marsault, Eric , Benakli, Kamel , Peterson, Mark , Beaubien, Sylvie , St-Louis, Carl , Ouellet, Luc , Beauchemin, Sophie , Hoveyda, Hamid
IPC分类号： A61K38/22 , C07K5/08 , C07C13/00 , C07C15/00 , C07D213/00
CPC分类号： C07C213/08 , A61K38/12 , A61K38/2214 , C07C41/18 , C07C67/343 , C07D273/00 , C07D413/06 , C07D498/04 , C07K5/0812 , C07K5/0821 , C07K5/0827
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