公开(公告)号：EP1497464A1

公开(公告)日：2005-01-19

申请号：EP03726411.6

申请日：2003-04-23

申请人： U.S. Genomics, Inc.

发明人： GILMANSHIN, Rudolf ,  GONCALVES, Nuno

IPC分类号： C12Q1/68

CPC分类号： C40B40/06 ,  C12Q1/6816 ,  C12Q1/6839 ,  C40B30/04 ,  C12Q2525/197 ,  C12Q2525/107

摘要： The invention provides compositions and methods of use relating to nucleic acid detection probes that comprise a Hoogsteen binding arm and a Watson-Crick binding arm that bind to adjacent but not identical target sites.

公开(公告)号：EP1402245B1

公开(公告)日：2009-07-29

申请号：EP02737289.5

申请日：2002-05-31

申请人： U.S. Genomics, Inc.

发明人： CHAN, Eugene, Y. ,  GLEICH, Lance, C. ,  WELLMAN, Parris, S.

IPC分类号： G01N15/14

CPC分类号： B01L3/502761 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2200/0663 ,  B01L2300/0816 ,  B01L2400/086 ,  C12Q1/6869 ,  G01N1/286 ,  G01N15/1456 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/442 ,  G01N2015/1075 ,  G01N2015/1493 ,  G01N2015/1495 ,  Y10T436/13 ,  Y10T436/143333

摘要： In a method and apparatus for determining the velocity of an elongated polymeric molecule, the molecule (105) is moved relative to one or more detection stations (101,.102, 103). Time correlated detection signals are used to determine velocity, length, and distance between landmarks on the molecule (105).

公开(公告)号：EP1904653A2

公开(公告)日：2008-04-02

申请号：EP06787065.9

申请日：2006-07-13

申请人： U.S. Genomics, Inc.

发明人： YANTZ, Gregory, R. ,  LARSON, Jonathan, W. ,  GILMANSHIN, Rudolf

IPC分类号： C12Q1/68 ,  G01N15/06 ,  G01N35/00 ,  G01N33/00

CPC分类号： B82Y10/00 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0663 ,  B01L2400/0487 ,  B82Y5/00

摘要： Microfludic channels are constructed for use in preparing and/or analyzing samples. In one embodiment, a microfluidic channel receives a carrier fluid having both non-targets and targets. The non-targets are moved from the carrier fluid by diffusion and into sheathing fluids also present in the channel before contents of the carrier fluid are analyzed. In another embodiment, a microchannel delivers multiple fluid samples from an upstream portion to a downstream portion of the channel where each of the fluid samples are separated from one another by a sheathing fluid that also travels toward the downstream portion. In another embodiment, a microchannel is constructed to create multiple elongational flows in series that can align polymers from a coiled state.

公开(公告)号：EP1651778A1

公开(公告)日：2006-05-03

申请号：EP04779075.3

申请日：2004-07-23

申请人： U.S. Genomics, Inc.

发明人： NEELY, Lori ,  HACKETT, Maria

IPC分类号： C12Q1/68

CPC分类号： B82Y5/00 ,  B82Y10/00 ,  C12Q1/68 ,  C12Q1/6816 ,  C12Q1/6869 ,  C12Q2527/137 ,  C12Q2521/313 ,  C12Q2521/125 ,  C12Q2563/137 ,  C12Q2521/301 ,  C12Q2522/101

摘要： The invention relates to methods, products and systems for analyzing nucleic acid molecules using a nucleic acid binding protein such as a sequence-specific endonuclease. The methods can be used to obtain sequence information about the nucleic acid molecules.

公开(公告)号：EP1620203A2

公开(公告)日：2006-02-01

申请号：EP04750184.6

申请日：2004-04-08

申请人： U.S. Genomics, Inc.

发明人： FUCHS, Martin ,  LARSON, Jonathan

IPC分类号： B01L3/00

CPC分类号： G01N35/00069 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0663 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2400/0463 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N15/1475 ,  G01N2015/1006 ,  G01N2015/1413

摘要： A microfluidic device for altering the flow of a carrier fluid containing a polymer, such that, the polymer can be positioned, aligned, or elongated. The device accomplishes these effects by directing the carrier fluid in a laminar flow into obstacles, or other fluids to knowingly alter the path of the carrier fluid streamlines. These streamlines, in turn, apply fluidic drag forces against the polymer to manipulate it into a desired configuration. Other aspects of the device retain a polymer in an aligned or elongated state with crimps which prevent portions of the polymer from coiling. These structures utilize the natural concept of increasing entropy to allow small portions of an aligned or elongated polymer to return to a high entropy, or coiled state, while retaining the majority of the polymer in a low entropy, aligned or elongated state for subsequent analysis or manipulation.

公开(公告)号：EP1540017A2

公开(公告)日：2005-06-15

申请号：EP03811981.4

申请日：2003-05-09

申请人： U.S. Genomics, Inc.

发明人： CHAN, Eugene, Y. ,  NALEFSKI, Eric

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： B82Y5/00 ,  B82Y10/00 ,  C12Q1/6827 ,  C12Q1/6858 ,  C12Q2565/601 ,  C12Q2565/102 ,  C12Q2535/131 ,  C12Q2537/143 ,  C12Q2535/125

摘要： Disclosed herein are methods for analyzing a nucleic acid.

公开(公告)号：EP1402071A2

公开(公告)日：2004-03-31

申请号：EP02747887.4

申请日：2002-06-10

申请人： U.S. Genomics, Inc.

发明人： SHIA, Michael, A. ,  WONG, Gordon, G.

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6827 ,  C12Q2521/125 ,  C12Q2522/101 ,  C12Q2563/131

摘要： The invention relates to methods, products and systems for analyzing nucleic acid molecules based on their in vivo methylation status. The methods can be used to obtain sequence information about the nucleic acid molecules, to analyze differential gene expression associated with disorders, and to assess the efficacy of therapeutic treatments that affect methylation status.