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21 条记录 (耗时 0.017 秒)

    Silicon-containing linkers for nucleic acid mass markers
    12.
    发明公开
    Silicon-containing linkers for nucleic acid mass markers 审中-公开
    Silicium enthaltende LinkerfürNukleinsäure-Massmarker

    公开(公告)号：EP1275655A1

    公开(公告)日：2003-01-15

    申请号：EP02021105.8

    申请日：1999-07-13

    申请人： Xzillion GmbH & CO.KG

    发明人： Thompson, Andrew Hugin ,  Schmidt, Gunter ,  Johnstone, Robert Alexander Walker

    IPC分类号： C07H21/00 ,  C12Q1/68

    CPC分类号： C07H23/00 ,  C07H21/00 ,  C12Q1/6872 ,  C40B40/00

    摘要： Provided is a method for characterising an analyte, which method comprises:

    (a) providing a compound in which the analyte is attached by a cleavable linker to a reporter group relatable to the analyte, the linker having the following formula:
       wherein R 1 and R 2 are substituents as defined in any of claims 1-4 16 and 17;
    (b) cleaving the reporter group from the analyte; and
    (c) identifying the reporter group, thereby characterising the analyte.

    摘要翻译： 提供了一种用于表征分析物的方法，该方法包括：（a）提供其中分析物通过可切割接头连接到与分析物相关的报告基团的化合物，所述接头具有下式：其中R R 1和R 2是如权利要求1-4-16和17中任一项所定义的取代基; （b）从分析物裂解报道基团; 和（c）识别报告基团，从而表征分析物。

    MASS LABELS
    13.
    发明公开
    MASS LABELS 有权
    地面标记

    公开(公告)号：EP1275004A2

    公开(公告)日：2003-01-15

    申请号：EP01911912.2

    申请日：2001-03-14

    申请人： Xzillion GmbH & Co.KG

    发明人： SCHMIDT, Gunter ,  THOMPSON, Andrew Hugin ,  JOHNSTONE, Robert Alexander Walker

    IPC分类号： G01N33/58 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： C07H21/00 ,  C07K1/1077 ,  C12Q1/6872 ,  C40B40/00 ,  G01N33/6803 ,  G01N2458/15 ,  Y10T436/13

    摘要： Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker to a mass normalisation moiety, the mass marker moiety being fragmentation resistant, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectrometry.

    CHIMAERIC OLIGONUCLEOTIDES AND USES THEREOF IN THE IDENTIFICATION OF ANTISENSE BINDING SITES
    16.
    发明授权
    CHIMAERIC OLIGONUCLEOTIDES AND USES THEREOF IN THE IDENTIFICATION OF ANTISENSE BINDING SITES 失效
    嵌合寡核苷酸及其用途在反义结合位点的鉴定

    公开(公告)号：EP0857208B1

    公开(公告)日：2007-07-11

    申请号：EP96930282.7

    申请日：1996-09-13

    申请人： Xzillion GmbH & CO.KG

    发明人： SCHMIDT, Gunter

    IPC分类号： C12N15/11 ,  C07H21/00 ,  A61K31/70

    CPC分类号： C07H21/00

    摘要： A chimaeric oligonucleotide library for use in identifying an antisense binding site in a target mRNA, comprising a plurality of distinct chimaeric oligonucleotides capable of hybridizing to mRNA to form a duplex, the nucleotide sequences of which each have a common length of 7 to 20 bases and are generated randomly or generated from information characterising the sequence of the target mRNA, wherein substantially all the nucleotide sequences of said common length which are present as sub-sequences in the target mRNA are present in the library, and wherein each nucleotide sequence comprises: a) a recognition region comprising a sequence of nucleotides which is recognisable by a duplex-cutting RNAase when hybridized to the mRNA, and b) a flanking region comprising a sequence of chemically-modified nucleotides which binds to the mRNA sufficiently tightly to stabilise the duplex for cutting of the mRNA in the duplex by the duplex-cutting RNAase, wherein the nucleotides constituting the flanking region are different from those constituting the recognition region, and wherein each oligonucleotide is protected against exonuclease attack.

    Mass label linked hybridisation probes
    19.
    发明公开
    Mass label linked hybridisation probes 失效
    Massenmarkierte Hybridisierungssonden

    公开(公告)号：EP1400599A1

    公开(公告)日：2004-03-24

    申请号：EP03076965.7

    申请日：1998-01-15

    申请人： Xzillion GmbH & CO.KG

    发明人： Schmidt, Gunter ,  Thompson, Andrew Hugin ,  Johnstone, Robert Alexander Walker

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6837 ,  C12Q1/6816 ,  C12Q1/6872 ,  C12Q1/6874

    摘要： An array of hybridisation probes, each of which comprises a mass label linked to a known base sequence of predetermined length, wherein each mass label of the array, optionally together with the known base sequence, is relatable to that base sequence by mass spectrometry.

    摘要翻译： 杂交探针的阵列，每个探针包含与已知碱基序列连接的质量标签，其具有预定长度的已知碱基序列，其中阵列的每个质量标签（可选地与已知碱基序列一起）可通过质谱法与该碱基序列相关。