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公开(公告)号：EP1263724A1
公开(公告)日：2002-12-11
申请号：EP01908557.0
申请日：2001-02-23
申请人： AstraZeneca AB
发明人： BODKIN, MichaelLilly Research Centre , ERIKSSON, Tomas , HANSEN, Peter , HEMMERLING, Martin , HENRIKSSON, Krister , KLINGSTEDT, Tomas , PETTERSSON, Lars
IPC分类号： C07D207/04 , C07D211/06 , C07D295/08 , A61K31/40 , A61K31/435 , A61P11/00 , A61P37/00 , A61P19/00 , A61P31/00
CPC分类号： C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/46 , C07D211/58 , C07D295/088 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The invention provides compounds of general formula (I) wherein Q, R, R?2, R4, R5, R6, R7 and R8¿ are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了其中Q，R 1，R 2，R 4，R 5，R 6，R 7和R 8如说明书中所定义的通式（I）的化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途 。
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公开(公告)号：EP4433464A1
公开(公告)日：2024-09-25
申请号：EP22829583.8
申请日：2022-11-17
申请人： Astrazeneca AB
发明人： HEMMERLING, Martin , CZECHTIZKY, Werngard , ULKOSKI, David , POTE, Aditya Ravindra , LINDFORS, Lennart
IPC分类号： C07D305/06 , C07D305/14 , C07D307/06 , C07D309/04 , C12N15/00 , A61K31/337 , A61K31/34
CPC分类号： C07D305/06 , C07D305/14 , C07D307/06 , C07D309/04 , C12N15/88 , A61K48/0041
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公开(公告)号：EP3197878B1
公开(公告)日：2019-07-24
申请号：EP15775130.6
申请日：2015-09-23
申请人： Astrazeneca AB
发明人： RIPA, Lena, Elisabeth , LAWITZ, Karolina , LEPISTÖ, Matti Juhani , HEMMERLING, Martin , EDMAN, Karl , LLINAS, Antonio
IPC分类号： C07D401/04 , A61K31/4439 , A61P19/02
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公开(公告)号：EP2291369B1
公开(公告)日：2015-11-04
申请号：EP09750866.7
申请日：2009-05-20
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
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15.发明公开INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS 有权INDAZOLYLAMIDDERIVATE用于治疗由糖皮质激素介导的疾病
公开(公告)号：EP2102169A1
公开(公告)日：2009-09-23
申请号：EP07852132.5
申请日：2007-12-20
发明人： BERGER, Markus , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HANSSON, Thomas , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , McKERRECHER, Darren , MUNCK AF ROSENSCHÖLD, Magnus , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla , EDMAN, Karl
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4709 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
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16.发明公开NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开新三环SPIROPIPERIDINVERBINDUNGEN，它们的合成及它们作为趋化因子受体调节剂
公开(公告)号：EP2069355A1
公开(公告)日：2009-06-17
申请号：EP07748335.2
申请日：2007-07-17
申请人： AstraZeneca AB
发明人： ERIKSSON, Tomas , HEMMERLING, Martin , JOSEFSSON, Bo-Göran , IVANOVA, Svetlana , MENSONIDES-HARSEMA, Marguérite , MO, John , PAVEY, John , PIMM, Austen , REUBERSON, James , SCHULZ, Håkan , STRANDBERG, Per
IPC分类号： C07D491/107 , A61K31/438 , A61P11/00 , C07C235/60 , C07D211/48 , C07D303/23
CPC分类号： C07C233/25 , C07C69/92 , C07C235/60 , C07D211/48 , C07D303/23 , C07D491/107
摘要： Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.
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公开(公告)号：EP1625126B1
公开(公告)日：2008-01-16
申请号：EP04731525.4
申请日：2004-05-06
申请人： AstraZeneca AB
IPC分类号： C07D471/04 , C07D513/04 , C07D498/04 , A61K31/437 , A61P11/06 , A61P37/00 , A61P19/02
CPC分类号： C07D513/04 , C07D471/04
摘要： The present invention relates to novel imidazo and thiazolopyridine compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them. Formula (I)
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