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公开(公告)号：EP1286673B1
公开(公告)日：2005-05-25
申请号：EP01945258.0
申请日：2001-06-06
发明人： GENESTE, Hervé , KLING, Andreas , LANGE, Udo , SEITZ, Werner , GRAEF, Claudia, Isabella , SUBKOWSKI, Thomas , HORNBERGER, Wilfried , LAUTERBACH, Arnulf
IPC分类号： A61K31/55 , A61K31/5513 , C07K5/023 , C07D277/08 , C07D417/12 , C07D333/38 , C07D263/48 , C07D409/12 , C07D413/12 , C07D307/68 , A61P9/00 , A61P31/00 , A61P35/00 , A61P19/00 , A61P29/00 , A61P17/00
CPC分类号： A61K45/06
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12.发明授权DIPEPTIDISCHE P-AMIDINOBENZYLAMIDE MIT N-TERMINALEN SULFONYL- BZW. AMINOSULFONYLRESTEN 失效DIPEPTIDISCHE对氨基苯甲酰胺MIT N-TERMINALEN SULFONYL-BZW. AMINOSULFONYLRESTEN
公开(公告)号：EP0796271B1
公开(公告)日：2000-02-02
申请号：EP95941015.0
申请日：1995-11-25
发明人： BÖHM, Hans Joachim , KOSER, Stefan , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , HÖFFKEN, Hans Wolfgang , HORNBERGER, Wilfried , ZIERKE, Thomas
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06026 , C07K5/06043 , C07K5/06078 , C07K5/06113
摘要： The invention pertains to compounds of formula (I), wherein R1, A and B are as indicated in the description, and to their preparation. The new compounds can be used for combatting diseases.
摘要翻译： 本发明涉及式（I）的化合物及其制备方法，其中R1，A和B如说明书中所示。 新化合物可用于对抗疾病。
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公开(公告)号：EP0956294A1
公开(公告)日：1999-11-17
申请号：EP97936672.0
申请日：1997-07-29
发明人： BAUCKE, Dorit , LANGE, Udo , MACK, Helmut , SEITZ, Werner , ZIERKE, Thomas , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried
CPC分类号： C07K5/06078 , A61K38/00
摘要： Compounds having formula (I) wherein A, B, E and D have the m eanings indicated in the description, are described, in addition to the production thereof. The substances can be used to combat illnesses.
摘要翻译： 描述了式（I）的化合物，其中A，B，E和D具有在说明书中指出的含义。 这些物质可以用来对抗疾病。
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14.发明公开NEUE DIPEPTIDISCHE P-AMIDINOBENZYLAMIDE MIT N-TERMINALEN SULFONYL- BZW. AMINOSULFONYLRESTEN 失效NEUE DIPEPTIDISCHE P-AMIDINOBENZYLAMIDE MIT N-TERMINALEN SULFONYL-BZW. AMINOSULFONYLRESTEN
公开(公告)号：EP0796271A1
公开(公告)日：1997-09-24
申请号：EP95941015.0
申请日：1995-11-25
发明人： BÖHM, Hans Joachim , KOSER, Stefan , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , HÖFFKEN, Hans Wolfgang , HORNBERGER, Wilfried , ZIERKE, Thomas
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06026 , C07K5/06043 , C07K5/06078 , C07K5/06113
摘要： The invention pertains to compounds of formula (I), wherein R1, A and B are as indicated in the description, and to their preparation. The new compounds can be used for combatting diseases.
摘要翻译： 本发明涉及式（I）的化合物及其制备方法，其中R1，A和B如说明书中所示。 新化合物可用于对抗疾病。
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15.发明公开
公开(公告)号：EP1307443A2
公开(公告)日：2003-05-07
申请号：EP01971899.8
申请日：2001-08-09
发明人： GENESTE, Herve , KLING, Andreas , LAUTERBACH, Arnulf , GRAEF, Claudia, Isabella , SUBKOWSKI, Thomas , HORNBERGER, Wilfried
IPC分类号： C07D401/12 , C07D403/12 , A61K31/55 , A61P7/02
CPC分类号： A61K45/06
摘要： The invention relates to novel compounds which bind to integrin receptors, in particular as ligands for the αVβ3 integrin receptor, the use thereof and pharmaceutical preparations containing said compounds.
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公开(公告)号：EP1289962A1
公开(公告)日：2003-03-12
申请号：EP01964986.2
申请日：2001-06-15
发明人： GENESTE, Hervé , KLING, Andreas , LANGE, Udo , LAUTERBACH, Arnulf , SEITZ, Werner , GRAEF, Claudia, Isabella , SUBKOWSKI, Thomas , HORNBERGER, Wilfried
IPC分类号： C07D223/16 , C07D403/12 , A61K31/55 , A61P9/00
CPC分类号： A61K45/06
摘要： The invention relates to compounds of formula B-G-U-T, where T = amongst others, a COOH group, U = a linker group, G = an optionally condensed azepine or diazepine group and B = a structural element, containing at least one atom which can function as an H-acceptor under physiological conditions to form hydrogen bonds. Said compounds bind to integrin receptors, in particular to αVβ3 integrin receptors.
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17.发明公开INHIBITORS OF THE ENDOTHELIN SIGNALLING PATHWAY AND ALPHAVBETA3 INTEGRIN RECEPTOR ANTAGONISTS FOR COMBINATION THERAPY 审中-公开抑制剂内皮素介导的信号转导通路及整合素αVβ3受体拮抗剂联合治疗
公开(公告)号：EP1227847A2
公开(公告)日：2002-08-07
申请号：EP00969395.3
申请日：2000-10-02
IPC分类号： A61K45/06
CPC分类号： C07D263/34 , A61K38/00 , A61K45/06 , C07D239/34 , C07D277/48 , C07D307/68 , C07D333/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07K5/0202
摘要： The invention relates to the use of an endothelin blocker in combination with an αvβ3 integrin receptor antagonist for the treatment or prevention of diseases, particularly to the use of a pharmaceutical composition, comprising an endothelin blocker and an αvβ3 integrin receptor antagonist, for the treatment or prevention of cardiovascular disorders, particularly for the treatment or prevention of restenosis after vessel injury or revascularisation treatment and to the pharmaceutical composition itself.
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公开(公告)号：EP1202988A2
公开(公告)日：2002-05-08
申请号：EP00958347.7
申请日：2000-08-01
发明人： KLING, Andreas , GENESTE, Hervé , LANGE, Udo , LAUTERBACH, Arnulf , GRAEF, Claudia, Isabella , SUBKOWSKI, Thomas , HOLZENKAMP, Uta , MACK, Helmut , SADOWSKI, Jens , HORNBERGER, Wilfried , LAUX, Volker
IPC分类号： C07D401/12 , A61K31/55 , A61P43/00 , C07D401/14 , C07D213/73 , C07D403/12 , C07D491/04 , C07D409/14
CPC分类号： C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
摘要： The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL1RL2)b-, -CR¿L?1=CRL2-, ethylene or =CR¿L?1-, wherein a is 0 or 1; b is 0, 1 or 2; X¿L? represents CRL?3R¿L4, NRL5, oxygen or sulfur and G is a structural element of formula I¿G?, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG?1¿. The invention also relates to the production of said compounds and to their use as medicaments.
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公开(公告)号：EP1171435A2
公开(公告)日：2002-01-16
申请号：EP00920612.9
申请日：2000-03-29
发明人： ZECHEL, Johann-Christian , KLING, Andreas , GENESTE, Hervé , LANGE, Udo , LAUTERBACH, Arnulf , GRAEF, Claudia, Isabella , SUBKOWSKI, Thomas , SADOWSKI, Jens , HORNBERGER, Wilfried
IPC分类号： C07D401/14 , A61K31/505 , A61P9/10 , C07D401/12 , C07D239/46 , C07D403/12 , C07D403/14 , C07D403/04 , C07D405/14 , C07D417/14 , C07D409/14 , C07D417/12
CPC分类号： C07D405/14 , A61K45/06 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The invention relates to novel compounds that bind to integrin receptor ligands. The invention also relates to the production thereof, to their use as integrin receptor ligands and to their use for treating diseases, to pharmaceutical preparations that contain said compounds and to pharmaceutical preparations that contain at least one additional active compound.
摘要翻译： 本发明涉及结合整联蛋白受体，其制备，作为整联蛋白受体配体和用于治疗疾病的药物，包含这些化合物的药物制剂以及包含至少一种其它活性化合物的药物制剂的新型化合物。
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公开(公告)号：EP1051431A1
公开(公告)日：2000-11-15
申请号：EP99908818.0
申请日：1999-01-23
发明人： BAUCKE, Dorit , LANGE, Udo , MACK, Helmut , SEITZ, Werner , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried
CPC分类号： C07K5/06191 , A61K38/00 , C07K5/06078
摘要： The invention relates to compounds of the formula A-B-D-E-F, in which A, B, D, E and F have the meanings given in the description, and to their production. These new compounds are suitable for producing medicines.
摘要翻译： 本发明涉及式A-B-D-E-F的化合物，其中A，B，D，E和F具有在说明书中给出的含义及其制备。 这些新化合物适用于生产药物。
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