-
公开(公告)号：EP2928884B1
公开(公告)日：2017-05-24
申请号：EP13798684.0
申请日：2013-12-03
发明人： PETERS, Olaf , BRÄUER, Nico , BLUME, Thorsten , TER LAAK, Antonius , ZORN, Ludwig , NAGEL, Jens , KAULFUSS, Stefan , LANGER, Gernot , KUHNKE, Joachim
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
-
公开(公告)号：EP2920176A1
公开(公告)日：2015-09-23
申请号：EP13795702.3
申请日：2013-11-14
发明人： ZORN, Ludwig , EIS, Knut , SCHULZE, Volker , SÜLZLE, Detlev , PÜHLER, Florian , LIENAU, Philip , BÖMER, Ulf , PETERSEN, Kirstin , HÄGEBARTH, Andrea
IPC分类号： C07D487/04 , A61K31/4355 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , C07D519/00
摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并哒嗪化合物，其中A，R 1，R 2，R 3，R 4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂的用途或 与其他活性成分组合。
-
13.发明公开N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权N-（吡啶-2-基）吡啶并[4-AMIN-DERIVATE MIT EINER SULFOXIMINGRUPPE]
公开(公告)号：EP2920164A1
公开(公告)日：2015-09-23
申请号：EP13794844.4
申请日：2013-11-13
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D401/12 , A61K31/506 , A61P9/00 , A61P35/00
CPC分类号： C07D401/12 , A61K31/506
摘要： The present invention relates to disubstituted N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/ or prophylaxis of disorders, in particular of hyper- proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的磺酰亚胺基的二取代的N-（吡啶-2-基）嘧啶-4-胺衍生物及其制备方法及其用于治疗和/ 或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
-
14.发明公开N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权甲砜基团含有N-（吡啶-2-基）嘧啶-4-胺衍生物
公开(公告)号：EP2909200A2
公开(公告)日：2015-08-26
申请号：EP13777070.7
申请日：2013-10-16
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D405/14 , C07D401/12 , A61K31/506 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D401/12 , A61K31/506 , A61K45/06 , C07D207/44 , C07D233/88 , C07D405/14 , A61K2300/00
摘要： The present invention relates to N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
-
15.发明授权C-RING-SUBSTITUIERTE PREGN-4-EN-21,17-CARBOLACTONE, SOWIE DIESE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE 有权C-环取代的孕-4- EN-21,17-carbolactones和药物制剂含有它们
公开(公告)号：EP2297177B1
公开(公告)日：2012-06-20
申请号：EP09757194.7
申请日：2009-05-26
发明人： RING, Sven , BOHLMANN, Rolf , KUHNKE, Joachim , ZORN, Ludwig , BORDEN, Steffen , PRELLE, Katja
CPC分类号： C07J53/008
摘要： The present invention relates to C-ring-substituted pregn-4-ene-21,17-carbolactones of the general formula I in which R
6,7 is an α- or β-methylene and R
9 is a hydrogen atom and R
11 is a bromine, chlorine or fluorine atom or R
9 and R
11 together are a bond. The novel compounds are gestagenic antimineralocorticoids.-
公开(公告)号：EP3325451A1
公开(公告)日：2018-05-30
申请号：EP16757565.3
申请日：2016-07-14
发明人： PANKNIN, Olaf , HARTUNG, Ingo , REHWINKEL, Hartmut , NGUYEN, Duy , ZORN, Ludwig , HELFRICH, Petra , ZIMMERMANN, Katja , NEUHAUS, Roland
IPC分类号： C07D235/30 , C07D471/04 , A61P35/00 , A61K31/437 , A61K31/4184
CPC分类号： C07D235/30 , A61K31/4184 , A61K31/437 , A61K45/06 , A61P35/00 , C07D471/04 , C12P17/10
摘要： The present invention relates to compounds of general formula (I) : in which R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
-
17.发明公开N-PHENYL-(MORPHOLIN-4-YL OR PIPERAZINYL)ACETAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAYS 审中-公开N-苯基 - （吗啉-4-基或哌嗪基）乙酰胺衍生物及其作为Wnt信号通路抑制剂的用途
公开(公告)号：EP3259251A1
公开(公告)日：2017-12-27
申请号：EP16704645.7
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William, J. , GIESE, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D213/73 , C07D231/12 , C07D403/04 , C07D239/26 , C07D239/34 , C07D239/42 , C07D213/40 , C07D213/61 , C07D213/64 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/5377 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/73 , C07D231/12 , C07D239/26 , C07D239/34 , C07D239/42 , C07D403/04
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) wherein LA represents *CH2** or *Δ**; wherein indicates the point of attachment to the carbonyl group, and ** indicates the point of attachment to R1; LB represents *N(H)-C(=O)** or *C(=O)-N(H)**; wherein * indicates the point of attachment to R2, and ** indicates the point of attachment to the phenyl group; R1 represents a group selected from: (AA); wherein * indicates the point of attachment to LA, R2 represents: (BB) wherein * indicates the point of attachment to R3, and ** indicates the point of attachment to LB R3 represents a group selected from: (CC); wherein * indicates the point of attachment to R2; R4 and R5 represent a hydrogen atom; and R6 represents a halogen atom or group selected from: -CH3, -O-CH3, -O-CHF2, -O-CF3, and -O-cyclopropyl; to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular, of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
-
18.发明授权N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权甲砜基团含有N-（吡啶-2-基）嘧啶-4-胺衍生物
公开(公告)号：EP2909200B1
公开(公告)日：2016-11-23
申请号：EP13777070.7
申请日：2013-10-16
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D207/44 , C07D233/88 , C07D401/12 , C07D405/14 , A61K45/06 , A61K31/506
CPC分类号： C07D401/12 , A61K31/506 , A61K45/06 , C07D207/44 , C07D233/88 , C07D405/14 , A61K2300/00
-
19.发明授权5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权砜基包含5-氟-N-（吡啶-2-基）吡啶-2-胺衍生物
公开(公告)号：EP2909176B1
公开(公告)日：2016-07-20
申请号：EP13782670.7
申请日：2013-10-15
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D213/74 , C07D405/14 , A61K31/506 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D213/74 , A61K31/444 , C07D405/14
-
公开(公告)号：EP2834245A1
公开(公告)日：2015-02-11
申请号：EP13712784.1
申请日：2013-03-27
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHULZE, Volker , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , PETERSEN, Kirstin , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D405/04 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D487/04
摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I); in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并哒嗪化合物。 其中A，R 1，R 2，R 3，R 4，R 5和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合， 的所述化合物用于制造用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合。
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.032 秒)
