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11.发明公开
公开(公告)号：EP1656138A2
公开(公告)日：2006-05-17
申请号：EP04781805.9
申请日：2004-08-20
发明人： CARTER, Percy, H. , CHERNEY, Robert, J. , BATT, Douglas, G. , BROWN, Gregory, D. , DUNCIA, John, V. , GARDNER, Daniel, S. , YANG, Michael, G.
IPC分类号： A61K31/421 , A61K31/422 , C07D413/12
CPC分类号： C07C237/22 , C07B2200/07 , C07C275/42 , C07C2601/14 , C07D205/04 , C07D207/34 , C07D213/38 , C07D213/64 , C07D213/65 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/40 , C07D231/56 , C07D233/56 , C07D235/30 , C07D239/28 , C07D239/42 , C07D239/94 , C07D257/04 , C07D261/20 , C07D271/06 , C07D277/28 , C07D295/205 , C07D295/215 , C07D307/66 , C07D307/68 , C07D401/04 , C07D413/12 , C07D487/04
摘要： The present application describes modulators of MCP-1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
摘要翻译： 本申请描述了可用于预防哮喘，多发性硬化，动脉粥样硬化和类风湿性关节炎的式（I）的MCP-1或其药学上可接受的盐形式的调节剂。
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公开(公告)号：EP2776409B1
公开(公告)日：2016-02-03
申请号：EP12787341.2
申请日：2012-11-09
发明人： SEIGAL, Benjamin, Adam , TERRETT, Nicholas , CARTER, Percy, H. , BORZILLERI, Robert, M. , ZHANG, Yong , MILLER, Michael, M.
IPC分类号： C07D249/04 , A61P35/00
CPC分类号： C07D498/22 , A61K38/00 , C07D249/04 , C07D498/16 , C07K5/1008 , C07K7/56 , Y02A50/411 , Y02A50/414
摘要： The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
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13.发明授权BENZYLPYRROLIDINONE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权趋化因子受体活性的BENZYLPYRROLIDINONDERIVATE AS调节剂
公开(公告)号：EP2534158B1
公开(公告)日：2014-01-08
申请号：EP11704004.8
申请日：2011-02-08
IPC分类号： C07D498/04 , C07D207/27 , A61K31/4025 , A61K31/538 , A61P19/00 , A61P29/00
CPC分类号： C07D498/04 , C07D207/27
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公开(公告)号：EP1656345B1
公开(公告)日：2013-10-16
申请号：EP04781806.7
申请日：2004-08-20
发明人： CARTER, Percy, H. , CHERNEY, Robert, J. , BATT, Douglas, G. , DUNCIA, John, V. , GARDNER, Daniel, S. , KO, Soo, S. , SRIVASTAVA, Anurag, S. , YANG, Michael, G.
IPC分类号： C07D207/26 , A61K31/4015
CPC分类号： C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
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15.发明公开BENZYLPYRROLIDINONE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权趋化因子受体活性的BENZYLPYRROLIDINONDERIVATE AS调节剂
公开(公告)号：EP2534158A1
公开(公告)日：2012-12-19
申请号：EP11704004.8
申请日：2011-02-08
IPC分类号： C07D498/04 , C07D207/27 , A61K31/4025 , A61K31/538 , A61P19/00 , A61P29/00
CPC分类号： C07D498/04 , C07D207/27
摘要： The present application describes modulators of MCP-1 or CCR-2 of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R
1 and R
6 , are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.-
公开(公告)号：EP1692161B1
公开(公告)日：2011-12-21
申请号：EP04819114.2
申请日：2004-11-12
发明人： DINCHUK, Joseph E. , DAVIES, Paul , ZHAO, Qihong , CARTER, Percy, H. , SOLOMON, Kimberly, A. , SCHERLE, Peggy Ann
CPC分类号： C07K14/7158 , C12N15/62
摘要： The present invention relates to a chimeric chemokine receptor comprising two components: a first sequence comprising the N terminus through the last residue of the seven helix TM region of a first chemokine receptor joined with a second sequence comprising the C terminus of a second chemokine receptor extending from the first intracellular residue of the chemokine receptor to the last residue of the chemokine receptor. The chimeric chemokine receptor can be employed in various applications, such as ligand binding and screening assays and signalling assays. The chimeric chemokine receptor can also form a component of a chemokine receptor modulator design program.
摘要翻译： 本发明涉及包含两种组分的嵌合趋化因子受体：第一序列，其包含通过第一趋化因子受体的七螺旋TM区的最后一个残基的N末端与包含第二趋化因子受体的C末端的第二序列 从趋化因子受体的第一个细胞内残基到趋化因子受体的最后一个残基。 嵌合趋化因子受体可以用于各种应用，例如配体结合和筛选测定以及信号传导测定。 嵌合趋化因子受体还可以形成趋化因子受体调节剂设计程序的组分。
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公开(公告)号：EP2318352A2
公开(公告)日：2011-05-11
申请号：EP09790359.5
申请日：2009-07-14
发明人： CARTER, Percy, H. , BROWN, Gregory, D. , DE LUCCA, George, V. , BATT, Douglas, G. , LIU, Rui-Qin , QIU, Feng
IPC分类号： C07C61/15 , C07C61/28 , C07C61/39 , C07C61/40 , C07C62/32 , C07C62/34 , C07C233/47 , C07C311/51 , A61K31/18 , A61K31/192 , A61P19/02 , A61P9/12 , A61P11/06 , A61P31/18
CPC分类号： C07C311/51 , C07C61/40 , C07C62/34 , C07C233/47 , C07C2601/16
摘要： The present application describes modulators of MCP-1 or CCR-2 of formula,(I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R
1 , R
2 , R
4 and R
6 , are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula, (I) are disclosed.摘要翻译： 本申请描述了式（I）的MCP-1或CCR-2或其立体异构体或前药或其药学上可接受的盐的调节剂，其中定义T，W，X，Y，Z，R 1，R 2，R 4和R 6 于此。 此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和移植排斥的自身免疫病态的方法。
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公开(公告)号：EP1973880A1
公开(公告)日：2008-10-01
申请号：EP07710312.5
申请日：2007-01-25
IPC分类号： C07D213/56 , C07D295/18 , A61K31/4965 , A61P19/00
CPC分类号： C07D295/185 , C07D213/56
摘要： The present application describes modulators of MIP-1α of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein m, T, W, R1, R4, R5, R5a and R5b are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.
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