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11.发明公开CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES AND THEIR USE AS HISTAMINE H3 RECEPTOR MODULATORS 审中-公开环己基哌嗪基甲酮衍生物及其作为组胺H3受体调节剂
公开(公告)号：EP1976840A1
公开(公告)日：2008-10-08
申请号：EP07703607.7
申请日：2007-01-03
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , ROCHE, Olivier , TAKAHASHI, Tadakatsu , TAYLOR, Sven
IPC分类号： C07D295/182 , A61K31/495 , A61K31/496 , C07D209/08 , C07D209/44 , C07D211/38 , C07D211/46 , C07D213/74 , C07D213/84 , C07D215/08 , C07D217/04 , C07D241/04 , C07D241/20 , C07D243/08 , C07D261/14
CPC分类号： C07D295/185 , C07D209/08 , C07D209/44 , C07D211/38 , C07D211/46 , C07D213/74 , C07D213/84 , C07D215/08 , C07D217/04 , C07D241/04 , C07D241/20 , C07D243/08 , C07D261/14 , C07D295/215 , C07D309/14
摘要： The present invention relates to compounds of formula (I), wherein s, R1a and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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12.发明授权1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS 有权1,1-二氧代硫代吗吲哚基甲酮衍生物FOR USE AS H3调节剂
公开(公告)号：EP1968967B1
公开(公告)日：2011-04-27
申请号：EP06830045.8
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RODRIGUEZ SARMIENTO, Rosa Maria , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , A61K31/445 , A61K31/404 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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13.发明公开1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS 有权1,1-二氧代硫代吗吲哚基甲酮衍生物FOR USE AS H3调节剂
公开(公告)号：EP1968967A1
公开(公告)日：2008-09-17
申请号：EP06830045.8
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RODRIGUEZ SARMIENTO, Rosa Maria , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , A61K31/445 , A61K31/404 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1966199A1
公开(公告)日：2008-09-10
申请号：EP06829951.0
申请日：2006-11-08
IPC分类号： C07D471/04 , A61K31/4453 , A61K31/4462 , A61K31/4465 , A61P3/04 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1957479A2
公开(公告)日：2008-08-20
申请号：EP06830046.6
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RUNTZ-SCHMITT, Valerie , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/4439 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula (I) wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1480976B1
公开(公告)日：2007-09-19
申请号：EP03742945.3
申请日：2003-02-19
发明人： MATTEI, Patrizio , NEIDHART, Werner , NETTEKOVEN, Matthias, Heinrich , PFLIEGER, Philippe , TAYLOR, Sven
IPC分类号： C07D417/06 , C07D277/42 , C07D417/12 , C07D417/14 , A61K31/425
CPC分类号： C07D417/06 , C07D277/42
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
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公开(公告)号：EP1716132A2
公开(公告)日：2006-11-02
申请号：EP05706909.8
申请日：2005-01-18
发明人： PLANCHER, Jean-Marc , TAYLOR, Sven
IPC分类号： C07D317/72 , A61K31/496 , A61K31/5377 , A61P3/04
CPC分类号： C07D317/72
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB 1 receptors.
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