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11.发明授权Herboxidiene derivatives and their preparation from streptomyces GEX1 culture 失效Herboxidiene衍生物和从培养链霉菌GEX1它们的制备
公开(公告)号：EP0781772B1
公开(公告)日：2002-03-27
申请号：EP96120927.7
申请日：1996-12-27
发明人： Mizukami, Tamio , Sakai, Yasushi , Yoshida, Tetsuo, , Uosaki, Youichi, , Ochiai, Keiko, , Akinaga, Shiro,
IPC分类号： C07D407/04 , C07D407/14 , C12P17/06 , A61K31/35
CPC分类号： C07D407/06 , C07D407/14 , C12P17/06
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公开(公告)号：EP0924212A1
公开(公告)日：1999-06-23
申请号：EP98124083.1
申请日：1998-12-18
发明人： Yamashita, Yoshinori , Nakai, Ryuichiro , Mizukami, Tamio , Kakita, Shingo , Chiba, Shigeru , Akinaga, Shiro
IPC分类号： C07D493/20 , C12P17/18 , C12R1/465 , A61K31/365
CPC分类号： C07D493/20 , C12P17/181 , C12R1/465 , Y10S435/886
摘要： The present invention relates to chrolactomycin compound represented by the following formula (I):
or pharmaceutically acceptable salts thereof having antibacterial and antitumor activities.摘要翻译： 本发明涉及由下式（I）表示的己内酰霉素化合物：其具有抗细菌和抗肿瘤活性的
或其药学上可接受的盐。 -
公开(公告)号：EP0849267A1
公开(公告)日：1998-06-24
申请号：EP97122290.6
申请日：1997-12-17
发明人： Mizukami, Tamio , Ogawa, Harumi , Nakai, Ryuichiro , Asai, Akira , Yamashita, Yoshinori , Ando, Katsuhiko , Agatsuma, Tsutomu , Akinaga, Shiro , Ouchi, Kozo , Kawasaki, Hideki
IPC分类号： C07D491/16 , A61K31/40 , C07D487/04 , C12P17/14 , C12N1/14
CPC分类号： C07D487/04 , C12P17/14
摘要： UCS1025 compounds represented by the following formula (I):
wherein R represents hydrogen or hydroxyl group, or tautomers or pharmacologically acceptable salts thereof.摘要翻译： 由下式（I）表示的UCS1025化合物或其互变异构体或其药理学上可接受的盐：其中R表示氢或羟基。
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公开(公告)号：EP0088166B2
公开(公告)日：1997-06-25
申请号：EP82112072.2
申请日：1982-12-28
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公开(公告)号：EP0768317A1
公开(公告)日：1997-04-16
申请号：EP96116414.2
申请日：1996-10-14
发明人： Mizukami, Tamio , Asai, Akira , Yamashita, Yoshinori , Katahira, Ritsuko , Hasegawa, Atsuhiro , Ochiai, Keiko , Akinaga, Shiro
CPC分类号： C07K5/06026 , A61K38/00
摘要： The present invention relates to UCK14 compounds having antitumor activity which are represented by the formula:
wherein R 1 is hydrogen or -COOC(CH 3 ) 3 ; and R 2 and R 3 are taken together to form -CH 2 -, or each R 2 and R 3 independently are hydrogen,
and pharmaceutically acceptable salts thereof.摘要翻译： 本发明涉及具有抗肿瘤活性的UCK14化合物，其由下式表示：其中R 1为氢或-COOC（CH 3）3; 并且R 2和R 3一起形成-CH 2 - ，或每个R 2和R 3独立地是氢，及其药学上可接受的盐。
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公开(公告)号：EP0088166B1
公开(公告)日：1989-03-22
申请号：EP82112072.2
申请日：1982-12-28
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公开(公告)号：EP0249854A3
公开(公告)日：1988-12-21
申请号：EP87108303
申请日：1987-06-09
IPC分类号： C07K13/00 , C12N15/00 , C07H21/04 , C12N01/20 , C12N05/00 , C12P21/00 , A61K37/02 , C12R01/19
CPC分类号： C07K14/4705 , A61K38/00
摘要： According to the present invention, a recombinant DNA wherein a DNA coding for a novel physiologically active polypeptide produced by human erythroleukemia cell strain K562-T1 is incorporated and a microorganism or an animal cell carrying the recombinant DNA can be obtained, and they can be utilized for producing a large amount of the physiologically active polypeptide.
摘要翻译： 根据本发明，可以获得编码由人红白血病细胞株K562-T1产生的新型生理活性多肽的DNA的重组DNA，并且可以获得携带重组DNA的微生物或动物细胞，并且可以利用它们 用于生产大量的生理活性多肽。
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公开(公告)号：EP0166444A3
公开(公告)日：1987-08-19
申请号：EP85107987
申请日：1985-06-27
发明人： Sekine, Susumu , Mizukami, Tamio , Sato, Moriyuki , Itoh, Seiga , Saito, Akiko
CPC分类号： C07K14/61 , Y10S930/12 , Y10S930/31
摘要： According to the present invention, a recombinant DNA incorporated with a DNA coding for a fish growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained and they can be used for mass production of the fish growth hormone polypeptide.
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公开(公告)号：EP0088166A3
公开(公告)日：1984-04-25
申请号：EP82112072
申请日：1982-12-28
发明人： Katsumata, Ryoichi , Ozaki, Akio , Mizukami, Toru , Kageyama, Motoko , Yagisawa, Morimasa , Mizukami, Tamio , Itoh, Seiga , Oka, Tetsuo , Furuya, Akira
摘要： Disclosed is a process for expressing a gene and producing a metabolic product formed by the gene by culturing a transformant microorganism carrying a recombinant DNA constructed of a DNA fragment having at least one gene to be expressed and a vector DNA, at least one of which is foreign to the host microorganism.
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