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公开(公告)号：EP0380373B1
公开(公告)日：1993-05-12
申请号：EP90300868.8
申请日：1990-01-26
发明人： Nakano, Hirofumi , Yamashita, Yoshinori , Ando, Katsuhiko , Saito, Yutaka , Takahashi, Keiichi , Ohno, Hiroe c/o Patent Department
CPC分类号： C12R1/645 , C07C50/36 , C07C2603/44 , C12P29/00
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2.发明公开
公开(公告)号：EP0380373A1
公开(公告)日：1990-08-01
申请号：EP90300868.8
申请日：1990-01-26
发明人： Nakano, Hirofumi , Yamashita, Yoshinori , Ando, Katsuhiko , Saito, Yutaka , Takahashi, Keiichi , Ohno, Hiroe c/o Patent Department
CPC分类号： C12R1/645 , C07C50/36 , C07C2603/44 , C12P29/00
摘要： Compound UCT-1003, which is represented by the following formula:
is novel and has anti-tumor activity. UCT-1003 is produced by culturing a microorganism belonging to the genus Paecilomyces , e.g. Paecilomyces sp. SPC-13780 (FERM BP-2256).摘要翻译： 化合物UCT-1003，由下式表示：
是新型的，具有抗肿瘤活性。 UCT-1003是通过培养属于拟青霉属的微生物，例如， 拟青霉菌 SPC-13780（FERM BP-2256）。 -
公开(公告)号：EP0768317B1
公开(公告)日：1999-01-27
申请号：EP96116414.2
申请日：1996-10-14
发明人： Mizukami, Tamio , Asai, Akira , Yamashita, Yoshinori , Katahira, Ritsuko , Hasegawa, Atsuhiro , Ochiai, Keiko , Akinaga, Shiro
CPC分类号： C07K5/06026 , A61K38/00
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公开(公告)号：EP0573976B1
公开(公告)日：1995-10-18
申请号：EP93109273.8
申请日：1993-06-09
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公开(公告)号：EP1847534A2
公开(公告)日：2007-10-24
申请号：EP07015426.5
申请日：2002-12-11
发明人： Murakata, Chikara , Kato, Kazuhiko , Ohta, Yoshihisa , Nakai, Ryuichiro , Yamashita, Yoshinori , Takahashi, Takeshi , Nakano, Tomohisa , Ino, Yoji
IPC分类号： C07D285/135 , C07D417/04 , C07D285/14 , A61K31/433 , A61K31/5377 , A61P35/00
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/5377
摘要： (wherein R 1 and R 4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R 5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R 2 represents -C(=W)R 6 or the like; R 3 represents a hydrogen atom, -C(=W A )R 6A , or the like)
Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.摘要翻译： （其中R 1和R 4相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的低级炔基，取代或未取代的低级链烯基等; R 5表示取代或未取代的杂环基 取代或未取代的芳基等; R 2表示-C（= W）R 6等; R 3表示氢原子，-C（= WA）R 6A等）抗肿瘤剂，其包含 提供由上述通式（I）表示的噻二唑啉衍生物或其药理学上可接受的盐作为有效成分。
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公开(公告)号：EP0228700B1
公开(公告)日：1989-07-19
申请号：EP86117994.3
申请日：1986-12-23
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Yamashita, Yoshinori , Kawamoto, Isao , Ando, Katsuhiko , Sano, Hiroshi , Yasuzawa, Toru , Shuto, Katsuichi
CPC分类号： C12P33/00 , C07J71/001
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公开(公告)号：EP0228700A1
公开(公告)日：1987-07-15
申请号：EP86117994.3
申请日：1986-12-23
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Yamashita, Yoshinori , Kawamoto, Isao , Ando, Katsuhiko , Sano, Hiroshi , Yasuzawa, Toru , Shuto, Katsuichi
CPC分类号： C12P33/00 , C07J71/001
摘要： Novel substance UCYl003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities:
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公开(公告)号：EP1847534A3
公开(公告)日：2008-09-24
申请号：EP07015426.5
申请日：2002-12-11
发明人： Murakata, Chikara , Kato, Kazuhiko , Ohta, Yoshihisa , Nakai, Ryuichiro , Yamashita, Yoshinori , Takahashi, Takeshi , Nakano, Tomohisa , Ino, Yoji
IPC分类号： C07D285/135 , C07D417/04 , C07D285/14 , A61K31/433 , A61P35/00
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/5377
摘要： (wherein R 1 and R 4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R 5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R 2 represents -C(=W)R 6 or the like; R 3 represents a hydrogen atom, -C(=W A )R 6A , or the like)
Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.-
公开(公告)号：EP0849267B1
公开(公告)日：2001-09-26
申请号：EP97122290.6
申请日：1997-12-17
发明人： Mizukami, Tamio , Ogawa, Harumi , Nakai, Ryuichiro , Asai, Akira , Yamashita, Yoshinori , Ando, Katsuhiko , Agatsuma, Tsutomu , Akinaga, Shiro , Ouchi, Kozo , Kawasaki, Hideki
IPC分类号： C07D491/16 , A61K31/40 , C07D487/04 , C12P17/14 , C12N1/14
CPC分类号： C07D487/04 , C12P17/14
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公开(公告)号：EP0924212A1
公开(公告)日：1999-06-23
申请号：EP98124083.1
申请日：1998-12-18
发明人： Yamashita, Yoshinori , Nakai, Ryuichiro , Mizukami, Tamio , Kakita, Shingo , Chiba, Shigeru , Akinaga, Shiro
IPC分类号： C07D493/20 , C12P17/18 , C12R1/465 , A61K31/365
CPC分类号： C07D493/20 , C12P17/181 , C12R1/465 , Y10S435/886
摘要： The present invention relates to chrolactomycin compound represented by the following formula (I):
or pharmaceutically acceptable salts thereof having antibacterial and antitumor activities.摘要翻译： 本发明涉及由下式（I）表示的己内酰霉素化合物：其具有抗细菌和抗肿瘤活性的
或其药学上可接受的盐。
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