-
公开(公告)号：EP1082439A2
公开(公告)日：2001-03-14
申请号：EP99925954.2
申请日：1999-05-27
摘要： Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
-
12.发明授权A MULTI-PLASMID METHOD FOR PREPARING LARGE LIBRARIES OF POLYKETIDES AND NON-RIBOSOMAL PEPTIDES 有权多质粒用于生产大型图书馆和聚酮化非核糖体肽
公开(公告)号：EP1171583B1
公开(公告)日：2006-06-21
申请号：EP00922192.0
申请日：2000-04-12
发明人： SANTI, Daniel, V. , XUE, Qun , ASHLEY, Gary
摘要： A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.
-
公开(公告)号：EP1320611B1
公开(公告)日：2005-11-09
申请号：EP01973782.4
申请日：2001-04-26
发明人： ARSLANIAN, Robert, L. , ASHLEY, Gary , FRYKMAN, Scott , JULIEN, Bryan , KATZ, Leonard , KHOSLA, Chaitan , LAU, Janice , LICARI, Peter, J. , REGENTIN, Rika , SANTI, Daniel , TANG, Li
IPC分类号： C12N15/52 , C12N15/74 , C12N9/00 , C12N1/21 , C12P17/16 , C12P17/18 , C07D313/00 , C07D413/06 , C07D417/06 , C07D493/04 , C07D493/06
CPC分类号： C12P17/181 , C07D313/00 , C07D405/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/04 , C07D493/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/16 , C12R1/01
摘要： Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
-
公开(公告)号：EP1337540A2
公开(公告)日：2003-08-27
申请号：EP01995209.2
申请日：2001-11-21
发明人： SANTI, Daniel , TIAN, Zong-Qiang , METCALF, Brian , ASHLEY, Gary
IPC分类号： C07H17/08 , A61K31/7048 , A61P1/00
CPC分类号： C07H17/08
摘要： The present invention provides novel macrolide compounds of the formulas for the treatment of gastrointestinal motility disorders.
摘要翻译： 本发明提供了用于治疗胃肠运动障碍的新的大环内酯化合物。
-
15.发明公开BIO-INTERMEDIATES FOR USE IN THE CHEMICAL SYNTHESIS OF POLYKETIDES 审中-公开BIOZWISCHENPRODUKTE FOR USE IN的聚酮的化学合成
公开(公告)号：EP1307579A2
公开(公告)日：2003-05-07
申请号：EP01962062.4
申请日：2001-08-09
IPC分类号： C12P17/06 , C12P17/08 , C12P17/12 , C12P17/16 , C12P17/18 , C12P13/02 , C12P7/26 , C12P11/00 , C07D309/30 , C07D211/76 , C07C275/24
CPC分类号： C07D413/06 , C07D309/30 , C07D309/32 , C07D319/06 , C07D417/06 , C12P7/26 , C12P11/00 , C12P13/02 , C12P17/06 , C12P17/08 , C12P17/12 , C12P17/16 , C12P17/181
摘要： The present invention relates to compounds made by a subset of modules from one or more polyketide synthase ('PKS') genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates ('bio-intermediates') generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specifity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greatly simplified.
-
16.发明公开COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD 失效使用模块化PKS基因簇作为分支构建组合型多肽库
公开(公告)号：EP0979286A2
公开(公告)日：2000-02-16
申请号：EP98918891.7
申请日：1998-04-30
发明人： KHOSLA, Chaitan , ASHLEY, Gary , FU, Hong , KAO, Camilla, M. , MCDANIEL, Robert
IPC分类号： C12N15/52 , C12N15/76 , C12N9/00 , C12N1/21 , C12P17/06 , C07D309/00 , C07D313/04 , C07D493/10 , C07D313/00 , C07H17/04
CPC分类号： C07H17/08 , C07D323/00 , C12N15/52 , C40B40/00
摘要： Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
摘要翻译： 聚酮化合物组合文库可通过适当操作宿主模块化聚酮化合物合酶基因簇，如编码红霉素PKS的基因簇获得。 组合文库可用作药物活性化合物的来源。 另外，使用这种方法制备新颖的聚酮化合物和抗生素。
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.018 秒)
