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19 条记录 (耗时 0.013 秒)

    Process for producing trans-4-hydroxy-l-proline
    11.
    发明公开
    Process for producing trans-4-hydroxy-l-proline 失效
    一种用于制造反式-4-羟基-1-脯氨酸过程。

    公开(公告)号：EP0641862A3

    公开(公告)日：1997-06-04

    申请号：EP94113955.2

    申请日：1994-09-06

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Ozaki, Akio ,  Mori, Hideo ,  Shibasaki, Takeshi ,  Ando, Katsuhiko ,  Chiba, Shigeru

    IPC分类号： C12P13/24 ,  C12N9/02

    CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002

    摘要： Provided is a process for industrially producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium or Amycolatopsis and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. Also provided is a novel enzyme L-proline-4-hydroxylase, which is useful for the process.

    Process for producing cis-3-hydroxy-L-proline
    16.
    发明公开
    Process for producing cis-3-hydroxy-L-proline 失效
    Verfahren zur Herstellung von cis-3-Hydroxy-L-Prolin。

    公开(公告)号：EP0645457A2

    公开(公告)日：1995-03-29

    申请号：EP94113948.7

    申请日：1994-09-06

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Ozaki, Akio ,  Mori, Hideo ,  Shibasaki, Takeshi ,  Ando, Katsuhiko ,  Ochiai, Keiko ,  Chiba, Shigeru ,  Uosaki, Yoichi

    IPC分类号： C12P13/24 ,  C12N9/02

    CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002

    摘要： Provided is a process for industrially producing cis-3-hydroxy-L-proline useful as a raw material for medicines or as an additive to foods. L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is recovered from the aqueous medium. Also provided is a novel enzyme L-proline-3-hydroxylase, which is useful for the process.

    摘要翻译： 提供了用作工业上用作药物原料或作为食品添加剂的顺式-3-羟基-L-脯氨酸的方法。 在衍生自属于链霉菌属或芽孢杆菌属的微生物的酶源的存在下，L-脯氨酸转化为顺式-3-羟基-L-脯氨酸，其催化L-脯氨酸羟基化为顺式-3-羟基-L-脯氨酸， L-脯氨酸，二价铁离子和2-酮戊二酸，在水性介质中回收生成的顺式-3-羟基-L-脯氨酸。 还提供了一种新的L-脯氨酸-3-羟化酶，其可用于该方法。