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公开(公告)号：EP0351865B1
公开(公告)日：1995-05-03
申请号：EP89113431.4
申请日：1989-07-21
发明人： Takahashi, Keiichi , Ichimura, Michio , Katsumata, Shigeo , Ogawa, Tatsuhiro , Morimoto, Makoto , Ashizawa, Tadashi , Kasai, Masaji , Muroi, Kenichi , Saito, Hiromitsu , Sano, Hiroshi , Yasuzawa, Toru
IPC分类号： C07D487/04 , C07D471/04 , A61K31/40 , A61K31/435 , C12P17/18
CPC分类号： C07D471/04 , C07D487/04
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2.发明公开Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same 失效新型VASODILATOR化合物，其制备方法和含有其的药物组合物
公开(公告)号：EP0178902A3
公开(公告)日：1987-10-14
申请号：EP85307411
申请日：1985-10-15
IPC分类号： C12P01/06 , C12N01/20 , A61K35/66 , C12R01/465
摘要： A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing a microorganism of the genus Streptomyces.
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3.发明公开Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same 失效Vasodilatationsverbindungen，它们的制备方法和它们的药物组合物。
公开(公告)号：EP0178902A2
公开(公告)日：1986-04-23
申请号：EP85307411.0
申请日：1985-10-15
摘要： A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing a microorganism of the genus Streptomyces.
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4.发明授权Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same 失效新型VASODILATOR化合物，其制备方法和含有其的药物组合物
公开(公告)号：EP0178902B1
公开(公告)日：1991-01-09
申请号：EP85307411.0
申请日：1985-10-15
摘要： A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing Streptomyces californicus ATCC 3312.
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5.发明公开DC-89 compounds and process for their preparation 失效DC-89-Verbindungen und Verfahren zu ihrer Herstellung。
公开(公告)号：EP0351865A2
公开(公告)日：1990-01-24
申请号：EP89113431.4
申请日：1989-07-21
发明人： Takahashi, Keiichi , Ichimura, Michio , Katsumata, Shigeo , Ogawa, Tatsuhiro , Morimoto, Makoto , Ashizawa, Tadashi , Kasai, Masaji , Muroi, Kenichi , Saito, Hiromitsu , Sano, Hiroshi , Yasuzawa, Toru
IPC分类号： C07D487/04 , C07D471/04 , A61K31/40 , A61K31/435 , C12P17/18
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel DC-89 compounds represented by the general formula:
wherein X represents a single bond or -CH₂-; and when X represents a single bond, Y represents -CH₂Br or -CH₂Cl and when X represents -CH₂-, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.摘要翻译： 由通式表示的新型DC-89化合物：其中X表示单键或-CH 2 - ; 当X表示单键时，Y表示-CH 2 Br或-CH 2 Cl，X表示-CH 2 - ，Y表示Br时，由本发明得到。 该化合物具有抗菌和抗肿瘤活性。
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6.发明公开KS-506 compounds and process for the production thereof 失效KS-506 Verbindungen und Verfahren zu deren Herstellung。
公开(公告)号：EP0335386A1
公开(公告)日：1989-10-04
申请号：EP89105611.1
申请日：1989-03-30
发明人： Kuroda, Kazutoshi , Kase, Hiroshi , Ando, Katsuhiko , Kawamoto, Isao , Yasuzawa, Toru , Sano, Hiroshi , Goto, Joji , Yamada, Koji
IPC分类号： C07C323/22 , C07C327/16 , C07C69/90 , A61K35/74 , C12P1/04 , C12P7/00 , C12P11/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella .
摘要翻译： 通过培养属于被孢霉属属的微生物产生具有抑制环核苷酸磷酸二酯酶的活性的KS-506a，KS-506x和KS-506g以及具有抑制组胺释放活性的KS-506m和KS-506h。
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公开(公告)号：EP0228700B1
公开(公告)日：1989-07-19
申请号：EP86117994.3
申请日：1986-12-23
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Yamashita, Yoshinori , Kawamoto, Isao , Ando, Katsuhiko , Sano, Hiroshi , Yasuzawa, Toru , Shuto, Katsuichi
CPC分类号： C12P33/00 , C07J71/001
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公开(公告)号：EP0228700A1
公开(公告)日：1987-07-15
申请号：EP86117994.3
申请日：1986-12-23
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Yamashita, Yoshinori , Kawamoto, Isao , Ando, Katsuhiko , Sano, Hiroshi , Yasuzawa, Toru , Shuto, Katsuichi
CPC分类号： C12P33/00 , C07J71/001
摘要： Novel substance UCYl003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities:
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公开(公告)号：EP0335386B1
公开(公告)日：1992-09-02
申请号：EP89105611.1
申请日：1989-03-30
发明人： Kuroda, Kazutoshi , Kase, Hiroshi , Ando, Katsuhiko , Kawamoto, Isao , Yasuzawa, Toru , Sano, Hiroshi , Goto, Joji , Yamada, Koji
IPC分类号： C07C323/22 , C07C327/16 , C07C69/90 , A61K35/74 , C12P1/04 , C12P7/00 , C12P11/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
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公开(公告)号：EP0360239A3
公开(公告)日：1990-08-01
申请号：EP89117378.3
申请日：1989-09-20
发明人： Yasuzawa, Toru , Nakanishi, Satoshi , Murakata, Chikara , Kase, Hiroshi , Sano, Hiroshi , Yamada, Koji
IPC分类号： C07H15/203 , C07C69/92 , A61K31/70 , A61K31/235
CPC分类号： C07H15/203
摘要： Disclosed are KS-501 derivatives represented by the formula (I)
wherein X represents a hydrogen atom or COOR₃, Y represents hydroxy or
and R₁, R₂ and R₃ are the same or different and represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, provided that when R₁, R₂ and R₃ are simultaneously hydrogen atoms, and when R₁, R₂ and X are simultaneously hydrogen atoms, Y does not represent
and a pharmaceutically acceptable acid addition salt thereof. The KS-501 derivatives have a platelet aggregation-inhibiting property, and are expected to be useful as antithrombotic agent.
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